Results 61 to 70 of about 2,581 (172)

Antitrypanosomal activity of Argemone mexicana extract and fractions in the animal model of Trypanosoma brucei brucei infection

Open Veterinary Science, 2022
This study investigated the antitrypanosomal activity of Argemone mexicana extract and fractions in the animal model of Trypanosoma brucei brucei infection.
Chukwu Ifeoma L., Ugwu Malachy C., Iroha Ifeanyi R., Mbagwu Ikechukwu S., Okafor Ugochukwu U., Ajaghaku Amara A.   +5 more
doaj   +1 more source

Using deep learning to assess the toxicological effects of sublethal exposure of a novel green pesticide in a stored‐product beetle

Pest Management Science, Volume 82, Issue 5, Page 4319-4331, May 2026.
This study employs an AI‐driven multidisciplinary approach to increase our understanding of the toxicological effects of sublethal concentrations of carlina oxide on Prostephanus truncatus. Sublethal exposure to the carlina oxide induced changes in motor patterns and thigmotaxis, highlighting its potential role in integrated pest management strategies.
Anita Casadei, Maria C. Boukouvala, Gianluca Manduca, Nickolas G. Kavallieratos, Filippo Maggi, Marta Ferrati, Eleonora Spinozzi, Cesare Stefanini, Antonio DeSimone, Donato Romano   +9 more
wiley   +1 more source

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones.

PLoS ONE, 2023
Severe infections with potentially fatal outcomes are caused by parasites from the genera Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote areas in the tropics and subtropics with limited access to adequate health ...
Irina Ihnatenko, Marco J Müller, Oliver C F Orban, Jens C Lindhof, Diego Benítez, Cecilia Ortíz, Estefanía Dibello, Leonardo L Seidl, Marcelo A Comini, Conrad Kunick   +9 more
doaj   +1 more source

Diminazene Aceturate Ameliorates Hypertension‐Induced Cognitive Impairment by Disrupting the CCN1–Integrin αvβ6–TGF‐β Axis and Preserving Mitochondrial Integrity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Hypertension drives cognitive decline through a previously unrecognized CCN1–integrin αvβ6–TGF‐β signaling axis that culminates in mitochondrial dysfunction and hippocampal neuronal injury. In this pathway, angiotensin II induces CCN1 upregulation, which activates αvβ6 integrin‐mediated release of latent TGF‐β, triggering SMAD2/3 phosphorylation and ...
Xufang Huo, Zhenyu Wu, Xinqian Zhou, Yuancheng Zhou, Jiming Liu, Hongbing Li, Yijiu Wu, You Huang, Guangling Feng, Xiaolin Hu, Qingfan Zeng   +10 more
wiley   +1 more source

Isolation of Antitrypanosomal Compounds from , a Medicinal Plant of Myanmar

Natural Product Communications, 2012
Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol ( 1 ), 11- O -acetyl bergenin ( 2 ), and stigmast-4-en-3-one ( 3 ).
Khine Swe Nyunt, Ahmed Elkhateeb, Yusuke Tosa, Kensuke Nabata, Ken Katakura, Hideyuki Matsuura   +5 more
doaj   +1 more source

Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Molecules, 2020
The MeOH/CH2Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei.
Christine C. Waleguele, Brice M. Mba’ning, Angelbert F. Awantu, Jean J. K. Bankeu, Yannick S. F. Fongang, Augustin S. Ngouela, Etienne Tsamo, Norbert Sewald, Bruno N. Lenta, Rui W. M. Krause   +9 more
doaj   +1 more source

New Class of Antitrypanosomal Agents Based on Imidazopyridines [PDF]

ACS Medicinal Chemistry Letters, 2017
The present work describes the synthesis of 22 new imidazopyridine analogues arising from medicinal chemistry optimization at different sites on the molecule. Seven and 12 compounds exhibited an in vitro EC50 ≤ 1 μM against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) parasites, respectively.
Daniel G. Silva, J. Robert Gillespie, Ranae M. Ranade, Zackary M. Herbst, Uyen T. T. Nguyen, Frederick S. Buckner, Carlos A. Montanari, Michael H. Gelb   +7 more
openaire   +2 more sources

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Antitrypanosomal Activity of Novel Benzaldehyde-Thiosemicarbazone Derivatives from Kaurenoic Acid †

Molecules, 2011
A series of new thiosemicarbazones derived from natural diterpene kaurenoic acid were synthesized and tested against the epimastigote forms of Trypanosoma cruzi to evaluate their antitrypanosomal potential.
Cecília M. A. de Oliveira, Celso V. Nakamura, Raissa B. Pedroso, Francielle P. Garcia, Phercyles V. dos Santos, Gentil J. Vidotti, Adriano A. Silva, Shirani K. Haraguchi, Cleuza C. da Silva   +8 more
doaj   +1 more source

Ethnomedicinal Evidence for Medicinal Plants of the Asteraceae Family Used by Tanzanians to Treat Various Ailments: A Review

BioMed Research International, Volume 2026, Issue 1, 2026.
The Asteraceae family is amongst the most important groups of flowering plants, widely recognised for its ethnomedicinal relevance. This systematic review, conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, synthesises evidence on the traditional medicinal uses of Asteraceae species in ...
David Sylvester Kacholi, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source