Results 71 to 80 of about 2,581 (172)

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives

Bioorganic & Medicinal Chemistry Letters, 2012
In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties.
Pérez Cruz, F, SERRA, SILVIA, DELOGU, GIOVANNA LUCIA, Lapier, M, Maya, Jd, Olea Azar, C, Santana, L, Uriarte, E.   +7 more
openaire   +7 more sources

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

Molecules, 2018
As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena ...
Charles Okeke Nnadi, Julia Barbara Althaus, Ngozi Justina Nwodo, Thomas Jürgen Schmidt   +3 more
doaj   +1 more source

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.

PLoS Neglected Tropical Diseases, 2018
Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially characterised.
James A Thomas, Nicola Baker, Sebastian Hutchinson, Caia Dominicus, Anna Trenaman, Lucy Glover, Sam Alsford, David Horn   +7 more
doaj   +1 more source

Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents.

PLoS Neglected Tropical Diseases, 2020
BackgroundGhana is endemic for some neglected tropical diseases (NTDs) including schistosomiasis, onchocerciasis and lymphatic filariasis. The major intervention for these diseases is mass drug administration of a few repeatedly recycled drugs which is a
Emmanuella Bema Twumasi, Pearl Ihuoma Akazue, Kwaku Kyeremeh, Theresa Manful Gwira, Jennifer Keiser, Fidelis Cho-Ngwa, Adrian Flint, Barbara Anibea, Emmanuel Yeboah Bonsu, Richard K Amewu, Linda Eva Amoah, Regina Appiah-Opong, Dorcas Osei-Safo   +12 more
doaj   +1 more source

Evaluating the influence of trypanosomiasis on murine model using Corchorus olitorius leaf extract as a trypanocidal agent [PDF]

Bulletin of Natural Sciences Research
Trypanosomiasis, a parasitic disease caused by trypanosomes, which are flagellate protozoa transmitted through the bite of the tsetse fly, manifests with symptoms including substantial weight loss, anemia, fever, edema, adenitis, dermatitis, and nervous ...
Madaki Fatima M., Adamu Kabiru Y., Ogunrombi Clinton D., Sakariyau Waheed A., Yunusa Ibrahim O.   +4 more
doaj   +1 more source

Evaluation of the Antitrypanosomal Activity of the Crude Extracts of Uvaria Ovata: In vitro and In silico Approach

Biomedical and Biotechnology Research Journal
Background: Human African trypanosomiasis is the third disease with most mortalities among the neglected tropical diseases. The absence of vaccines and the development of parasite resistance have necessitated the quest for new affordable and safe ...
Mary Anti Chama, Beverly Egyir, Kofi Baffour-Awuah Owusu, Jessica Asomaniwaa Armah, Michael Afiadenyo, Samuel Kojo Kwofie   +5 more
doaj   +1 more source

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

Molecules, 2015
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah   +4 more
doaj   +1 more source

An In vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl

Heliyon
African Trypanosomiasis caused by trypanosome parasites continues to be a major neglected health problem, particularly in developing countries. Current treatments are marked by serious side effects, low effectiveness, high toxicity, and drug resistance ...
Latif Adams, Dorcas Obiri-Yeboah, Michael Afiadenyo, Sherif Hamidu, Abigail Aning, Ebenezer Ehun, Katie Shiels, Akanksha Joshi, Maxwell Mamfe Sakyimah, Kwadwo Asamoah Kusi, Irene Ayi, Michelle Mckeon Bennett, Siobhan Moane   +12 more
doaj   +1 more source

Anti-Trypanosomal Alkaloids from

Natural Product Communications, 2006
From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid ( 1 ), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N ...
Dieudonne Ngamga, Pierre Tane, Donna Rattendi, Cyrus Bacchi, Christopher C. Okunji, Maurice M. Iwu, Brian M. Schuster, Olov Sterner   +7 more
doaj   +1 more source