Results 11 to 20 of about 11,373 (215)

Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins [PDF]

ACS Medicinal Chemistry Letters, 2012
Dihydropyridomycins 2 and 3, which lack the characteristic enol ester moiety of the potent antimycobacterial natural product pyridomycin (1), have been prepared from l-Thr, R- and S-hydroxy isovaleric acid, and 3-pyridinecarboxaldehyde. The 2R isomer 2 shows only 4-fold lower anti-Mtb activity than 1, indicating that the enol ester moiety in the ...
Oliver P. Horlacher, Ruben C. Hartkoorn, Stewart T. Cole, Karl-Heinz Altmann   +3 more
openaire   +5 more sources

Antimycobacterial Activity ofTaxus baccata [PDF]

Pharmaceutical Biology, 2003
Crude extracts prepared from various parts of Taxus baccata L. have been evaluated for their antimycobacterial activity. A CHCl3 fraction of the heartwood and ethanol extract of the leaves exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H37Ra strain of 200 µg/ml.
Palittapongarnpim, P, Sener, B, Erdemoglu, N   +2 more
openaire   +4 more sources

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity [PDF]

Molecules, 2000
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid ...
Zbynek Svoboda, Jiri Janota, Milan Slosarek, Zelmira Odlerova, Katarina Kralova, Jiri Kunes, Karel Waisser, Lenka Kubicova   +7 more
doaj   +2 more sources

Prospects for Adding Drugs with Known Anti-tuberculosis Activity to the Composition of Bone Cement for Treatment of Tuberculous Arthritis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate the possibility of using linezolid, amikacin, levofloxacin and bedaquiline mixed with bone cement for the treatment of patients with tuberculous arthritis taking into account changes in mechanical properties of bone cement ...
E. O. Peretsmanas, V. S. Zubikov, A. E. Panova, A. N. Gracheva, A. A. Kazyulina, I. A. Gerasimov   +5 more
doaj   +1 more source

Antimycobacterial activities of riminophenazines [PDF]

Journal of Antimicrobial Chemotherapy, 1999
Riminophenazines were specifically developed as drugs active against Mycobacterium tuberculosis but extensive research over several decades has shown that these compounds are also active against many other mycobacterial infections, particularly those caused by Mycobacterium leprae and the Mycobacterium avium complex (MAC).
V M, Reddy, J F, O'Sullivan, P R, Gangadharam   +2 more
openaire   +2 more sources

Structure activity relationship, acute toxicity and cytotoxicity of antimycobacterial neolignan analogues [PDF]

, 2020
Objectives The study's aims were to evaluate the antimycobacterial activity of 13 synthetic neolignan analogues and to perform structure activity relationship analysis (SAR).
Ferreira, Iasmin, Soares Barata, Lauro Euclides, de Souza, Ana Olivia, Regazi Minarini, Paulo Roberto, Bernabe Alderete, Joel, Melo, Patricia da Silva, Silva, Celio Lopes   +6 more
core   +5 more sources

Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents

Molecules, 2021
The search for novel antimycobacterial drugs is a matter of urgency, since tuberculosis is still one of the top ten causes of death from a single infectious agent, killing more than 1.4 million people worldwide each year.
Negar Maafi, Abdullah Al Mamun, Ondřej Janďourek, Jana Maříková, Kateřina Breiterová, Adéla Diepoltová, Klára Konečná, Anna Hošťálková, Daniela Hulcová, Jiří Kuneš, Eliška Kohelová, Darja Koutová, Marcela Šafratová, Lucie Nováková, Lucie Cahlíková   +14 more
doaj   +1 more source

Potential secondary metabolite from Indonesian Actinobacteria (InaCC A758) against Mycobacterium tuberculosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): This study explored Indonesian Actinobacteria which were isolated from Curcuma zedoaria endophytic microbes and mangrove ecosystem for new antimycobacterial compounds.
Maya Rakhmawatie, Tri Wibawa, Puspita Lisdiyanti, Woro Pratiwi, Ema Damayanti, Mustofa Mustofa   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Thiazolidinone-Containing Quinoxaline-1,4-di-N-oxides as Antimycobacterial and Antifungal Agents

Frontiers in Chemistry, 2020
Tuberculosis and fungal infections can pose serious threats to human health. In order to find novel antimicrobial agents, 26 novel quinoxaline-1,4-di-N-oxides containing a thiazolidinone moiety were designed and synthesized, and their antimycobacterial ...
Heying Zhang, Heying Zhang, Jie Zhang, Jie Zhang, Wei Qu, Shuyu Xie, Lingli Huang, Lingli Huang, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zhenli Liu, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan   +15 more
doaj   +1 more source

Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis

Microbiology Spectrum, 2023
Shorter and more effective treatment regimens as well as new drugs are urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of action, any new ...
Rachel F. Rollo, Giorgia Mori, Timothy A. Hill, Doris Hillemann, Stefan Niemann, Susanne Homolka, David P. Fairlie, Antje Blumenthal   +7 more
doaj   +1 more source