Results 21 to 30 of about 35,652 (265)

A Case Report on Organic Psychosis Induced by Antitubercular Drugs in A Young Female

Asian Journal of Hospital Pharmacy, 2023
Antitubercular drugs including rifampicin, isoniazid and pyrazinamide can cause rare but severe adverse effects involving the central nervous system. Neuropsychiatric side effects ranging from headache to psychosis have been reported.
Prakash Nathaniel Kumar Sarella, Janki Pavanilakshmi Dadishetti, Patrick Oliver Asogwa, Ravishankar Kakarparthy   +3 more
semanticscholar   +1 more source

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

bioRxiv, 2022
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified.
E. Nuermberger, María S Martínez-Martínez, O. Sanz, Beatriz Urones, J. Esquivias, H. Soni, R. Tasneen, S. Tyagi, Si-yang Li, P. Converse, H. Boshoff, G. Robertson, G. Besra, Katherine A Abrahams, A. Upton, K. Mdluli, G. Boyle, S. Turner, N. Fotouhi, N. Cammack, Juan Miguel Siles, Marta Alonso, J. Escribano, J. Lelièvre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, E. Jiménez   +30 more
semanticscholar   +1 more source

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

Pharmaceuticals, 2022
A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step.
Rashmika Moodley, Chakes Mashaba, Goitsemodimo H. Rakodi, Nomagugu B. Ncube, M. V. Maphoru, M. Balogun, Audrey Jordan, D. Warner, René Khan, Matshawandile Tukulula   +9 more
semanticscholar   +1 more source

Thiazole–Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation

Molecules, 2021
Compounds bearing thiazole and chalcone pharmacophores have been reported to possess excellent antitubercular and anticancer activities. In view of this, we designed, synthesized and characterized a novel series of thiazole–chalcone hybrids (1–20) and ...
Ashok Babu Kasetti, I. Singhvi, Ravindra Nagasuri, Richie R. Bhandare, A. Shaik   +4 more
semanticscholar   +1 more source

Antitubercular pharmacodynamics of phenothiazines [PDF]

Journal of Antimicrobial Chemotherapy, 2012
Phenothiazines have been shown to exhibit in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb) and multidrug-resistant Mtb. They are predicted to target the genetically validated respiratory chain component type II NADH:quinone oxidoreductase (Ndh).
Neil G. Berry, Stephen A. Ward, Nicholas Fisher, Darren M. Moss, Teresa Rito, Paul M. O'Neill, Ashley J. Warman, Giancarlo A. Biagini   +7 more
openaire   +3 more sources

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

Pharmaceuticals, 2021
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established ...
M. Mori, G. Stelitano, L. Chiarelli, Giulia Cazzaniga, A. Gelain, D. Barlocco, E. Pini, F. Meneghetti, S. Villa   +8 more
semanticscholar   +1 more source

Exploration of Piperidinols as Potential Antitubercular Agents [PDF]

Molecules, 2014
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages.
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela Russell, Garrett Morris, Paul Finn, Edith Sim   +6 more
openaire   +6 more sources

Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives and Their Therapeutic Properties

Molecules, 2021
Antimicrobial resistance was one of the top priorities for global public health before the start of the 2019 coronavirus pandemic (COVID-19). Moreover, in this changing medical landscape due to COVID-19, finding new organic structures with antimicrobial ...
Maria Marinescu
doaj   +1 more source

ChCl: Gly (DESs) Promote Environmentally Benign Synthesis of Xanthene Derivatives and Their Antitubercular Activity

Molecules, 2021
A ChCl: Gly (DESs) promoted environmentally benign method was developed for the first time using the reaction of aryl aldehydes and dimedone to give excellent yields of xanthene analogues.
Mashooq A. Bhat, Ahmed M. Naglah, Siddique Akber Ansari, Hanaa M. Al-Tuwajiria, Abdullah Al-Dhfyan   +4 more
doaj   +1 more source

Pharmacovigilance of Antitubercular Therapy in Tuberculosis [PDF]

Cureus, 2022
Background Adverse drug reactions (ADRs) to tuberculosis (TB) drugs are a significant concern for medical professionals and health authorities. Adverse events due to drug-resistant TB (DRTB) treatment are among the most important reasons for treatment interruption. Methods This study was an observational study conducted among patients diagnosed with TB
Ravichandran, Mirunalini, Rajaram, Manju, Munusamy, Malathi   +2 more
openaire   +2 more sources