Results 11 to 20 of about 35,652 (265)
Pyrimidine derivatives with antitubercular activity.
European Journal of Medicinal Chemistry, 2022 Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials. This review provides an overview of recent advances in the hit-to-lead drug discovery studies of antitubercular pyrimidine ...
Vladimir Finger +5 more
semanticscholar +4 more sources
The Bewildering Antitubercular Action of Pyrazinamide [PDF]
Microbiology and Molecular Biology Reviews, 2020 Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease relapse rates, PZA is considered an irreplaceable component of ...
E. Lamont, N. Dillon, Anthony D. Baughn
semanticscholar +4 more sources
Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones [PDF]
Molecules, 2017 Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini +10 more
doaj +5 more sources
Molecules, 2020 Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik +6 more
doaj +2 more sources
Antitubercular drug poisoning in a pregnant woman
Indian Journal of Anaesthesia, 2010 A 20-year-old female in her third month of pregnancy, presented with generalised tonic clonic seizures, metabolic acidosis and coma following suicidal ingestion of antitubercular medication.
Rahul Dutta +2 more
doaj +4 more sources
Ionophoric effects of the antitubercular drug bedaquiline [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Antibiotics generally target one of five essential cellular functions in bacteria, but many of these targets are now compromised through rapidly spreading antibiotic resistance.
Kiel Hards +6 more
semanticscholar +7 more sources
Molecules, 2018 The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12-O-deacetyl-12,19-di-epi-scalarin (14), a new scalarane sesterterpenoid, along with fourteen previously-reported ...
Abdulrahman M. Alahdal +6 more
doaj +2 more sources
Frontiers in Pharmacology, 2018 Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of drug resistant strains. Antitubercular peptides may provide an alternate approach to combat antibiotic tolerance.
Salman Sadullah Usmani +4 more
doaj +2 more sources
Molecules, 2020 Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira +4 more
doaj +2 more sources
Recent Advances in Research on Antituberculars [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Bhairab Nath Roy +2 more
openalex +5 more sources