Results 51 to 60 of about 50,974 (272)

Cutaneous drug reaction secondary to antitubercular regimen: A case report from Nepal

SAGE Open Medical Case Reports, 2023
Cutaneous adverse drug reactions are known side effects of first-line antitubercular therapy, which ranges from mild pruritus to life-threatening toxic epidermal necrolysis.
Himal Bikram Bhattarai, Jeshika Yadav, Sangrila Sapkota, Adarsha Adhikari, Madhur Bhattarai, Ishani Singh, Sujan Shrestha, Jwala KC, Prakash Karki, Bibhusan Basnet   +9 more
doaj   +1 more source

Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di-N-Oxides Containing an Amino Acidic Side Chain

Pharmaceuticals
We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity.
Juan F. González, María-Auxiliadora Dea-Ayuela, Lena Huck, José María Orduña, Francisco Bolás-Fernández, Elena de la Cuesta, Nazia Haseen, Ashraf Ali Mohammed, J. Carlos Menéndez   +8 more
doaj   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones

Molecules, 2017
Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory
Carlos R. Polaquini, Guilherme S. Torrezan, Vanessa R. Santos, Ana C. Nazaré, Débora L. Campos, Laíza A. Almeida, Isabel C. Silva, Henrique Ferreira, Fernando R. Pavan, Cristiane Duque, Luis O. Regasini   +10 more
doaj   +1 more source

Promising Lead Compounds in the Development of Potential Clinical Drug Candidate for Drug-Resistant Tuberculosis

Molecules, 2020
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen,
Saad Alghamdi, Shaheed Ur Rehman, Nashwa Talaat Shesha, Hani Faidah, Muhammad Khurram, Sabi Ur Rehman   +5 more
doaj   +1 more source

Inhalable antitubercular therapy mediated by locust bean gum microparticles [PDF]

, 2016
Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of ...
Alves, Ana, Cavaco, Joana, Costa, Ana M. Rosa da, Grenha, Ana, Guerreiro, Filipa, Lourenço, J. P.   +5 more
core   +2 more sources

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, EarlyView.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Bridged [2.2.1] bicyclic phosphine oxide facilitates catalytic γ-umpolung addition-Wittig olefination. [PDF]

, 2018
A novel bridged [2.2.1] bicyclic phosphine oxide, devised to circumvent the waste generation and burdens of purification that are typical of reactions driven by the generation of phosphine oxides, has been prepared in three steps from commercially ...
Cai, Lingchao, Houk, KN, Kwon, Ohyun, Yang, Zhongyue, Zhang, Kui   +4 more
core   +1 more source

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Journal of Medicinal Chemistry, 2020
Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases.
C. W. Ang, Lendl Tan, M. Sykes, Neda AbuGharbiyeh, Anjan Debnath, J. C. Reid, N. West, V. Avery, M. Cooper, M. Blaskovich   +9 more
semanticscholar   +1 more source

Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus

Molecules, 2018
The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12-O-deacetyl-12,19-di-epi-scalarin (14), a new scalarane sesterterpenoid, along with fourteen previously-reported ...
Abdulrahman M. Alahdal, Hani Z. Asfour, Safwat A. Ahmed, Ahmad O. Noor, Ahmed M. Al-Abd, Mahmoud A. Elfaky, Sameh S. Elhady   +6 more
doaj   +1 more source