Results 21 to 30 of about 49,938 (301)
Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine [PDF]
Journal of the Serbian Chemical Society, 2012 A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized.
Sharma Ritu +3 more
doaj +1 more source
Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts
Medicines, 2022 Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative ...
Kojo Sekyi Acquah +6 more
doaj +1 more source
Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles
ACS Biomaterials Science & Engineering, 2021 Pretomanid and MCC7433, a novel nitroimidazopyrazinone analog, are promising antitubercular agents that belong to the bicyclic nitroimidazole family.
C. W. Ang +6 more
semanticscholar +1 more source
Antitubercular pharmacodynamics of phenothiazines [PDF]
Journal of Antimicrobial Chemotherapy, 2012 Phenothiazines have been shown to exhibit in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb) and multidrug-resistant Mtb. They are predicted to target the genetically validated respiratory chain component type II NADH:quinone oxidoreductase (Ndh).
Neil G. Berry +7 more
openaire +3 more sources
Pharmaceutics, 2022 The scarcity of age-appropriate pharmaceutical formulations is one of the major challenges impeding successful management of tuberculosis (TB) prevalence in minors.
Penelope N. Rampedi +3 more
doaj +1 more source
Molecules, 2021 Compounds bearing thiazole and chalcone pharmacophores have been reported to possess excellent antitubercular and anticancer activities. In view of this, we designed, synthesized and characterized a novel series of thiazole–chalcone hybrids (1–20) and ...
Ashok Babu Kasetti +4 more
semanticscholar +1 more source
Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]
, 2020 Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca +6 more
core +1 more source
Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents
Pharmaceuticals, 2020 This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina +3 more
doaj +1 more source
Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report [PDF]
Annals of Coloproctology, 2021 Paradoxical reactions to tuberculosis (TB) treatment are characterized by an initial improvement of the clinical symptoms followed by clinical or radiological deterioration of existing tuberculous lesions, or by development of new lesions.
Sung Hoon Kang +10 more
doaj +1 more source
Pharmaceuticals, 2021 Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established ...
M. Mori +8 more
semanticscholar +1 more source