Results 1 to 10 of about 8,551 (160)

C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol [PDF]

Frontiers in Antibiotics, 2023
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin, Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes   +9 more
doaj   +2 more sources

Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis [PDF]

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with drug ...
Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan   +8 more
doaj   +2 more sources

Antimycobacterial Activity of Salicylanilide Benzenesulfonates [PDF]

Molecules, 2012
A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, 1H-NMR and 13C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis ...
Jiřina Stolaříková, Jarmila Vinšová, Martin Krátký, Nabila Guisado Rodriguez   +3 more
doaj   +3 more sources

N-Alkoxyphenylhydroxynaphthalenecarboxamides and Their Antimycobacterial Activity [PDF]

Molecules, 2016
A series of nineteen N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides and a series of their nineteen positional isomers N-(alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides were prepared and characterized.
Tomas Gonec, Sarka Pospisilova, Tereza Kauerova, Jiri Kos, Jana Dohanosova, Michal Oravec, Peter Kollar, Aidan Coffey, Tibor Liptaj, Alois Cizek, Josef Jampilek   +10 more
doaj   +3 more sources

Antimycobacterial and cytotoxicity activity of microcystins [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background The present work aimed to evaluate the antimycobacterial activity and cytotoxicity of Microcystis aeruginosa toxins, the MC-LR variant and purified extract of [D-Leu1] microcystin-LR. Methods The antimicrobial activity of M. aeruginosa extract
Daniela Fernandes Ramos, Alexandre Matthiensen, Wilson Colvara, Ana Paula Souza de Votto, Gilma Santos Trindade, Pedro Eduardo Almeida da Silva, João Sarkis Yunes   +6 more
doaj   +4 more sources

Antimycobacterial activity of the plectasin derivative NZ2114. [PDF]

Front Microbiol
IntroductionMycobacteria have a unique hydrophobic membrane with several lipid-enriched layers that are low in permeability, setting them apart from other bacteria. This complex structure, consisting of three distinct layers is crucial for cell growth, virulence, and providing a barrier to antibiotics. Previously, we identified a plectasin variant, NZX,
Davids C, Rao-Fransson K, Krishnan N, Tenland E, Mörgelin M, Robertson B, Godaly G.   +6 more
europepmc   +4 more sources

Antimycobacterial Activity of Some Turkish Plants

Pharmaceutical Biology, 2004
In this study, 70% ethanol extracts from 98 different plant species distributed among 21 families were evaluated for antimycobacterial activity. Sempervirine was isolated from Buxus sempervirens with a minimum inhibitory concentration (MIC) of 6.25 µg/ml.
Bilge Sener, M Vural, Prasit Palittapongarnpim   +2 more
exaly   +3 more sources

Synthesis and Antimycobacterial Activity of 2,5-Disubstituted and 1,2,5-Trisubstituted Benzimidazoles [PDF]

Frontiers in Chemistry, 2020
The appearance of drug-resistant strains of Mycobacterium tuberculosis and the dramatic increase in infection rates worldwide evidences the urgency of developing new and effective compounds for treating tuberculosis. Benzimidazoles represent one possible
Rogelio Jiménez-Juárez, Wendy Cruz-Chávez, Nayeli de Jesús-Ramírez, Guadalupe Ivonne Castro-Ramírez, Itzel Uribe-González, Gabriela Martínez-Mejía, Ricardo Ruiz-Nicolás, Charmina Aguirre-Alvarado, Charmina Aguirre-Alvarado, Nayeli Shantal Castrejón-Jiménez, Nayeli Shantal Castrejón-Jiménez, Blanca Estela García-Pérez   +11 more
doaj   +2 more sources

Synthesis of Some 2, 6-Disubstituted 4-Amidopyridines and -Thioamidopyridines, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Molecules, 2000
A group of 26 new 2-halogeno-6-alkylsulfanyl- and 2,6-bis-alkylsulfanyl-4-amidopyridines and corresponding thioamidopyridines was synthesised. Some of the amidopyridines and all thioamidopyridines were tested for their antimycobacterial activity against ...
Miroslav Miletin, Jiri Hartl, Z. Odlerova, Martin Dolezal, K. Kralova, Milos Machacek   +5 more
doaj   +3 more sources

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus [PDF]

PeerJ, 2021
Background Infection with Mycobacterium abscessus is usually chronic and is associated with clarithromycin resistance. Increasing drug resistance is a major public-health problem and has led to the search for new antimycobacterial agents.
Auttawit Sirichoat, Irin Kham-ngam, Orawee Kaewprasert, Pimjai Ananta, Awat Wisetsai, Ratsami Lekphrom, Kiatichai Faksri   +6 more
doaj   +2 more sources