Results 11 to 20 of about 5,494 (181)

Co(II), Cu(II), and Ni(II) Coordination Complexes: Synthesis, Characterization, Experimental, and Computational Study on Potential Antiplasmodial Activity. [PDF]

ChemMedChem
Four isostructural complexes (C1–C4) derived from 2‐(tert‐butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine with axial halides exhibit octahedral trans M(L)4X2 geometries, confirmed by X‐ray diffraction. They feature a discrete 1,6M7−1 topology, identified using ToposPro analysis.
Ezenarro-Salcedo D, Fonseca-López D, Patiño-Cubides A, Velasco-Pareja MC, Yasnot-Acosta MF, Serrano-Sterling C, Rodríguez A, Macías MA, Orjuela AL, Valderrama-Aguirre A, Hurtado JJ.   +10 more
europepmc   +2 more sources

Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones [PDF]

Molecules, 2021
Malaria is one of the most dangerous infectious diseases. Because the causative Plasmodium parasites have developed resistances against virtually all established antimalarial drugs, novel antiplasmodial agents are required. In order to target plasmodial kinases, novel N-unsubstituted bisindolylcyclobutenediones were designed as analogs to the kinase ...
Duc Hoàng Lande, Abed Nasereddin, Arne Alder, Tim W. Gilberger, Ron Dzikowski, Johann Grünefeld, Conrad Kunick   +6 more
openaire   +5 more sources

Synthesis, Characterization, and Anti-Plasmodium falciparum Activity of a New Copper(II) Complex Containing 2-(Tert-Butoxy)-6-(1H-imidazol-1-yl)pyridine. [PDF]

ChemMedChem
The graphical abstract illustrates the formation of a Cu(II) complex from azole‐based ligand, highlighting metal–ligand synergy. The resulting coordination compound acts as a bioactive entity against Plasmodium, where metal coordination enhances antiparasitic activity, outperforming the free ligand and demonstrating its potential as an antimalarial ...
Patiño-Cubides A, Velasco-Pareja MC, Macías MA, Yasnot-Acosta MF, Rodriguez A, Valderrama-Aguirre A, Hurtado JJ.   +6 more
europepmc   +2 more sources

Antiplasmodial natural products: an update [PDF]

Malaria Journal, 2019
Abstract Background Malaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination ...
Nasir Tajuddeen, Fanie R. Van Heerden
openaire   +3 more sources

In vitro antiplasmodial activity of cepharanthine [PDF]

Malaria Journal, 2014
New classes of anti-malarial drugs are needed to control the alarming Plasmodium falciparum resistance toward current anti-malarial therapy. The ethnopharmacological approach allows the discovery of original chemical structures from the vegetable biodiversity.
Desgrouas, Camille, Chapus, Charles, Desplans, Jérôme, Travaille, Christelle, Pascual, Aurélie, Baghdikian, Béatrice, Ollivier, Evelyne, Parzy, Daniel, Taudon, Nicolas   +8 more
openaire   +2 more sources

Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

Metabolites, 2023
The chemical investigation of the EtOH extract from the stem bark of Trichilia monadelpha (Thonn.) J. J. De Wilde afforded two new limonoids (1 and 2): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (1) and (6R)-1-O-deacetylkhayanolide E (2 ...
Arnauld Kenfack Djoumessi, Raymond Ngansop Nono, Beate Neumann, Hans-Georg Stammler, Gabin Thierry Mbahbou Bitchagno, Noella Molisa Efange, Celine Nguefeu Nkenfou, Lawrence Ayong, Bruno Ndjakou Lenta, Norbert Sewald, Pépin Nkeng-Efouet-Alango, Jean Rodolphe Chouna   +11 more
doaj   +1 more source

Breynia cernua: Chemical Profiling of Volatile Compounds in the Stem Extract and Its Antioxidant, Antibacterial, Antiplasmodial and Anticancer Activity In Vitro and In Silico

Metabolites, 2023
Breynia cernua has been used as an alternative medicine for wounds, smallpox, cervical cancer, and breast cancer. This plant is a potential source of new plant-derived drugs to cure numerous diseases for its multiple therapeutic functions.
Hesti Lina Wiraswati, Nisa Fauziah, Gita Widya Pradini, Dikdik Kurnia, Reza Abdul Kodir, Afiat Berbudi, Annisa Retno Arimdayu, Amila Laelalugina, Supandi, Ilma Fauziah Ma'ruf   +9 more
doaj   +1 more source

Antiplasmodial activity against resistant strains, toxicity and effect on mouse liver enzymes of extracts of Terminalia species found in Southwest Cameroon [PDF]

Journal of HerbMed Pharmacology, 2021
Introduction: Terminalia species have the potential to be exploited in phytomedicine based on their several pharmacological properties including antiplasmodial activity.
Moses Njutain Ngemenya, Grace Ntube Abwenzoh, Denis Zofou, Thierry Roland Kang, James Ajeck Mbah   +4 more
doaj   +1 more source

Antiplasmodial and antiulcer activities of Melanthera scadens [PDF]

Asian Pacific Journal of Tropical Biomedicine, 2012
To evaluate the antimalarial and antiulcerogenic activities of leaf extract and fractions of Melanthera scandens (M. scandens).The crude leaf extract (37-111 mg/kg) and fractions (chloroform, ethylacetate and methanol; 78 mg/kg) of M. scadens were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei infections in ...
Jude E, Okokon, Ette O, Etebong, John A, Udobang, Jackson, Obot   +3 more
openaire   +2 more sources

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

Molecules, 2017
Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5–11), were isolated from the CH2Cl2/MeOH (1:1 ...
Yoseph Atilaw, Lois Muiva-Mutisya, Albert Ndakala, Hoseah M. Akala, Redemptah Yeda, Yu J. Wu, Paolo Coghi, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew   +9 more
doaj   +1 more source