Results 31 to 40 of about 5,494 (181)

Antiplasmodial Activity of Lauryl-Lysine Oligomers [PDF]

Antimicrobial Agents and Chemotherapy, 2007
ABSTRACT The ever evolving resistance of the most virulent malaria parasite, Plasmodium falciparum , to antimalarials necessitates the continuous development of new drugs. Our previous analysis of the antimalarial activities of the hemolytic antimicrobial peptides dermaseptins and their acylated ...
I, Radzishevsky, M, Krugliak, H, Ginsburg, A, Mor   +3 more
openaire   +2 more sources

Medicinal Plants with Antimalarial Potentials from Northern Nigeria: A Review [PDF]

Trends in Pharmaceutical Sciences
Malaria is a prevalent infectious disease that is transmitted by parasites through the bite of infected mosquitoes. Despite advancements in medical science, malaria is still a significant global health challenge, especially in regions like northern ...
SULEIMAN JADA, Yusuf Umar, Mohammed Maikudi Usman, Abdullahi Usman Wurochekke   +3 more
doaj   +1 more source

Ex vivo and In vitro antiplasmodial activities of approved drugs predicted to have antimalarial activities using chemogenomics and drug repositioning approach

Heliyon, 2023
High malaria mortality coupled with increased emergence of resistant multi-drug resistant strains of Plasmodium parasite, warrants the development of new and effective antimalarial drugs.
Douglas O. Ochora, Reagan M. Mogire, Rael J. Masai, Redemptah A. Yeda, Edwin W. Mwakio, Joseph G. Amwoma, Dancan M. Wakoli, Abiy Yenesew, Hoseah M. Akala   +8 more
doaj   +1 more source

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

BMC Complementary and Alternative Medicine, 2017
Background In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of
Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla, Jaya Parkash Yadav   +4 more
doaj   +1 more source

Suppressive and curative antiplasmodial properties of Nauclea latifolia root extract and fractions against erythrocytic stage of mice-infective chloroquine-sensitive Plasmodium berghei NK-65

Journal of Medicinal Plants for Economic Development, 2020
Background: Malaria remains a devastating disease, particularly in the tropics, where it is the highest killer of pregnant women and children under the age of 5 years.
Chinwe S. Alaribe, Akolade R. Oladipupo, Miracle O. Nani, Innocent N. Ijeoma, Bolutiwi D. Olanipekun, Herbert A.B. Coker   +5 more
doaj   +1 more source

Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides. [PDF]

Angew Chem Int Ed Engl
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Candra H, Wang XJ, Go KD, Feng L, Cai M, Ma GL, Widyantoro C, Tan LT, Bozdech Z, Wang Z, Liang ZX.   +10 more
europepmc   +2 more sources

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

Memorias do Instituto Oswaldo Cruz, 2012
Artemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite
Luiz Francisco Rocha e Silva, Pedro Melillo de Magalhães, Mônica Regina Farias Costa, Maria das Graças Costa Alecrim, Francisco Célio Maia Chaves, Ari de Freitas Hidalgo, Adrian Martin Pohlit, Pedro Paulo Ribeiro Vieira   +7 more
doaj   +1 more source

Evaluation of the Antioxidant, Antidiabetic, and Antiplasmodial Activities of Xanthones Isolated from Garcinia forbesii and Their In Silico Studies

Biomedicines, 2021
This study aimed to isolate xanthones from Garcinia forbesii and evaluated their activity in vitro and in silico. The isolated compounds were evaluated for their antioxidant activity by DPPH, ABTS and FRAP methods. The antidiabetic activity was performed
Johanis Wairata, Edwin Risky Sukandar, Arif Fadlan, Adi Setyo Purnomo, Muhammad Taher, Taslim Ersam   +5 more
doaj   +1 more source

Antiplasmodial and analgesic activities of Clausena anisata

Asian Pacific Journal of Tropical Medicine, 2012
Antiplasmodial and analgesic activities of the leaf extract and fractions of Clausena anisata (C. anisata) were evaluated for antimalarial and analgesic activities.The crude leaf extract (39-117 mg/kg) and fractions (chloroform and acqeous; 78 mg/kg) of C.
Okokon, Jude E, Etebong, Ette O, Udobang, John A, Essien, Grace E   +3 more
openaire   +2 more sources

Antiplasmodial and antileishmanial flavonoids from Mundulea sericea

Fitoterapia, 2021
NMR FIDs for the isolated ...
Carolyne Chepkirui, Purity J. Ochieng, Biswajyoti Sarkar, Aabid Hussain, Chiranjib Pal, Li Yang, Paolo Coghi, Hoseah M. Akala, Solomon Derese, Albert Ndakala, Matthias Heydenreich, Vincent Kam Wai Wong, Máté Erdélyi, Abiy Yenesew   +13 more
openaire   +6 more sources