Results 21 to 30 of about 8,621 (178)

Antimycobacterial activity of lichen substances

Phytomedicine, 2010
We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity.
Honda, N. K., Pavan, Fernando Rogério, Coelho, R. G., de Andrade Leite, S. R., Micheletti, A. C., Lopes, T. I. B., Misutsu, M. Y., Beatriz, A., Brum, R. L., Leite, Clarice Queico Fujimura   +9 more
openaire   +3 more sources

Acetone leaf extracts of some South African trees with high activity against Escherichia coli also have good antimycobacterial activity and selectivity index

BMC Complementary and Alternative Medicine, 2017
Background Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities of extracts and isolated compounds
Ishaku L. Elisha, Francien S. Botha, Balungile Madikizela, Lyndy J. McGaw, Jacobus N. Eloff   +4 more
doaj   +1 more source

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp²)-H-Hydroxylation

Pharmaceuticals, 2022
The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s (WHO) goal to end the global TB pandemic by the year 2035.
Alexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, Korana Mudrovcic, Vinayak Singh, Mathew Njoroge, Bjoern B. Burckhardt, Mohanraj Gopalswamy, Beate Lungerich, Lutz Ackermann, Holger Gohlke, Kelly Chibale, Rainer Kalscheuer, Thomas Kurz   +13 more
doaj   +1 more source

Antimycobacterial activity of bacteriocins and their complexes with liposomes [PDF]

Journal of Antimicrobial Chemotherapy, 2007
Bacteriocins (Bcn) are natural peptides that are secreted by several taxonomically distant bacteria and exert bactericidal activity against other bacterial species. Their capacity to inhibit growth of virulent Mycobacterium tuberculosis H37Rv was evaluated in this study.Five different Bcn were isolated and purified from bacterial culture supernatants ...
Vasily, Sosunov, Vladimir, Mischenko, Boris, Eruslanov, Edward, Svetoch, Yulia, Shakina, Norman, Stern, Konstantin, Majorov, Galina, Sorokoumova, Alla, Selishcheva, Alexander, Apt   +9 more
openaire   +2 more sources

Isolation of the Plant Hormone (+)-Abscisic acid as an Antimycobacterial Constituent of the Medicinal Plant Endophyte sp

Natural Product Communications, 2013
An extract of the endophytic fungus Nigropsora sp. (isolate TC2-054) from the Canadian medicinal plant Fragaria virginiana exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
Trevor N. Clark, Katelyn Ellsworth, Haoxin Li, John A. Johnson, Christopher A. Gray   +4 more
doaj   +1 more source

Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with the 4,7-phenanthroline skeleton. Part VI [PDF]

Journal of the Serbian Chemical Society, 2016
A feasible study concerning the synthesis, structure and in vitro antimycobacterial evaluation of new 4,7-phenanthroline derivatives is reported. The preparation is straight and efficient, involving an N-alkylation reaction of 4,7-phenanthroline.
Al Matarneh Cristina M., Ciobanu Catalina I., Mangalagiu Ionel I., Danac Ramona   +3 more
doaj   +1 more source

Nitrobenzoates and Nitrothiobenzoates with Activity against M. tuberculosis

Microorganisms, 2023
Esters of weak acids have shown improved antimycobacterial activity over the corresponding free acids and nitro benzoates in particular have previously shown to have a very intriguing activity. To expand the potential of nitro-derivatives of benzoic acid
João P. Pais, Olha Antoniuk, Raquel Freire, David Pires, Emília Valente, Elsa Anes, Luis Constantino   +6 more
doaj   +1 more source

In Vitro Antimycobacterial Activities of Capuramycin Analogues [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 μg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.
Venkata M, Reddy, Leo, Einck, Carol A, Nacy   +2 more
openaire   +2 more sources

Antimycobacterial activities of novel fluoroquinolones

Biomedicine & Pharmacotherapy, 2009
Fifty-one novel 1-(cyclopropyl/2,4-difluorophenyl/t-butyl)-1,4-dihydro-6-fluoro-7-(sub secondary amino)-4-oxoquinoline-3-carboxylic acids were synthesized and evaluated for their antimycobacterial in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC(
Senthilkumar, Palaniappan, Dinakaran, Murugesan, Yogeeswari, Perumal, china, Arnab, Nagaraja, Valakunja, Sriram, Dharmarajan   +5 more
openaire   +2 more sources

Sulfamethoxazole enhances the antimycobacterial activity of rifampicin [PDF]

Journal of Antimicrobial Chemotherapy, 2012
To investigate the effect of trimethoprim/sulfamethoxazole on the survival of Mycobacterium tuberculosis and trimethoprim and sulfamethoxazole individually and combined with the first-line tuberculosis drugs (isoniazid, rifampicin and ethambutol).M.
Macingwana L, Baker B, Ngwane AH, Harper C, Cotton MF, Hesseling AC, Diacon AH, Van Helden PD, Wiid I   +8 more
openaire   +2 more sources