Results 11 to 20 of about 2,581 (172)
Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceTrypanosomiasis is a parasitic disease for which new treatments are needed due to the frequent occurrence of adverse side effects of current available drugs.
Lúcia Mamede +9 more
doaj +2 more sources
Molecules, 2021 The in vitro activity of L. donovani (promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells) and T. brucei, from the fractions obtained from the hydroalcoholic extract of the aerial part of Hypericum afrum and the isolated ...
Farida Larit +6 more
doaj +1 more source
Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety. [PDF]
PLoS ONE, 2018 The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents.
David Izuchukwu Ugwu +2 more
doaj +1 more source
Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis
Molecules, 2021 The search for novel antitrypanosomals and the investigation into their mode of action remain crucial due to the toxicity and resistance of commercially available antitrypanosomal drugs.
Aboagye Kwarteng Dofuor +4 more
doaj +1 more source
Nitroquinolones and nitroquinolines: syntheses and antitrypanosomal activity. [PDF]
Mol DiversNitroaromatic small molecules are established anti-infectives, including against trypanosomal diseases. Inspired by our previously identified suicide inhibitors of Mycobacterium tuberculosis (Mtb) decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1), we report the synthesis and in vitro antitrypanosomal activity of six novel nitroquinoline derivatives (
Dube PS +7 more
europepmc +3 more sources
Molecules, 2022 New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials ...
Darline Dize +12 more
doaj +1 more source
Molecules, 2022 Trypanosomiasis and leishmaniasis are among the major neglected diseases that affect poor people, mainly in developing countries. In Ethiopia, the latex of Aloe rugosifolia Gilbert & Sebsebe is traditionally used for the treatment of protozoal diseases ...
Gete Chemeda +3 more
doaj +1 more source
Antitrypanosomal Activities of Tryptanthrins [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT New drugs and molecular targets are needed against Trypanosoma brucei , the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro.
John, Scovill +4 more
openaire +2 more sources
Antitrypanosomal Activity of Fluoroquinolones [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Six fluoroquinolones presently in clinical use and four investigational tetracyclic fluoroquinolones were tested for in vitro activity against bloodstream-form Trypanosoma brucei brucei . All compounds had measurable activity, but the tetracyclic analogs were most potent, with 50% effective ...
E, Nenortas, C, Burri, T A, Shapiro
openaire +2 more sources
Molecules, 2022 In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the Crassulaceae family have been selected for the present study.
Mostafa M. Hegazy +11 more
doaj +1 more source