Synthesis, in-vitro antitubercular, antifungal activities and in silico molecular docking study of Chalcone derivatives from 1-(2'-Hydroxyphenyl)-3-(substituted-phenyl)-2-propenone. [PDF]
Microbes and Infectious Diseases, 2023 Background: Tuberculosis (TB) is one of the major global health problems and faced to the increased resistance of Mycobacterium tuberculosis strains against existing antitubercular agents, it is important to look for new antitubercular drugs.
Arnold Mulula +4 more
doaj +1 more source
Microbiology Spectrum, 2023 We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett +7 more
doaj +1 more source
Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal +3 more
doaj +1 more source
Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized.
Sharma Ritu +3 more
doaj +1 more source
Pharmaceutics, 2022 The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors.
Penelope N. Rampedi +3 more
doaj +1 more source
Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts
Medicines, 2022 Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative ...
Kojo Sekyi Acquah +6 more
doaj +1 more source
Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report [PDF]
Annals of Coloproctology, 2021 Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions.
Sung Hoon Kang +10 more
doaj +1 more source
Tricyanated Ferrocenes; Isolation, structure, electrochemistry and DFT calculations
Zeitschrift für anorganische und allgemeine Chemie, Volume 649, Issue 1, January 2, 2023., 2023 Abstract 1,2,3‐ Tricyanoferrocene and 1,3‐dibromo‐2,4,5‐tricyanoferrocene have been synthesized via metallation and usage of dimethylmalononitrile (DMMN) as cyanating agent. They are the first compounds where three nitrile functions could be introduced into the ferrocene sceleton.
Tobias Blockhaus +4 more
wiley +1 more source
Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
Pharmaceuticals, 2020 This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina +3 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source