Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal +3 more
doaj +3 more sources
Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives [PDF]
Molecules, 2015 A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H2SO4. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7 ...
Dong Cai +6 more
doaj +2 more sources
Tandem LC-MS Identification of Antitubercular Compounds in Zones of Growth Inhibition Produced by South African Filamentous Actinobacteria [PDF]
Molecules, 2023 Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
Daniel J. Watson +4 more
doaj +2 more sources
Antioxidant, Antitubercular and Cytotoxic Activities of Piper imperiale [PDF]
Molecules, 2012 Phenolic compounds are widely distributed in Nature and act as pharmacologically active constituents in many herbal medicines. They have multiple biological properties, most notably antioxidant, antibacterial and cytotoxic activities.
Sanjib Bhakta +6 more
doaj +2 more sources
Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies [PDF]
Molecules, 2020 Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira +4 more
doaj +2 more sources
Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]
, 2013 Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill +48 more
core +19 more sources
Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review [PDF]
MicroorganismsBacillus Calmette–Guerin (BCG) central nervous system (CNS) infections are one of the rarest complications following BCG exposure. A 77-year-old male, with bladder cancer previously treated with BCG instillation, presented with fever, confusion, and ...
Davide Chemello +11 more
doaj +2 more sources
A Rare Clinical Manifestation of Disseminated Tuberculosis: Case Report of Tuberculous Meningitis With Flaccid Paralysis. [PDF]
Clin Case RepABSTRACT This case highlights a rare presentation of disseminated tuberculosis in a child, manifesting as tuberculous meningitis and flaccid paralysis due to spinal tuberculosis. Timely initiation of antitubercular therapy, corticosteroids, and ventriculoperitoneal shunt placement led to full recovery, emphasizing tuberculosis consideration in atypical
Haleem A +5 more
europepmc +2 more sources
Pharmaceutics, 2022 The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors.
Penelope N. Rampedi +3 more
doaj +1 more source
Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts
Medicines, 2022 Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative ...
Kojo Sekyi Acquah +6 more
doaj +1 more source