Results 41 to 50 of about 35,652 (265)
Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3
Applied Sciences, 2020 The development and spread of Mycobacterium tuberculosis multi-drug resistant strains still represent a great global health threat, leading to an urgent need for novel anti-tuberculosis drugs.
G. Degiacomi +5 more
semanticscholar +1 more source
Molecules, 2012 A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei +8 more
doaj +1 more source
Novel Pyrimidines as Antitubercular Agents [PDF]
Antimicrobial Agents and Chemotherapy, 2018 ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Srinivasan Kandasamy +13 more
openaire +3 more sources
Molecules, 2015 A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H2SO4. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7 ...
Dong Cai +6 more
doaj +1 more source
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility
Journal of Medicinal Chemistry, 2020 Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases.
C. W. Ang +9 more
semanticscholar +1 more source
Microbial glycosylation of antitubercular agent chlorflavonin [PDF]
Journal of Bioscience and Bioengineering, 2023 Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire +3 more sources
Antioxidant, Antitubercular and Cytotoxic Activities of Piper imperiale
Molecules, 2012 Phenolic compounds are widely distributed in Nature and act as pharmacologically active constituents in many herbal medicines. They have multiple biological properties, most notably antioxidant, antibacterial and cytotoxic activities.
Sanjib Bhakta +6 more
doaj +1 more source
Cutaneous drug reaction secondary to antitubercular regimen: A case report from Nepal
SAGE Open Medical Case Reports, 2023 Cutaneous adverse drug reactions are known side effects of first-line antitubercular therapy, which ranges from mild pruritus to life-threatening toxic epidermal necrolysis.
Himal Bikram Bhattarai +9 more
doaj +1 more source
Frontiers in Immunology, 2018 Mycobacterium tuberculosis (M. tb), the causative bacterial agent responsible for tuberculosis (TB) continues to afflict millions of people worldwide. Although the human immune system plays a critical role in containing M.
Garrett Teskey +14 more
doaj +1 more source
Synergistic Lethality of a Binary Inhibitor of
mBio, 2018 We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target.
Pradeep Kumar +32 more
doaj +1 more source