Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]
, 2018 Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M +8 more
core +3 more sources
BMC Complementary and Alternative Medicine, 2017 Background The ethnic population of Arunachal Pradesh uses a number of orchids as such, or in decoction for various ailments. Three untapped orchids namely, Rhynchostylis retusa, Tropidia curculioides and Satyrium nepalense, traditionally used in ...
Manisha Bhatnagar +5 more
doaj +1 more source
International Journal of Mycobacteriology, 2021 Background: Buruli ulcer (BU) is a neglected tropical disease caused by the Mycobacterium ulcerans. BU is an endemic disease in many communities in sub-Saharan Africa where population have long history of using medicinal plants for treatment.
Isaac Kingsley Amponsah +7 more
doaj +1 more source
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator [PDF]
, 2018 We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Joseph, Ancy +3 more
core +2 more sources
Scientific AfricanBackground: Zanha africana (Radlk.) Exell extracts are commonly utilized in Tanzania and other countries for treating conditions associated with HIV and AIDS, including tuberculosis (TB).
Alphonce Ignace Marealle +11 more
doaj +1 more source
Antituberculosis Activity of Brotowali (Tinospora Crispa) Extract and Fractions Against Mycobacterium Tuberculosis Using Microplate Alamar Blue Assay Method [PDF]
, 2017 Tuberculosis (TB), in which caused by pathogenic bacteria, Mycobacterium tuberculosis, has become the major causes of death among all of infectious diseases.
Irianti, T. (Tatang) +5 more
core
Patent developments in antimycobacterial small-molecule therapeutics [PDF]
, 2005 At. present, clinical management of patients infected with Mycobacterium tuberculosis faces difficult problems, such as the worldwide emergence of multidrug resistant tuberculosis (MDR-TB), and the increase in AIDS-associated infections.
Van Calenbergh, Serge, Van Daele, Ineke
core +2 more sources
Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation
Molecules, 2009 The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides.
Michaela Svobodová +4 more
doaj +1 more source
Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent. [PDF]
PLoS ONE, 2017 Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC50 of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properties ...
Henok Asfaw +7 more
doaj +1 more source
Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities : compounds modified in the imidazole ring [PDF]
, 2010 Purine analogs modified in the five-membered ring have been synthesized and examined for antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro employing the microplate alamar blue assay (MABA). The 9-deaza analogs were only found to be
Charnock, Colin +5 more
core +2 more sources