Results 41 to 50 of about 21,202 (267)

Type I interferons in tuberculosis: Foe and occasionally friend [PDF]

, 2018
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K, Moreira-Teixeira, L, O'Garra, A, Sher, A   +3 more
core   +1 more source

Antimycobacterial activities of novel fluoroquinolones

Biomedicine & Pharmacotherapy, 2009
Fifty-one novel 1-(cyclopropyl/2,4-difluorophenyl/t-butyl)-1,4-dihydro-6-fluoro-7-(sub secondary amino)-4-oxoquinoline-3-carboxylic acids were synthesized and evaluated for their antimycobacterial in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC(
Senthilkumar, Palaniappan, Dinakaran, Murugesan, Yogeeswari, Perumal, china, Arnab, Nagaraja, Valakunja, Sriram, Dharmarajan   +5 more
openaire   +2 more sources

Antimycobacterial Activity ofTaxus baccata [PDF]

Pharmaceutical Biology, 2003
Crude extracts prepared from various parts of Taxus baccata L. have been evaluated for their antimycobacterial activity. A CHCl3 fraction of the heartwood and ethanol extract of the leaves exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H37Ra strain of 200 µg/ml.
Palittapongarnpim, P, Sener, B, Erdemoglu, N   +2 more
openaire   +2 more sources

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis [PDF]

, 2008
As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as ...
Ahmad, Alessandro De Logu, Beatrice Bechi, Bieringer, Brooks, Burman, Daniele Castagnolo, De Logu, Espinal, Fabrizio Manetti, Frieden, Holzer, Holzer, Janin, Jensen, Kutterer, Lorenza Chisu, Manetti, Manetti, Marco Radi, Matteo Magnani, Maurizio Botta, O’Brien, Rita Meleddu, Sibilla Supino, Smellie, Smellie, Smellie   +27 more
core   +1 more source

In vitro Anti-Mycobacterium ulcerans and cytotoxic activities of some selected medicinal plants and an indoloquinoline alkaloid

International Journal of Mycobacteriology, 2021
Background: Buruli ulcer (BU) is a neglected tropical disease caused by the Mycobacterium ulcerans. BU is an endemic disease in many communities in sub-Saharan Africa where population have long history of using medicinal plants for treatment.
Isaac Kingsley Amponsah, Philip Kobla Atchoglo, Raphael Yaw Ackah, Patrick Valere Tsouh Fokou, Samuel Yaw Aboagye, Dorothy Yeboah-Manu, Regina Appiah-Opong, Abraham Yeboah Mensah   +7 more
doaj   +1 more source

Antimycobacterial activity of 2-methyl-adenosine [PDF]

Journal of Antimicrobial Chemotherapy, 2003
The aims of this study were to assess the in vitro activity of 2-methyl-adenosine against Mycobacterium tuberculosis and evaluate, and to intracellular efficacy, and to evaluate its effectiveness against M. tuberculosis in a persistent state model and examine its potential mechanism of action.In vitro activity was determined by means of a colorimetric ...
Esther W, Barrow, Louise, Westbrook, Namita, Bansal, William J, Suling, Joseph A, Maddry, William B, Parker, William W, Barrow   +6 more
openaire   +2 more sources

Phytochemical Investigation, Antioxidant and Antimycobacterial Activities of (Lam) Thell Extracts Against

Journal of Evidence-Based Integrative Medicine, 2019
The focus of this study was to evaluate the antioxidants and antimycobacterial activities of extracts of Schkuhria pinnata . Serial exhaustive extraction procedure was employed using solvents of varying polarity to obtain the desired extracts. Thin layer
Peter Masoko PhD, Maano V. Masiphephethu MSc   +1 more
doaj   +1 more source

Novel isoniazid cyclocondensed 1,2,3,4-tetrahydropyrimidine derivatives for treating infectious disease: a synthesis and in vitro biological evaluation

Journal of Acute Disease, 2013
Objective: To synthesize new congeners by incorporating isoniazid with 1,2,3,4-tetrahydropyrimidinones moieties in a single molecular frame work and to evaluate their antimicrobial and antimycobacterial activity.
Karthikeyan Elumalai, Mohammed Ashraf Ali, Manogaran Elumalai, Kalpana Eluri, Sivaneswari Srinivasan   +4 more
doaj   +1 more source

Antimycobacterial and cytotoxicity activities of free and liposome-encapsulated 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine [PDF]

, 2010
The antimycobacterial activity of 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine (BBAP), free or incorporated in preformed liposomes, on extracellular M.
ANDRADE-SANTANA, Maria H., DURÁN, Nelson, SILVA, Célio L., SOUZA, Ana O. de   +3 more
core   +2 more sources

Evaluation of antimycobacterial, leishmanicidal and antibacterial activity of three medicinal orchids of Arunachal Pradesh, India

BMC Complementary and Alternative Medicine, 2017
Background The ethnic population of Arunachal Pradesh uses a number of orchids as such, or in decoction for various ailments. Three untapped orchids namely, Rhynchostylis retusa, Tropidia curculioides and Satyrium nepalense, traditionally used in ...
Manisha Bhatnagar, Nandan Sarkar, Nigam Gandharv, Ona Apang, Sarman Singh, Sabari Ghosal   +5 more
doaj   +1 more source