Results 1 to 10 of about 19,828 (226)

C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol [PDF]

Frontiers in Antibiotics, 2023
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin, Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes   +9 more
doaj   +2 more sources

Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis [PDF]

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with drug ...
Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan   +8 more
doaj   +2 more sources

Synthesis and Antimycobacterial Activity of 2,5-Disubstituted and 1,2,5-Trisubstituted Benzimidazoles [PDF]

Frontiers in Chemistry, 2020
The appearance of drug-resistant strains of Mycobacterium tuberculosis and the dramatic increase in infection rates worldwide evidences the urgency of developing new and effective compounds for treating tuberculosis. Benzimidazoles represent one possible
Rogelio Jiménez-Juárez, Wendy Cruz-Chávez, Nayeli de Jesús-Ramírez, Guadalupe Ivonne Castro-Ramírez, Itzel Uribe-González, Gabriela Martínez-Mejía, Ricardo Ruiz-Nicolás, Charmina Aguirre-Alvarado, Charmina Aguirre-Alvarado, Nayeli Shantal Castrejón-Jiménez, Nayeli Shantal Castrejón-Jiménez, Blanca Estela García-Pérez   +11 more
doaj   +2 more sources

Synthesis of Some 2, 6-Disubstituted 4-Amidopyridines and -Thioamidopyridines, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

Molecules, 2000
A group of 26 new 2-halogeno-6-alkylsulfanyl- and 2,6-bis-alkylsulfanyl-4-amidopyridines and corresponding thioamidopyridines was synthesised. Some of the amidopyridines and all thioamidopyridines were tested for their antimycobacterial activity against ...
Miroslav Miletin, Jiri Hartl, Z. Odlerova, Martin Dolezal, K. Kralova, Milos Machacek   +5 more
doaj   +3 more sources

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus [PDF]

PeerJ, 2021
Background Infection with Mycobacterium abscessus is usually chronic and is associated with clarithromycin resistance. Increasing drug resistance is a major public-health problem and has led to the search for new antimycobacterial agents.
Auttawit Sirichoat, Irin Kham-ngam, Orawee Kaewprasert, Pimjai Ananta, Awat Wisetsai, Ratsami Lekphrom, Kiatichai Faksri   +6 more
doaj   +2 more sources

Prospects for Adding Drugs with Known Anti-tuberculosis Activity to the Composition of Bone Cement for Treatment of Tuberculous Arthritis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate the possibility of using linezolid, amikacin, levofloxacin and bedaquiline mixed with bone cement for the treatment of patients with tuberculous arthritis taking into account changes in mechanical properties of bone cement ...
E. O. Peretsmanas, V. S. Zubikov, A. E. Panova, A. N. Gracheva, A. A. Kazyulina, I. A. Gerasimov   +5 more
doaj   +1 more source

Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents

Molecules, 2021
The search for novel antimycobacterial drugs is a matter of urgency, since tuberculosis is still one of the top ten causes of death from a single infectious agent, killing more than 1.4 million people worldwide each year.
Negar Maafi, Abdullah Al Mamun, Ondřej Janďourek, Jana Maříková, Kateřina Breiterová, Adéla Diepoltová, Klára Konečná, Anna Hošťálková, Daniela Hulcová, Jiří Kuneš, Eliška Kohelová, Darja Koutová, Marcela Šafratová, Lucie Nováková, Lucie Cahlíková   +14 more
doaj   +1 more source

Potential secondary metabolite from Indonesian Actinobacteria (InaCC A758) against Mycobacterium tuberculosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): This study explored Indonesian Actinobacteria which were isolated from Curcuma zedoaria endophytic microbes and mangrove ecosystem for new antimycobacterial compounds.
Maya Rakhmawatie, Tri Wibawa, Puspita Lisdiyanti, Woro Pratiwi, Ema Damayanti, Mustofa Mustofa   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Thiazolidinone-Containing Quinoxaline-1,4-di-N-oxides as Antimycobacterial and Antifungal Agents

Frontiers in Chemistry, 2020
Tuberculosis and fungal infections can pose serious threats to human health. In order to find novel antimicrobial agents, 26 novel quinoxaline-1,4-di-N-oxides containing a thiazolidinone moiety were designed and synthesized, and their antimycobacterial ...
Heying Zhang, Heying Zhang, Jie Zhang, Jie Zhang, Wei Qu, Shuyu Xie, Lingli Huang, Lingli Huang, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zhenli Liu, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan   +15 more
doaj   +1 more source

Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis

Microbiology Spectrum, 2023
Shorter and more effective treatment regimens as well as new drugs are urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of action, any new ...
Rachel F. Rollo, Giorgia Mori, Timothy A. Hill, Doris Hillemann, Stefan Niemann, Susanne Homolka, David P. Fairlie, Antje Blumenthal   +7 more
doaj   +1 more source