Results 31 to 40 of about 2,581 (172)
Antitrypanosomal Activity of Sinefungin
The American Journal of Tropical Medicine and Hygiene, 1983 Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5' of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense.
Dube, D.K. +4 more
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Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid
Elizabeth, Nenortas +3 more
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Pharmacological Approaches to Antitrypanosomal Chemotherapy [PDF]
Memórias do Instituto Oswaldo Cruz, 1999 There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and inhibitors of trypanosomatid glycosomal enzymes, trypanothione reductase, ornithine decarboxylase, S ...
openaire +5 more sources
Evaluation of quinolone derivatives for antitrypanosomal activity [PDF]
Tropical Medicine & International Health, 2001 About 160 fluoroquinolones and derivatives were tested for antitrypanosomal activity in a drug sensitivity assay followed by fluorometric evaluation. The most active quinolone compounds had IC50 values in the range from 100 to 900 ng/ml, while several derivatives were not active at a concentration of 100 μg/ml.
Keiser J, Burri C
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Enantiospecific antitrypanosomal in vitro activity of eflornithine
PLOS Neglected Tropical Diseases, 2021 The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage. This parasitic disease, transmitted by the tsetse fly, is lethal unless treated. Eflornithine is administered by repeated intravenous infusions as a racemic mixture of L-eflornithine and D ...
Mikael Boberg +5 more
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Molecules, 2021 As part of our studies on antiprotozoal activity of approved herbal medicinal products, we previously found that a commercial tincture from Salvia officinalis L. (common Sage, Lamiaceae) possesses high activity against Trypanosoma brucei rhodesiense (Tbr)
Núria Llurba Montesino +3 more
doaj +1 more source
Antitrypanosomal butanolides from Aiouea trinervis
EXCLI journal, 2020 EXCLI Journal;Vol.
Nunes, Felipe Oliveira +6 more
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In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei
Journal of Traditional and Complementary Medicine, 2022 Background and aim: African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from B.
Aboagye Kwarteng Dofuor +11 more
doaj +1 more source
Journal of Parasitology Research, 2021 Introduction. Trypanosomiasis is one of the world’s most serious infectious diseases caused by Trypanosoma parasites. Concern about resistance to conventional antitrypanosomal drugs, mosquito vector resistance to existing insecticide side effects of ...
Debela Abdeta +4 more
doaj +1 more source
Marine Drugs, 2014 The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol.
Christina Viegelmann +8 more
doaj +1 more source