Results 51 to 60 of about 8,621 (178)

In vitro antimycobacterial activities of pyrazinamide analogs [PDF]

Antimicrobial Agents and Chemotherapy, 1995
We synthesized various pyrazine derivatives and pyrazinamide analogs and assayed their antimycobacterial activities in vitro in order to find new drugs which are more active against Mycobacterium tuberculosis than pyrazinamide and also active against Mycobacterium avium and Mycobacterium intracellulare.
S, Yamamoto, I, Toida, N, Watanabe, T, Ura   +3 more
openaire   +2 more sources

Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacterium smegmatis

International Journal of Mycobacteriology, 2016
Objective/background: According to estimates by the World Health Organization, there were 9.6 million new tuberculosis (TB) cases in 2014: 5.4 million among men, 3.2 million among women, and 1.0 million among children.
Jean Bosco Jouda, Isabelle Kamga Mawabo, Augustin Notedji, Céline Djama Mbazoa, Jean Nkenfou, Jean Wandji, Céline Nguefeu Nkenfou   +6 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Modeling Treatment Response in Tuberculosis Early Bactericidal Activity Trials

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Culture‐based monitoring of bacterial load is slow and susceptible to missing data, contributing to the length and cost of TB clinical trials. Non‐culture‐based alternatives, like the Tuberculosis Molecular Load Bacterial Assay (TB‐MBLA), could represent a solution.
Mairi C. W. McClean, Simon E. Koele, Julia Dreisbach, Susanne Mirold‐Mei, Fred Njeleka, Daniel Mapamba, Bariki Mtafya, Patrick P. J. Phillips, Veronique R. De Jager, Rodney Dawson, Kim Narunsky, Andreas H. Diacon, Elin M. Svensson, Norbert Heinrich, Francesco Paolo Casale, Michael Hoelscher   +15 more
wiley   +1 more source

Antimycobacterial Activity ofTaxus baccata [PDF]

Pharmaceutical Biology, 2003
Crude extracts prepared from various parts of Taxus baccata L. have been evaluated for their antimycobacterial activity. A CHCl3 fraction of the heartwood and ethanol extract of the leaves exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H37Ra strain of 200 µg/ml.
Palittapongarnpim, P, Sener, B, Erdemoglu, N   +2 more
openaire   +2 more sources

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Ocotea notata from Brazilian Restinga

The Scientific World Journal, 2015
The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this genus as O. puberula and O. quixos have been described in the literature, showing antibacterial activity.
Isabela Francisca Borges Costa, Sanderson Dias Calixto, Marlon Heggdorne de Araujo, Tatiana Ungaretti Paleo Konno, Luzineide Wanderley Tinoco, Denise Oliveira Guimarães, Elena B. Lasunskaia, Ivana Ramos Correa Leal, Michelle Frazão Muzitano   +8 more
doaj   +1 more source

Antimycobacterial and anti-inflammatory activities of metabolites from endophytic and soil fungi

Phytomedicine Plus, 2022
Background: Increased prevalence of high virulent strains of Mycobacterium tuberculosis and M. kansasii require the development of new antimycobacterial drugs safe and more effective.
Willian Jonis Andrioli, Thatiana Lopes Bia Ventura Simão, Daniella Passos Ferreira, Marlon Heggdorne Araújo, Sanderson Dias Calixto, Jairo K. Bastos, Lucy Seldin, Elena Lasunskaia, Michelle Frazão Muzitano   +8 more
doaj   +1 more source

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source

Antimycobacterial Activities of Novel Levofloxacin Analogues [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT In order to investigate structure-activity relationships between antimycobacterial activities and basic substituents at the C-10 position of levofloxacin (LVFX), we synthesized a series of pyridobenzoxazine derivatives by replacement of the N -methylpiperazinyl group of LVFX with various basic ...
K, Kawakami, K, Namba, M, Tanaka, N, Matsuhashi, K, Sato, M, Takemura   +5 more
openaire   +2 more sources

Antimycobacterial Mechanisms and Anti-Virulence Activities of Polyphenolic-Rich South African Medicinal Plants Against Mycobacterium smegmatis

Microorganisms
The rise of multidrug-resistant tuberculosis (TB) necessitates alternative therapeutic sources. This study investigated the polyphenolic content and the antioxidant, antimycobacterial, and anti-virulence activities of selected medicinal plants ...
Matsilane L. Mashilo, Mashilo M. Matotoka, Peter Masoko   +2 more
doaj   +1 more source