Results 71 to 80 of about 5,494 (181)

Design, Synthesis and Antiplasmodial Activities of a Library of Fluorine-Based 3-Benzylmenadiones

Molecules
Plasmodione is a potent early antiplasmodial compound. A metabolic study on mice treated with plasmodione revealed that 6-hydroxy–plasmodione was the main metabolite eliminated in the urine of treated mice. To block the metabolic pathway in the host, the
Matthieu Roignant, Jimmy Richard, Maxime Donzel, Matthias Rottmann, Pascal Mäser, Elisabeth Davioud-Charvet   +5 more
doaj   +1 more source

Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies

Molecules
Ψ-1,4-naphthoquinones (Ψ-NQ) are non-quinoid compounds in which aromaticity—found in 1,4-naphthoquinones—is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs of 1,4-naphthoquinones in an oxidative
Elena Cesar-Rodo, Baptiste Dupouy, Cécile Häberli, Jean-Marc Strub, David L. Williams, Pascal Mäser, Matthias Rottmann, Jennifer Keiser, Don Antoine Lanfranchi, Elisabeth Davioud-Charvet   +9 more
doaj   +1 more source

A REVIEW ON THE CHEMISTRY AND PHARMACOLOGY OF Rennellia elliptica Korth

Indonesian Journal of Tropical and Infectious Disease, 2017
Rennellia elliptica, popularly dubbed as Malaysian Ginseng, is widely used in traditional medicine among the local Jakun community in Endau-Rompin State Park, Pahang, Malaysia. The decoction of the roots is traditionally taken for treatment of body aches,
Che Puteh Osman, Nor Hadiani Ismail
doaj   +1 more source

In vitro antiplasmodial activity and toxicity assessment of plant extracts used in traditional malaria therapy in the Lake Victoria Region

Memorias do Instituto Oswaldo Cruz, 2009
As part of our program screening the flora of the Lake Victoria Region, a total of 54 organic extracts from seven plant families (8 species) were individually tested for antiplasmodial activity against chloroquine-sensitive [Sierra Leone (D-6)] and ...
Teresa Akeng'a Ayuko, Richard Njihia Njau, Wanjala Cornelius, Nyangasi Leah, Isiah Omollo Ndiege   +4 more
doaj   +1 more source

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Marine Drugs, 2015
Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently ...
Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis   +5 more
doaj   +1 more source

Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives

Molecules, 2008
The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.
Antonio Monge, Livia Vivas, Ignacio Aldana, Silvia Pérez-Silanes, Saioa Ancizu, Beatriz Solano, Asunción Burguete, Raquel Villar, Emily Bongard, Sarah Charnaud, Esther Vicente   +10 more
doaj   +1 more source

Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata

Molecules, 2017
In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL ...
Yoseph Atilaw, Sandra Duffy, Matthias Heydenreich, Lois Muiva-Mutisya, Vicky M. Avery, Máté Erdélyi, Abiy Yenesew   +6 more
doaj   +1 more source

Phytochemical, Antimicrobial and Antiprotozoal Evaluation of Garcinia Mangostana Pericarp and α-Mangostin, Its Major Xanthone Derivative

Molecules, 2013
Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of ...
Louis Maes, Mahmoud H. Assaf, KamalEldin H. El Tahir, Mohamed Farag, Adnan J. Al-Rehaily, Omer A. Basudan, Ramzi A. Mothana, Nawal M. Al-Musayeib, Shaza M. Al-Massarani, Ali A. El Gamal   +9 more
doaj   +1 more source

Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

International Journal for Parasitology: Drugs and Drug Resistance
Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is hampered by insecticide and antimalarial drug resistance. Consequently, the need to discover new antimalarial lead compounds remains urgent.
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Larnelle F. Garnie, Deyun Qiu, Timothy J. Egan, Adele M. Lehane, Yvette Jackson, Kevin J. Saliba, Nadale Downer-Riley   +11 more
openaire   +3 more sources

In vivo antiplasmodial activity evaluation of the leaves of Balanites rotundifolia (Van Tiegh.) Blatter (Balanitaceae) against Plasmodium berghei

Journal of Experimental Pharmacology, 2017
Seyfe Asrade,1 Yohannes Mengesha,2 Getachew Moges,2 Dessalegn Asmelashe Gelayee1 1Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, 2Department of Pharmaceutics and Social Pharmacy ...
Asrade S, Mengesha Y, Moges G, Gelayee DA   +3 more
doaj