Results 71 to 80 of about 21,202 (267)

Sulfamethoxazole enhances the antimycobacterial activity of rifampicin [PDF]

Journal of Antimicrobial Chemotherapy, 2012
To investigate the effect of trimethoprim/sulfamethoxazole on the survival of Mycobacterium tuberculosis and trimethoprim and sulfamethoxazole individually and combined with the first-line tuberculosis drugs (isoniazid, rifampicin and ethambutol).M.
Macingwana L, Baker B, Ngwane AH, Harper C, Cotton MF, Hesseling AC, Diacon AH, Van Helden PD, Wiid I   +8 more
openaire   +2 more sources

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, EarlyView.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. [PDF]

PLoS ONE, 2012
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Isaac M Westwood, Sanjib Bhakta, Alun Christopher Garner, David L Wilson, Peter T Seden, Stephen G Davies, Angela J Russell, Elspeth F Garman, Edith Sim   +13 more
doaj   +1 more source

Targeting Staphylococcus aureus Biofilms Through Aurisin Derivatives From Neonothopanus nambi of African Origin

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study describes the isolation and characterization of potent bioactive compounds from the fungal strain Neonothopanus nambi, followed by structural elucidation. The compounds shown are dimeric aristolane‐type sesquiterpenoids, identified as aurisins D (1) and B (2).
Syeda J. Khalid, Njogu M. Kimani, Yuanyuyue Huang, Mathias Müsken, Jan‐Peer Wennrich, Jonas Bentrup, Miroslav Kolařík, Josphat Clemet Matasyoh, Hedda Schrey   +8 more
wiley   +1 more source

Antimycobacterial Mechanisms and Anti-Virulence Activities of Polyphenolic-Rich South African Medicinal Plants Against Mycobacterium smegmatis

Microorganisms
The rise of multidrug-resistant tuberculosis (TB) necessitates alternative therapeutic sources. This study investigated the polyphenolic content and the antioxidant, antimycobacterial, and anti-virulence activities of selected medicinal plants ...
Matsilane L. Mashilo, Mashilo M. Matotoka, Peter Masoko   +2 more
doaj   +1 more source

Antimicrobial effects of folk medicinal plants from the North of Iran against Mycobacterium tuberculosis [PDF]

, 2015
Background: Medicinal plants have been used traditionally in Golestan province (north of Iran), against Mycobacterium tuberculosis or the clinical signs of tuberculosis (TB).
Davoodi, H., Ghaemi, E.A., Ghazisaidi, K., Jahanpour, N., Jahanpour, S., Mazandarani, M., Samet, M.   +6 more
core  

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide [PDF]

Antimicrobial Agents and Chemotherapy, 1998
ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis , Mycobacterium bovis , and several nontuberculous mycobacteria by a broth dilution method.
M H, Cynamon, R J, Speirs, J T, Welch
openaire   +2 more sources

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Catalytic Strategies For the Synthesis of Dehydrozingerone: Structural Features and Emerging Applications—A Critical Review

ChemCatChem, Volume 18, Issue 1, 15 January 2026.
This review emphasizes the main methods for synthesizing dehydrozingerone (DHZ), highlighting the aldol condensation reaction of vanillin with acetone using homogeneous and heterogeneous catalysts. Furthermore, the main pharmacological properties that characterize DHZ are presented, along with current challenges and perspectives in its production ...
Paula Ramirez, José J. Martinez, Gustavo Romanelli, Maria H. Brijaldo, Fabio B. Passos   +4 more
wiley   +1 more source

Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity [PDF]

, 2017
A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared.
Abrahams, Aeluri, Ballell, Batt, Beckmann, Cherney, Collins, Comer, Comer, Connors, Corte, Cox, Dinsmore, Driggers, Ertl, Franzblau, Giordanetto, Grossmann, Hong, Irwin, Kitsiou, Kopp, Kuhn, Lennard, Lipkus, Marcaurelle, Morton, Nie, Over, Pye, Stanton, Tao, Taylor   +32 more
core   +2 more sources