Results 61 to 70 of about 5,494 (181)

Antigonococcal Activity and Cytotoxicity Screening of Three Ziziphus Species Indigenous to South Africa

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Ziziphus species in South Africa are widely used to treat gonorrhea; however, to this day, there has been no scientific validation of their ethnomedicinal use. This study tentatively identified phytol, betulin, and hexadecanoic acid to be linked to the observed antigonococcal activity.
Mcebisi J. Mabuza, Marcel Kaiser, Thilivhali E. Tshikalange, Abdullahi A. Yusuf, Mahwahwatse J. Bapela   +4 more
wiley   +1 more source

Discovery of Potent Antimalarial Agents Targeting Plasmodium falciparum DNA Gyrase B by Integrating Computational and Experimental Approaches

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
An integrated computational and experimental drug‐discovery approach identified UNC8153 as a potential novel scaffold active against drug‐sensitive and artemisinin‐resistant P. falciparum strains through inhibition of apicoplast PfGyrB. ABSTRACT The global spread of drug‐resistant Plasmodium falciparum, particularly artemisinin‐resistant strains ...
Biswajit Naik, Welka Sahu, Guneswar Sethi, Cherish Prashar, Gajendra Mohan Baldodiya, Jyoti Poswal, Chandi C. Mandal, Jeong Ho Hwang, Kailash C. Panday, K. Sony Reddy, Dhaneswar Prusty   +10 more
wiley   +1 more source

Constituents of the Roots and Leaves of Ekebergia capensis and Their Potential Antiplasmodial and Cytotoxic Activities

Molecules, 2014
A new triterpenoid, 3-oxo-12β-hydroxy-oleanan-28,13β-olide (1), and six known triterpenoids 2–7 were isolated from the root bark of Ekebergia capensis, an African medicinal plant. A limonoid 8 and two glycoflavonoids 9–10 were found in its leaves.
Beatrice N. Irungu, Jennifer A. Orwa, Amra Gruhonjic, Paul A. Fitzpatrick, Göran Landberg, Francis Kimani, Jacob Midiwo, Máté Erdélyi, Abiy Yenesew   +8 more
doaj   +1 more source

Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

Molecules, 2020
Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a Malaysian Moorea bouillonii and a Red ...
Imam Fathoni, Julie G. Petitbois, Walied M. Alarif, Ahmed Abdel-Lateff, Sultan S. Al-Lihaibi, Erina Yoshimura, Yasuyuki Nogata, Charles S. Vairappan, Eti Nurwening Sholikhah, Tatsufumi Okino   +9 more
doaj   +1 more source

Total Synthesis and Antimalarial Studies of Caelestines A–C

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith, Aaron M. Lock, Vicky M. Avery, Rohan A. Davis   +3 more
wiley   +1 more source

Comparative Phytochemical Analysis of Five South African Bulbine Species Using Chromatography‐Based Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Comprehensive chromatographic and chemometric profiling of five medicinal South African Bulbine species across leaves, rhizomes, and roots reveals 73 metabolites, including species‐specific phenylanthraquinones, flavonoids, and anthocyanins, that serve as reliable chemical markers for species authentication.
Ramoagi T. Segone, Maxleene Sandasi, Efficient Ncube, Weiyang Chen, Bharathi Avula, Kumar Katragunta, Ikhlas A. Khan, Alvaro M. Viljoen   +7 more
wiley   +1 more source

Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products

Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.
An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman, Mathieu Frenette, Sylvain Canesi   +2 more
wiley   +1 more source

Exploring Passive Permeability Profiles of Cyclic Heptapeptide Chemical Space Uncovers Bioactivity of Mortiamide Scaffold Driven by Colloidal Aggregation

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
A comprehensive stereochemical and physicochemical survey of cyclic heptapeptide chemical space reveals that the mortiamide natural product scaffold possesses intrinsically low aqueous solubility and forms amyloid‐like fibril aggregates. Multiple orthogonal assays demonstrate that the observed cytotoxicity arises from colloidal aggregation rather than ...
Jaru Taechalertpaisarn, Alexander Engstrom, Maria Sajimon, Beverley M. Rabbitts, Vitor H. Balasco Serrão, Satoshi Ono, Jevgenij A. Raskatov, Timothy C. Johnstone, R. Scott Lokey   +8 more
wiley   +1 more source

In Vitro, In Silico, and In Vivo Evaluation of Antiplasmodial Activity of Ursodeoxycholic Acid Following GNPS Dereplication of an Active Streptomyces sp. Fraction

Pharmaceuticals
Background/Objectives: The emergence of drug-resistant Plasmodium falciparum highlights the need for new antiplasmodial compounds with distinct mechanisms of action.
Nanang R. Ariefta, Baldorj Pagmadulam, Takako Aboshi, Yoshifumi Nishikawa   +3 more
doaj   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source