Results 21 to 30 of about 25,061 (213)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Tandem LC-MS Identification of Antitubercular Compounds in Zones of Growth Inhibition Produced by South African Filamentous Actinobacteria

Molecules, 2023
Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
Daniel J. Watson, Lubbe Wiesner, Tlhalefo Matimela, Denzil Beukes, Paul R. Meyers   +4 more
doaj   +1 more source

Mechanochemical Synthesis and Physicochemical Characterization of Isoniazid and Pyrazinamide Co-crystals With Glutaric Acid

Frontiers in Chemistry, 2020
The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of tuberculosis.
Jean Baptiste Ngilirabanga, Marique Aucamp, Paulo Pires Rosa, Halima Samsodien   +3 more
doaj   +1 more source

Antitubercular therapy-induced psychosis [PDF]

Neurology, 2019
A 12-year-old girl with multidrug-resistant pulmonary tuberculosis presented with a 5-day history of headache and psychosis; at the time, she was taking a complex antitubercular therapy (ATT; kanamycin, levofloxacin, ethionamide, pyrazinamide, cycloserine, ethambutol) and pyridoxine. Examination revealed fluctuating sensorium and aggression.
Jitendra Kumar Sahu, Bhanudeep Singanamala, Lokesh Saini, Paramjeet Singh, Pankaj C Vaidya, Priyanka Madaan   +5 more
openaire   +3 more sources

Novel Pyrimidines as Antitubercular Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2018
ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Srinivasan Kandasamy, Margareta Tuckman, Hsin Pin Ho, Alexander L. Perryman, Joel S. Freundlich, Nancy D. Connell, Pradeep Kumar, Steven D. Paget, Daigo Inoyama, Véronique Dartois, Eric Singleton, James L. Occi, Riccardo Russo, Matthew D. Zimmerman   +13 more
openaire   +3 more sources

Pyrimidine derivatives with antitubercular activity

European Journal of Medicinal Chemistry, 2023
Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials. This review provides an overview of recent advances in the hit-to-lead drug discovery studies of antitubercular pyrimidine ...
Vladimir Finger, Martin Kufa, Ondrej Soukup, Daniele Castagnolo, Jaroslav Roh, Jan Korabecny   +5 more
openaire   +3 more sources

Microbial glycosylation of antitubercular agent chlorflavonin [PDF]

Journal of Bioscience and Bioengineering, 2023
Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire   +3 more sources

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +1 more source

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives

Molecules, 2015
A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H2SO4. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7 ...
Dong Cai, Zhi-Hua Zhang, Yu Chen, Xin-Jia Yan, Liang-Jing Zou, Ya-Xin Wang, Xue-Qi Liu   +6 more
doaj   +1 more source

Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities

Molecules, 2020
Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik, Richie R. Bhandare, Srinath Nissankararao, Zehra Edis, N. Ravikiran Tangirala, Shaik Shahanaaz, M. Mukhlesur Rahman   +6 more
doaj   +1 more source