Results 11 to 20 of about 25,615 (222)

Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2020
Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero
Melissa D. Chengalroyen, Audrey Jordaan, Ronnett Seldon, Ronnett Seldon, Thomas Ioerger, Scott G. Franzblau, Mohamed Nasr, Digby F. Warner, Digby F. Warner, Valerie Mizrahi, Valerie Mizrahi   +10 more
doaj   +1 more source

In Vitro Potential of the Acetone Leaf Extract and Fractions of Psychotria capensis (Eckl.) Vatke (Rubiaceae) to Combat Co-Infection of Tuberculosis and Helminthiasis

Frontiers in Pharmacology, 2022
Tuberculosis (TB) is a disease of global importance that affects millions of people. Approximately a quarter of the world’s population is currently infected with M.
Abimbola O. Aro, Ibukun M. Famuyide, Ademola A. Oyagbemi, Prudence N. Kabongo-Kayoka, Lyndy J. McGaw   +4 more
doaj   +1 more source

MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]

, 2017
The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin, Meshcheryakov, Vladimir A., Poce, Giovanna, Xu, Zhujun   +3 more
core   +1 more source

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]

, 2009
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu, Beatrice Bechi, Biava, Biava, Biava, Brock, Castagnolo, Daniele Castagnolo, De Logu, Deidda, Fabrizio Manetti, Gutierrez-Lugo, Holzer, Janin, Mafalda Pagano, Manetti, Manuela Saddi, Marco Radi, Maurizio Botta, Rita Meleddu   +19 more
core   +1 more source

In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands

Molecules, 2022
In this study, 10 essential oils (EOs), from nine plants (Cinnamomum camphora, Curcuma longa, Citrus aurantium, Morinda citrifolia, Petroselinum crispum, Plectranthus amboinicus, Pittosporum senacia, Syzygium coriaceum, and Syzygium samarangense) were ...
Bibi Sharmeen Jugreet, Namrita Lall, Isa Anina Lambrechts, Anna-Mari Reid, Jacqueline Maphutha, Marizé Nel, Abdallah H. Hassan, Asaad Khalid, Ashraf N. Abdalla, Bao Le Van, Mohamad Fawzi Mahomoodally   +10 more
doaj   +1 more source

Antibacterial Activity Ods Fractions of Marine Sponge Auletta SP. Against Mycobacterium Smegmatis [PDF]

, 2019
The marine sponge collected from tropical coral reefs in Manado North Sulawesi Indonesia was screened for antimicrobial activities. In the screening program to search for antituberculotic inhibitors, the result found that the ethanol extract ODS ...
Sumilat, D. A. (Deiske)
core   +2 more sources

Vitamin D Status among Pulmonary TB Patients and Non-TB Controls: A Cross-Sectional Study from Mwanza, Tanzania. [PDF]

, 2013
Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections.
Andersen, Ase Bengaard, Changalucha, John, Faurholt-Jepsen, Daniel, Friis, Henrik, Jeremiah, Kidola, Krarup, Henrik, Mølgaard, Christian, Praygod, George, Range, Nyagosya   +8 more
core   +8 more sources

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

Marine Drugs, 2006
: Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic ...
Roberto G. S. Berlinck, Eduardo Hajdu, Célio L. Silva, Fabio C. S. Galetti, Paulo R. R. Minarini, Ana Olívia de Souza, Elissa G. O. Silva, Ana Claudia T. Martins, Gislene G.F. Nascimento, Matthias Köck, Achim Grube, Christoph Timm, Mirna H. R. Seleghim, Jaine H. H. L. de Oliveira   +13 more
doaj   +1 more source