Results 1 to 10 of about 25,615 (222)

Insights into Natural Products from Marine-Derived Fungi with Antimycobacterial Properties: Opportunities and Challenges [PDF]

Marine Drugs
Tuberculosis (TB) poses a persistent global health threat exacerbated by the emergence of drug-resistant strains; hence, there is a continuous quest for novel antimicrobial agents.
Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti   +4 more
doaj   +2 more sources

Antimycobacterial Mechanisms and Anti-Virulence Activities of Polyphenolic-Rich South African Medicinal Plants Against Mycobacterium smegmatis [PDF]

Microorganisms
The rise of multidrug-resistant tuberculosis (TB) necessitates alternative therapeutic sources. This study investigated the polyphenolic content and the antioxidant, antimycobacterial, and anti-virulence activities of selected medicinal plants ...
Matsilane L. Mashilo, Mashilo M. Matotoka, Peter Masoko   +2 more
doaj   +2 more sources

Design, synthesis, and in vitro biological evaluation of dehydroaripiprazole derivatives as antituberculosis agents and molecular docking study

Results in Chemistry, 2022
In this study, we describe the synthesis of novel piperazine-substituted 7-(4-chlorobutoxy) quinolin-2(1H) derivatives 5a–z, which were designed through specific structural modifications of aripiprazole.
B. Raja Sekhara Reddy, V. Pratap Reddy Gajulapalli, Estharla Madhu Rekha, Vagolu Siva Krishna, Dharmarajan Sriram, K Sudakar Babu, Eunha Kim   +6 more
doaj   +1 more source

Prospects for Adding Drugs with Known Anti-tuberculosis Activity to the Composition of Bone Cement for Treatment of Tuberculous Arthritis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate the possibility of using linezolid, amikacin, levofloxacin and bedaquiline mixed with bone cement for the treatment of patients with tuberculous arthritis taking into account changes in mechanical properties of bone cement ...
E. O. Peretsmanas, V. S. Zubikov, A. E. Panova, A. N. Gracheva, A. A. Kazyulina, I. A. Gerasimov   +5 more
doaj   +1 more source

Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy-A Case Report from Togo [PDF]

, 2012
Background: In a previous study PCR analysis of clinical samples from suspected cases of Buruli ulcer disease (BUD) from Togo and external quality assurance (EQA) for local microscopy were conducted at an external reference laboratory in Germany.
Abiba Banla Kere, Adolf Diefenhardt, Basil Kobara, Dominik Symank, Ebekalisai Piten, Franz Wiedemann, Gisela Bretzel, Harald Hoffmann, Issaka Maman, Jörg Nitschke, Komi Amekuse, Kossi Badziklou, Marcus Beissner, Moritz Jansson, Richard O. Phillips, Thomas Löscher   +15 more
core   +8 more sources

Antimycobacterial Activity of Rosmarinus officinalis (Rosemary) Extracted by Deep Eutectic Solvents

Separations, 2022
Tuberculosis (TB) is a massive problem for public health and is the leading cause of illness and death worldwide. Rosemary (Rosmarinus officinalis) is used traditionally to treat many diseases, such as infections of the lungs including pulmonary TB.
Ali Sami Dheyab, Mohammed Qahtan Kanaan, Nabeel Abood Hussein, Mohamed Khalid AlOmar, Siti Fatimah Sabran, Mohd Fadzelly Abu Bakar   +5 more
doaj   +1 more source

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity

Biomolecules, 2022
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly required ...
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko   +7 more
doaj   +1 more source

Antimycobacterial Plant Terpenoids [PDF]

Planta Medica, 2001
Abstract. Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. For over thirty years no antitubercular agents with new mechanisms of action have been developed.
C L, Cantrell, S G, Franzblau, N H, Fischer   +2 more
openaire   +2 more sources

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

Molecules, 2020
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year.
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +8 more
doaj   +1 more source

Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

Marine Drugs, 2020
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification ...
Sara García-Davis, Karla Leal-López, Carmen A. Molina-Torres, Lucio Vera-Cabrera, Ana R. Díaz-Marrero, José J. Fernández, Pilar Carranza-Rosales, Ezequiel Viveros-Valdez   +7 more
doaj   +1 more source