Results 21 to 30 of about 2,581 (172)

Antineoplastic and Antitrypanosomal Properties of Propolis from Tetragonula biroi Friese

Molecules, 2022
Propolis, popularly known as bee glue, is a resinous, sticky substance produced by different bee species across the globe. Studies on the biological properties of propolis from the Philippines are rare.
Samyah Alanazi
doaj   +1 more source

Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Antibiotics, 2023
In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in
Oluwatofunmilayo A. Diyaolu, Gagan Preet, Adeshola A. Fagbemi, Frederick Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Olusoji O. Adebisi, Emmanuel T. Oluwabusola, Bruce F. Milne, Marcel Jaspars, Rainer Ebel   +10 more
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Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
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Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling

Antibiotics, 2020
In the present study, we investigated the actinomycetes associated with the Red Sea-derived soft coral Sarcophyton glaucum in terms of biological and chemical diversity. Three strains were cultivated and identified to be members of genera Micromonospora,
Noha M. Gamaleldin, Walid Bakeer, Ahmed M. Sayed, Yara I. Shamikh, Ahmed O. El-Gendy, Hossam M. Hassan, Hannes Horn, Usama Ramadan Abdelmohsen, Wael N. Hozzein   +8 more
doaj   +1 more source

Antitrypanosomal Activities of Proteasome Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells.
Njinkeng Joseph, Nkemngu, Joseph, Nkemgu-Njinkeng, Vera, Rosenkranz, Michael, Wink, Dietmar, Steverding   +4 more
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In Vitro Assessment of Antiplasmodial and Antitrypanosomal Activities of Chloroform, Ethyl Acetate and Ethanol Leaf Extracts of Oedera genistifolia

Applied Sciences, 2020
The high resistance evolution of protozoans to the existing antiparasitic drugs has necessitated the quest for novel and effective drugs against plasmodium and trypanosome parasites.
Kunle Okaiyeto, Anthony I. Okoh
doaj   +1 more source

Structure-Activity Relationship Study of Sesquiterpene Lactones and Their Semi-Synthetic Amino Derivatives as Potential Antitrypanosomal Products

Molecules, 2014
Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis.
Stefanie Zimmermann, Gerda Fouché, Maria De Mieri, Yukiko Yoshimoto, Toyonobu Usuki, Rudzani Nthambeleni, Christopher J. Parkinson, Christiaan van der Westhuyzen, Marcel Kaiser, Matthias Hamburger, Michael Adams   +10 more
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Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

Frontiers in Pharmacology, 2020
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo, Karlos Eduardo Pianoski, Mariellen Guilherme dos Santos, Danielle Lazarin-Bidóia, Hélito Volpato, Sidnei Moura, Celso Vataru Nakamura, Fernanda Andreia Rosa   +7 more
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Synthesis and antitrypanosomal activities of novel pyridylchalcones [PDF]

European Journal of Medicinal Chemistry, 2017
A library of novel pyridylchalcones were synthesised and screened against Trypanosoma brucei rhodesiense. Eight were shown to have good activity with the most potent 8 having an IC50 value of 0.29 μM. Cytotoxicity testing with human KB cells showed a good selectivity profile for this compound with a selectivity index of 47.
Bhambra, Avninder S., Ruparelia, K. C., Tan, Hoon Leong, Tasdemir, D., Burrell-Saward, H., Yardley, Vanessa, Beresford, Kenneth J. M., Arroo, R. R. J.   +7 more
openaire   +2 more sources

Chagas disease treatment efficacy markers: experiences from a Phase III study with nifurtimox in children

Frontiers in Parasitology, 2023
Determining the success of antitrypanosomal therapy for Chagas disease is challenging, particularly in the chronic phase of the disease, because seropositivity persists for a long time after successful antitrypanosomal treatment and is known to be ...
Ulrike Grossmann, Maria-Luisa Rodriguez
doaj   +1 more source