Results 21 to 30 of about 21,202 (267)

Acetophenones with selective antimycobacterial activity [PDF]

Letters in Applied Microbiology, 2005
Mycobacteria are a serious cause of infections in humans, with limited treatment options, as no new antibiotics have been developed against mycobacteria since the 1960s. In this study, the antimycobacterial activity of a small library of acetophenone (AP) compounds was analysed.Twenty-three AP derivatives were examined for activity against mycobacteria
L, Rajabi, C, Courreges, J, Montoya, R J, Aguilera, T P, Primm   +4 more
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Thiazolidinone-Containing Quinoxaline-1,4-di-N-oxides as Antimycobacterial and Antifungal Agents

Frontiers in Chemistry, 2020
Tuberculosis and fungal infections can pose serious threats to human health. In order to find novel antimicrobial agents, 26 novel quinoxaline-1,4-di-N-oxides containing a thiazolidinone moiety were designed and synthesized, and their antimycobacterial ...
Heying Zhang, Heying Zhang, Jie Zhang, Jie Zhang, Wei Qu, Shuyu Xie, Lingli Huang, Lingli Huang, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zhenli Liu, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan   +15 more
doaj   +1 more source

Antimycobacterial activity of synthetic pamamycins [PDF]

Journal of Antimicrobial Chemotherapy, 2004
Early studies have indicated that pamamycins, a group of macrodiolides first isolated from Streptomyces alboniger, have potent antimicrobial activity against Gram-positive bacteria, fungi and mycobacteria but not against Gram-negative bacteria. The recent availability of highly purified and reasonable quantities of several pamamycins through their ...
Lefèvre, Philippe, Peirs, Priska, Braibant, Martine, Fauville, Maryse, Vanhoof, Raymond, Huygen, Kris, Wang, Xiao-Ming, Pogell, B, Wang, Y, Fischer, P, Metzger, Patricia, Content, Jean   +11 more
openaire   +2 more sources

In-vitro evaluation of the antibacterial activity of the essential oils of Micromeria barbata, Eucalyptus globulus and Juniperus excelsa against strains of Mycobacterium tuberculosis (including MDR), Mycobacterium kansasii and Mycobacterium gordonae

Journal of Infection and Public Health, 2019
Background: Mycobacterium spp. are responsible for several diseases, particularly in immunocompromised populations. The spreading of the resistance to antimycobacterial drugs is a significant problem to the public health and requires to find out a new ...
Khaled El Omari, Monzer Hamze, Saer Alwan, Marwan Osman, Charafeddine Jama, Nour-Eddine Chihib   +5 more
doaj   +1 more source

MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]

, 2017
The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin, Meshcheryakov, Vladimir A., Poce, Giovanna, Xu, Zhujun   +3 more
core   +1 more source

Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases [PDF]

, 2009
Background - There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains ...
Alistair K. Brown, Apoorva Bhatt, Gurdyal S. Besra, Klaus Fütterer, Niyaz Ahmed, Rebecca C. Taylor   +5 more
core   +13 more sources

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

Antimycobacterial Activity of Lichens [PDF]

Pharmaceutical Biology, 2007
Ethanol extracts of nine lichen species, namely Everniastrum cirrhatum (Fr.) Hale ex Sipman (Parmeliaceae), Flavoparmelia caperata (L) Hale (Parmeliaceae), Heterodermia leucomela (L) Poelt (Physciaceae), Lecanora flavidorufa Hue (Lecanoraceae), Leptogium pedicellatum P.M.
Vivek Kumar Gupta, Mahendra P. Darokar, Dharmendra Saikia, Anirban Pal, Atiya Fatima, Suman P.S. Khanuja   +5 more
openaire   +1 more source

Antibacterial Activity Ods Fractions of Marine Sponge Auletta SP. Against Mycobacterium Smegmatis [PDF]

, 2019
The marine sponge collected from tropical coral reefs in Manado North Sulawesi Indonesia was screened for antimicrobial activities. In the screening program to search for antituberculotic inhibitors, the result found that the ethanol extract ODS ...
Sumilat, D. A. (Deiske)
core   +2 more sources

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp²)-H-Hydroxylation

Pharmaceuticals, 2022
The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s (WHO) goal to end the global TB pandemic by the year 2035.
Alexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, Korana Mudrovcic, Vinayak Singh, Mathew Njoroge, Bjoern B. Burckhardt, Mohanraj Gopalswamy, Beate Lungerich, Lutz Ackermann, Holger Gohlke, Kelly Chibale, Rainer Kalscheuer, Thomas Kurz   +13 more
doaj   +1 more source