Results 31 to 40 of about 8,621 (178)

Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Products from an Unidentified Endophyte of the Canadian Medicinal Plant

Natural Product Communications, 2015
An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
Trevor N. Clark, Katelyn T. Ellsworth, Stephanie Jean, Duncan Webster, Gilles A. Robichaud, John A. Johnson, Christopher A. Graya   +6 more
doaj   +1 more source

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Antibiotics, 2020
Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases.
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam   +2 more
doaj   +1 more source

Phytochemical Analysis and Bioactivities of Dombeya rotundifolia and Lippia javanica

Plants
Tuberculosis (TB) remains a major global health challenge, compounded by rising drug resistance. Traditional medicinal plants used for TB-related symptoms represent a valuable yet underexplored source of potential antimycobacterial agents. In this study,
Matsilane L. Mashilo, Mashilo M. Matotoka, Ofentse Mazimba, Peter Masoko   +3 more
doaj   +1 more source

Phytochemical Investigation, Antioxidant and Antimycobacterial Activities of (Lam) Thell Extracts Against

Journal of Evidence-Based Integrative Medicine, 2019
The focus of this study was to evaluate the antioxidants and antimycobacterial activities of extracts of Schkuhria pinnata . Serial exhaustive extraction procedure was employed using solvents of varying polarity to obtain the desired extracts. Thin layer
Peter Masoko PhD, Maano V. Masiphephethu MSc   +1 more
doaj   +1 more source

Novel isoniazid cyclocondensed 1,2,3,4-tetrahydropyrimidine derivatives for treating infectious disease: a synthesis and in vitro biological evaluation

Journal of Acute Disease, 2013
Objective: To synthesize new congeners by incorporating isoniazid with 1,2,3,4-tetrahydropyrimidinones moieties in a single molecular frame work and to evaluate their antimicrobial and antimycobacterial activity.
Karthikeyan Elumalai, Mohammed Ashraf Ali, Manogaran Elumalai, Kalpana Eluri, Sivaneswari Srinivasan   +4 more
doaj   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Therapeutic potential of Zanha africana (Radlk.) Exell: antimycobacterial activity and safety evaluation

Scientific African
Background: Zanha africana (Radlk.) Exell extracts are commonly utilized in Tanzania and other countries for treating conditions associated with HIV and AIDS, including tuberculosis (TB).
Alphonce Ignace Marealle, Michael Qwarse, Ramadhani S.O. Nondo, Alex John Bulashi, Francis Machumi, Alfredi Alfred Moyo, Joseph Sempombe, Paul Malaba, Matthias Heydenreich, Rogers Mwakalukwa, Matobola Joel Mihale, Mainen Julius Moshi   +11 more
doaj   +1 more source

Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India

BMC Complementary and Alternative Medicine, 2017
Background The ethnic population of Arunachal Pradesh uses a number of orchids as such, or in decoction for various ailments. Three untapped orchids namely, Rhynchostylis retusa, Tropidia curculioides and Satyrium nepalense, traditionally used in ...
Manisha Bhatnagar, Nandan Sarkar, Nigam Gandharv, Ona Apang, Sarman Singh, Sabari Ghosal   +5 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide [PDF]

Antimicrobial Agents and Chemotherapy, 1998
ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis , Mycobacterium bovis , and several nontuberculous mycobacteria by a broth dilution method.
M H, Cynamon, R J, Speirs, J T, Welch
openaire   +2 more sources