Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities : compounds modified in the imidazole ring [PDF]
, 2010 Purine analogs modified in the five-membered ring have been synthesized and examined for antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro employing the microplate alamar blue assay (MABA). The 9-deaza analogs were only found to be
Charnock, Colin +5 more
core +2 more sources
Antimycobacterial Activities of Novel Levofloxacin Analogues [PDF]
Antimicrobial Agents and Chemotherapy, 2000 ABSTRACT In order to investigate structure-activity relationships between antimycobacterial activities and basic substituents at the C-10 position of levofloxacin (LVFX), we synthesized a series of pyridobenzoxazine derivatives by replacement of the N -methylpiperazinyl group of LVFX with various basic ...
K, Kawakami +5 more
openaire +2 more sources
Non-disulfide-Bridge peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits the growth of mycobacterium abscessus subsp. massiliense [PDF]
, 2017 Multi-drug resistant microorganisms have been a growing concern during the last decades due to their contribution in mortality rates worldwide. Antimicrobial peptides (AMPs) are broad spectrum antimicrobial agents that display potent microbicidal ...
Kipnis, Ana Paula Junqueira +8 more
core +1 more source
Synthesis and Antimycobacterial Activity of 2,1′-Dihydropyridomycins [PDF]
ACS Medicinal Chemistry Letters, 2012 Dihydropyridomycins 2 and 3, which lack the characteristic enol ester moiety of the potent antimycobacterial natural product pyridomycin (1), have been prepared from l-Thr, R- and S-hydroxy isovaleric acid, and 3-pyridinecarboxaldehyde. The 2R isomer 2 shows only 4-fold lower anti-Mtb activity than 1, indicating that the enol ester moiety in the ...
Oliver P. Horlacher +3 more
openaire +2 more sources
Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent. [PDF]
PLoS ONE, 2017 Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC50 of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properties ...
Henok Asfaw +7 more
doaj +1 more source
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]
, 2018 Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M +8 more
core +3 more sources
Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation
Molecules, 2009 The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides.
Michaela Svobodová +4 more
doaj +1 more source
Antimycobacterial and anti-inflammatory activities of metabolites from endophytic and soil fungi
Phytomedicine Plus, 2022 Background: Increased prevalence of high virulent strains of Mycobacterium tuberculosis and M. kansasii require the development of new antimycobacterial drugs safe and more effective.
Willian Jonis Andrioli +8 more
doaj +1 more source
Esters of pyrazinoic acid are active against pyrazinamide-resistant strains of Mycobacterium tuberculosis and other naturally resistant mycobacteria in vitro and ex vivo within macrophages. [PDF]
, 2015 Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in
Carmo, N +6 more
core +1 more source
Scientific AfricanBackground: Zanha africana (Radlk.) Exell extracts are commonly utilized in Tanzania and other countries for treating conditions associated with HIV and AIDS, including tuberculosis (TB).
Alphonce Ignace Marealle +11 more
doaj +1 more source