Results 11 to 20 of about 50,974 (272)

A Rare Clinical Manifestation of Disseminated Tuberculosis: Case Report of Tuberculous Meningitis With Flaccid Paralysis. [PDF]

Clin Case Rep
ABSTRACT This case highlights a rare presentation of disseminated tuberculosis in a child, manifesting as tuberculous meningitis and flaccid paralysis due to spinal tuberculosis. Timely initiation of antitubercular therapy, corticosteroids, and ventriculoperitoneal shunt placement led to full recovery, emphasizing tuberculosis consideration in atypical
Haleem A, Ashraf S, Ahsan A, Qadri M, Shahid I, Ayalew BD.   +5 more
europepmc   +2 more sources

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

bioRxiv, 2022
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified.
E. Nuermberger, María S Martínez-Martínez, O. Sanz, Beatriz Urones, J. Esquivias, H. Soni, R. Tasneen, S. Tyagi, Si-yang Li, P. Converse, H. Boshoff, G. Robertson, G. Besra, Katherine A Abrahams, A. Upton, K. Mdluli, G. Boyle, S. Turner, N. Fotouhi, N. Cammack, Juan Miguel Siles, Marta Alonso, J. Escribano, J. Lelièvre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, E. Jiménez   +30 more
semanticscholar   +1 more source

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

Pharmaceuticals, 2022
A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step.
Rashmika Moodley, Chakes Mashaba, Goitsemodimo H. Rakodi, Nomagugu B. Ncube, M. V. Maphoru, M. Balogun, Audrey Jordan, D. Warner, René Khan, Matshawandile Tukulula   +9 more
semanticscholar   +1 more source

Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

Microbiology Spectrum, 2023
We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo, Tanya Parish   +7 more
doaj   +1 more source

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies

PLoS ONE, 2022
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu, R. Yejella, Srinath Nissankararao, Richie R. Bhandare, Venu Sampath Kumar Golla, Bontha Venkata Subrahmanya Lokesh, M. M. Rahman, A. Shaik   +7 more
semanticscholar   +1 more source

Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]

, 2020
Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca, da Costa, Ana M Rosa, Faleiro, Maria Leonor, Flórez Fernández, Noelia, Grenha, Ana, Rodrigues, Susana, Torres, María Dolores   +6 more
core   +1 more source

Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles

ACS Biomaterials Science & Engineering, 2021
Pretomanid and MCC7433, a novel nitroimidazopyrazinone analog, are promising antitubercular agents that belong to the bicyclic nitroimidazole family.
C. W. Ang, Lendl Tan, Zhi Qu, N. West, M. Cooper, A. Popat, M. Blaskovich   +6 more
semanticscholar   +1 more source

Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine [PDF]

Journal of the Serbian Chemical Society, 2012
A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized.
Sharma Ritu, Samadhiya Pushkal, Srivastava Savitri D., Srivastava Santosh K.   +3 more
doaj   +1 more source

Thiazole–Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation

Molecules, 2021
Compounds bearing thiazole and chalcone pharmacophores have been reported to possess excellent antitubercular and anticancer activities. In view of this, we designed, synthesized and characterized a novel series of thiazole–chalcone hybrids (1–20) and ...
Ashok Babu Kasetti, I. Singhvi, Ravindra Nagasuri, Richie R. Bhandare, A. Shaik   +4 more
semanticscholar   +1 more source

Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report [PDF]

Annals of Coloproctology, 2021
Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions.
Sung Hoon Kang, Hee Seok Moon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee, Jae Kyu Sung, Hyun Yong Jeong, Kyung Ha Lee   +10 more
doaj   +1 more source