Results 41 to 50 of about 5,494 (181)

Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy

Journal of Tropical Medicine, 2015
Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations ...
Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu   +2 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Antimalarial activity and toxicity of Garcinia mangostana L. pericarp extracts and major xanthones: A systematic review of in vitro and in vivo studies [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Malaria morbidity remains high, and resistance to antimalarial drugs and diagnostics continues to expand. Aims: To systematically evaluate the in vitro/in vivo antimalarial efficacy and toxicity of Garcinia mangostana L. pericarp extracts (MP)
Joanne T. Winata, Ahmad K. Nugroho, Yosi B. Murti, Arief Nurrochmad   +3 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]Pyridine [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT A series of [(aryl)arylsufanylmethyl]pyridines (AASMP) have been synthesized. These compounds inhibited hemozoin formation, formed complexes ( K D = 12 to 20 μM) with free heme (ferriprotoporphyrin IX) at a pH close to the pH of the parasite food vacuole ...
Sanjay, Kumar, Sajal Kumar, Das, Sumanta, Dey, Pallab, Maity, Mithu, Guha, Vinay, Choubey, Gautam, Panda, Uday, Bandyopadhyay   +7 more
openaire   +2 more sources

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Chemical Composition and In Vitro Antiplasmodial Activity of the Ethanolic Extract of Cyperus articulatus var. nodosus Residue

Pathogens, 2020
Cyperus articulatus L. is popularly known as priprioca. Its rhizomes are used as a medicine in the treatment of malaria in traditional medicine. Since priprioca oil is extracted for commercial purpose, we evaluated if the components from the priprioca ...
Francisco Flávio Vieira de Assis, Nazaré Carneiro da Silva, Waldiney Pires Moraes, Lauro Euclides Soares Barata, Antonio Humberto Hamad Minervino   +4 more
doaj   +1 more source

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Antibiotics, 2023
In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in
Oluwatofunmilayo A. Diyaolu, Gagan Preet, Adeshola A. Fagbemi, Frederick Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Olusoji O. Adebisi, Emmanuel T. Oluwabusola, Bruce F. Milne, Marcel Jaspars, Rainer Ebel   +10 more
doaj   +1 more source

High‐Resolution LC–MS/MS Characterization of Budmunchiamine‐Type Alkaloids in Albizia niopoides

Rapid Communications in Mass Spectrometry, Volume 40, Issue 19, 15 October 2026.
ABSTRACT Rationale Budmunchiamines are macrocyclic spermine alkaloids that constitute a distinctive class of polyamine natural products predominantly found in species of the genus Albizia. Comprehensive characterization of these compounds remains challenging because of their structural diversity and the limited availability of reference standards. This
Maria L. A. Majevski, Lienne D'Auria Lima, Adriana C. C. Reis, Leonan I. C. R. Santos, Brenno F. S. Vargas, Markus Kohlhoff, Geraldo Célio Brandão   +6 more
wiley   +1 more source