Results 11 to 20 of about 49,938 (301)

Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones [PDF]

Molecules, 2017
Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini, Guilherme S. Torrezan, Vanessa R. Santos, Ana C. Nazaré, Débora L. Campos, Laíza A. Almeida, Isabel C. Silva, Henrique Ferreira, Fernando R. Pavan, Cristiane Duque, Luis O. Regasini   +10 more
doaj   +5 more sources

The Bewildering Antitubercular Action of Pyrazinamide [PDF]

Microbiology and Molecular Biology Reviews, 2020
Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease relapse rates, PZA is considered an irreplaceable component of ...
E. Lamont, N. Dillon, Anthony D. Baughn
semanticscholar   +4 more sources

Antitubercular drug poisoning in a pregnant woman

Indian Journal of Anaesthesia, 2010
A 20-year-old female in her third month of pregnancy, presented with generalised tonic clonic seizures, metabolic acidosis and coma following suicidal ingestion of antitubercular medication.
Rahul Dutta, Surya Kumar Dube, Dinesh Kumar Singh   +2 more
doaj   +4 more sources

Pyrimidine derivatives with antitubercular activity.

European Journal of Medicinal Chemistry, 2022
Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials. This review provides an overview of recent advances in the hit-to-lead drug discovery studies of antitubercular pyrimidine ...
Vladimir Finger, M. Kufa, O. Soukup, D. Castagnolo, Jaroslav Roh, J. Korábečný   +5 more
semanticscholar   +4 more sources

Ionophoric effects of the antitubercular drug bedaquiline [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Antibiotics generally target one of five essential cellular functions in bacteria, but many of these targets are now compromised through rapidly spreading antibiotic resistance.
Kiel Hards, D. G. McMillan, L. Schurig-Briccio, R. Gennis, H. Lill, D. Bald, G. Cook   +6 more
semanticscholar   +7 more sources

Recent Advances in Research on Antituberculars [PDF]

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Bhairab Nath Roy, Madhavi A. Karnik, Sankaran Ramesh   +2 more
openalex   +4 more sources

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

bioRxiv, 2022
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified.
E. Nuermberger, María S Martínez-Martínez, O. Sanz, Beatriz Urones, J. Esquivias, H. Soni, R. Tasneen, S. Tyagi, Si-yang Li, P. Converse, H. Boshoff, G. Robertson, G. Besra, Katherine A Abrahams, A. Upton, K. Mdluli, G. Boyle, S. Turner, N. Fotouhi, N. Cammack, Juan Miguel Siles, Marta Alonso, J. Escribano, J. Lelièvre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, E. Jiménez   +30 more
semanticscholar   +1 more source

Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

Microbiology Spectrum, 2023
We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo, Tanya Parish   +7 more
doaj   +1 more source

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

Pharmaceuticals, 2022
A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step.
Rashmika Moodley, Chakes Mashaba, Goitsemodimo H. Rakodi, Nomagugu B. Ncube, M. V. Maphoru, M. Balogun, Audrey Jordan, D. Warner, René Khan, Matshawandile Tukulula   +9 more
semanticscholar   +1 more source

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies

PLoS ONE, 2022
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu, R. Yejella, Srinath Nissankararao, Richie R. Bhandare, Venu Sampath Kumar Golla, Bontha Venkata Subrahmanya Lokesh, M. M. Rahman, A. Shaik   +7 more
semanticscholar   +1 more source