Results 1 to 10 of about 49,938 (301)

Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]

Journal of the Serbian Chemical Society, 2012
A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal, Sharma Ritu, Srivastava Santosh K., Srivastava Savitri D.   +3 more
doaj   +3 more sources

Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities

Molecules, 2020
Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik, Richie R. Bhandare, Srinath Nissankararao, Zehra Edis, N. Ravikiran Tangirala, Shaik Shahanaaz, M. Mukhlesur Rahman   +6 more
doaj   +2 more sources

Central Nervous System Infections Caused by Bacillus Calmette-Guerin: Case Report and Narrative Literature Review. [PDF]

Microorganisms
Bacillus Calmette–Guerin (BCG) central nervous system (CNS) infections are one of the rarest complications following BCG exposure. A 77-year-old male, with bladder cancer previously treated with BCG instillation, presented with fever, confusion, and ...
Chemello D, Albertini M, Chester J, Esperti S, Ghidoni E, Orlando G, Franceschi G, Iaccarino C, Lucchesi L, Pavesi G, Mussini C, Franceschini E.   +11 more
europepmc   +2 more sources

Prediction of Antitubercular Peptides From Sequence Information Using Ensemble Classifier and Hybrid Features

Frontiers in Pharmacology, 2018
Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of drug resistant strains. Antitubercular peptides may provide an alternate approach to combat antibiotic tolerance.
Salman Sadullah Usmani, Salman Sadullah Usmani, Sherry Bhalla, Gajendra P. S. Raghava, Gajendra P. S. Raghava   +4 more
doaj   +2 more sources

Structural isomerisation affects the antitubercular activity of adamantyl-isoxyl adducts. [PDF]

J Enzyme Inhib Med Chem
Despite efforts to discover effective treatments to eradicate tuberculosis (TB), it remains a global threat. The increase in drug-resistant bacterial species has made the discovery of new drugs highly coveted.
Lu Y, Partleton D, Gugu FM, Alhejaili AYG, Norris S, Harburn JJ, Gill JH, Sellars JD, Brown AK.   +8 more
europepmc   +2 more sources

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies

Molecules, 2020
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira, Cristina Ventura, José R. B. Gomes, Paula Gomes, Filomena Martins   +4 more
doaj   +2 more sources

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill, A Koul, AE Grzegorzewicz, Alfonso Mendoza-Losana, Anil Kumar Tyagi, C Dye, C Varela, Carlos Alemparte, Carolina González, Chrystala Constantinidou, CK Stover, David Barros, David J. Dow, DJ Payne, Douglas J. Minick, Elena Jiménez, Esther Pérez-Herrán, Fátima Ortega-Muro, Gurdyal S. Besra, Iñigo Angulo-Barturen, JA Maddry, Joaquín Rullás, Johnson Afari, Jorge Esquivias, K Andries, K Pethe, K Tahlan, LL Ballell, Lluís Ballell, M Berry, M Biava, M Murray, M Protopopova, Mark J. Pallen, María José Rebollo-López, María Martínez-Hoyos, María Teresa Fraile-Gabaldón, Modesto J. Remuiñán, Mónica Cacho, Nalini Mehta, Nicholas Cammack, Nicholas J. Loman, R Singh, SA Stanley, ST Cole, V La Rosa, V Makarov, Verónica Sousa, Vickey L. Spivey   +48 more
core   +18 more sources

Synthesis, in-vitro antitubercular, antifungal activities and in silico molecular docking study of Chalcone derivatives from 1-(2'-Hydroxyphenyl)-3-(substituted-phenyl)-2-propenone. [PDF]

Microbes and Infectious Diseases, 2023
Background:  Tuberculosis (TB) is one of the major global health problems and faced to the increased resistance of Mycobacterium tuberculosis strains against existing antitubercular agents, it is important to look for new antitubercular drugs.
Arnold Mulula, Abdeldjalil Bouzina, Hugues Mambu, Gracia Mbiye, Ahmed Zaki   +4 more
doaj   +1 more source

A Case Report on Organic Psychosis Induced by Antitubercular Drugs in A Young Female

Asian Journal of Hospital Pharmacy, 2023
Antitubercular drugs including rifampicin, isoniazid and pyrazinamide can cause rare but severe adverse effects involving the central nervous system. Neuropsychiatric side effects ranging from headache to psychosis have been reported.
Prakash Nathaniel Kumar Sarella, Janki Pavanilakshmi Dadishetti, Patrick Oliver Asogwa, Ravishankar Kakarparthy   +3 more
semanticscholar   +1 more source

QSAR modeling, molecular docking, dynamic simulation and ADMET study of novel tetrahydronaphthalene derivatives as potent antitubercular agents

Beni-Suef University Journal of Basic and Applied Sciences, 2023
Tuberculosis is an air-borne contagious disease caused by slow-growing Mycobacterium tuberculosis (Mtb). According to Global Tuberculosis Report 2022, 1.6 million people were infected by tuberculosis in 2021.
Anguraj Moulishankar, T. Sundarrajan
semanticscholar   +1 more source