Results 41 to 50 of about 2,581 (172)
Advances in Pharmacological and Pharmaceutical Sciences, 2022 Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (female Anopheles mosquito and tsetse fly) abound.
Aboagye Kwarteng Dofuor +3 more
doaj +1 more source
Histone Deacetylases As Targets for Antitrypanosomal Drugs
Future Science OA, 2018 Parasitic protozoa comprise several species that are causative agents of important diseases. These diseases are distributed throughout the world and include leishmaniasis, Chagas disease and sleeping sickness, malaria and toxoplasmosis. Treatment is based on drugs that were developed many years ago, which have side effects and produce resistant ...
Zuma, Aline A, de Souza, Wanderley
openaire +2 more sources
Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge Callyspongia siphonella
Marine Drugs, 2019 In the present study, LC-HRESIMS-assisted dereplication along with bioactivity-guided isolation led to targeting two brominated oxindole alkaloids (compounds 1 and 2) which probably play a key role in the previously reported antibacterial, antibiofilm ...
Seham S. El-Hawary +12 more
doaj +1 more source
In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei
Advances in Pharmacological and Pharmaceutical Sciences, 2022 African trypanosomiasis is a major neglected tropical disease with significant health and economic concerns in sub-Saharan Africa. In the absence of vaccines for African trypanosomiasis, there is a consideration for alternative sources of chemotherapy ...
Aboagye Kwarteng Dofuor +4 more
doaj +1 more source
Antileishmanial and Antitrypanosomes Drugs for the Current Century
Microorganisms, 2023 Human infections by trypanosomatids are widely distributed and prevalent in the tropical and subtropical regions. Diseases caused by Trypanosoma and Leishmania have variable clinical outcomes, ranging from self-healing to fatality, and are considered Neglected Tropical Diseases (NTD).
openaire +5 more sources
Molecules, 2013 Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of ...
Louis Maes +9 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira +4 more
wiley +1 more source
Molecules, 2012 Malaria, leishmaniasis and human African trypanosomiasis continue to be major public health problems in need of new and more effective drugs. The aim of this study was to evaluate in vitro antiprotozoal activity of twenty endemic medicinal plants ...
Louis Maes +4 more
doaj +1 more source
Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto +9 more
wiley +1 more source
Molecules, 2013 Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3–
Louis Maes +4 more
doaj +1 more source