Results 31 to 40 of about 21,202 (267)

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]

, 2009
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu, Beatrice Bechi, Biava, Biava, Biava, Brock, Castagnolo, Daniele Castagnolo, De Logu, Deidda, Fabrizio Manetti, Gutierrez-Lugo, Holzer, Janin, Mafalda Pagano, Manetti, Manuela Saddi, Marco Radi, Maurizio Botta, Rita Meleddu   +19 more
core   +1 more source

In vitro antimycobacterial and cytotoxic data on medicinal plants used to treat tuberculosis

Data in Brief, 2016
This article contains data on in vitro antimycobacterial activity and cytotoxicity of hydroethanolic crude extracts from five selected medicinal plant species traditionally used to treat tuberculosis in Ghanaian ethnomedicine, see “Medicinal plants used ...
Joseph M. Nguta, Regina Appiah-Opong, Alexander K. Nyarko, Dorothy Yeboah-Manu, Phyllis G.A. Addo, Isaac D. Otchere, Abena Kissi-Twum   +6 more
doaj   +1 more source

Design, synthesis and antimycobacterial evaluation of some new azaheterocycles with the 4,7-phenanthroline skeleton. Part VI [PDF]

Journal of the Serbian Chemical Society, 2016
A feasible study concerning the synthesis, structure and in vitro antimycobacterial evaluation of new 4,7-phenanthroline derivatives is reported. The preparation is straight and efficient, involving an N-alkylation reaction of 4,7-phenanthroline.
Al Matarneh Cristina M., Ciobanu Catalina I., Mangalagiu Ionel I., Danac Ramona   +3 more
doaj   +1 more source

Nitrobenzoates and Nitrothiobenzoates with Activity against M. tuberculosis

Microorganisms, 2023
Esters of weak acids have shown improved antimycobacterial activity over the corresponding free acids and nitro benzoates in particular have previously shown to have a very intriguing activity. To expand the potential of nitro-derivatives of benzoic acid
João P. Pais, Olha Antoniuk, Raquel Freire, David Pires, Emília Valente, Elsa Anes, Luis Constantino   +6 more
doaj   +1 more source

Acetone leaf extracts of some South African trees with high activity against Escherichia coli also have good antimycobacterial activity and selectivity index

BMC Complementary and Alternative Medicine, 2017
Background Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities of extracts and isolated compounds
Ishaku L. Elisha, Francien S. Botha, Balungile Madikizela, Lyndy J. McGaw, Jacobus N. Eloff   +4 more
doaj   +1 more source

In vitro and intracellular antimycobacterial activity of a Bacillus pumilus strain [PDF]

, 2012
Despite the declaration of tuberculosis (TB) as a global emergency by the world health organization (WHO) about 20 years ago, the worldwide problem of this disease has worsened due to increased drug resistance of tuberculosis bacilli and acquired ...
David, Suzanna, El Guendouzi, Souraya, El Ouarti, Asmae, Haggoud, Abdellatif, Hassi, Mohammed, Ibn Souda, Saad, Iraqui, Mohammed   +6 more
core   +1 more source

Antimycobacterial activity of lichen substances

Phytomedicine, 2010
We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity.
Honda, N. K., Pavan, Fernando Rogério, Coelho, R. G., de Andrade Leite, S. R., Micheletti, A. C., Lopes, T. I. B., Misutsu, M. Y., Beatriz, A., Brum, R. L., Leite, Clarice Queico Fujimura   +9 more
openaire   +3 more sources

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Antibiotics, 2020
Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases.
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam   +2 more
doaj   +1 more source

Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea [PDF]

, 2016
Tuberculosis is a major threat for mankind and the emergence of resistance strain of Mycobacterium tuberculosis (Mtb) against first line antibiotics makes it lethal for human civilization.
Charan Raja, Mamilla R., Datta, Dhrubajyoti, Debnath, Joy, Franzblau, Scott G., Gramajo, Hugo Cesar, Halloum, Iman, Kar Mahapatra, Santanu, Kremer, Laurent, Tsai, Yi Ting, Velappan, Anand Babu, Wan, Baojie   +10 more
core   +1 more source

Isolation and identification of Bacillus strains with antimycobacterial activity [PDF]

, 2011
Tuberculosis is the principal cause of death worldwide due to an infectious disease. The resurgence of tuberculosis, followed by the increase in prevalence of infections caused by nontuberculous mycobacteria (NTM), as well as the multi-drug resistance ...
Abdellah, Houari, Abdellatif, Haggoud, David, Susana, El Guendouzi, Souraya, Mohammed, Hassi, Mohammed, Iraqui, Saad Ibn, Souda   +6 more
core   +1 more source