Results 51 to 60 of about 25,061 (213)

Triterpenes and antitubercular activity of Byrsonima crassa [PDF]

Química Nova, 2008
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone.
Higuchi, Célio Takashi, Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Sannomiya, Miriam, Vilegas, Wagner, Leite, Sergio Roberto de Andrade, Sacramento, Luis Vitor S., Sato, Daisy Nakamura   +7 more
openaire   +6 more sources

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies

Molecules, 2020
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains one of the top ten causes of death worldwide and the main cause of mortality from a single infectious agent.
Cátia Teixeira, Cristina Ventura, José R. B. Gomes, Paula Gomes, Filomena Martins   +4 more
doaj   +1 more source

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda, Daria Nawrot, Petr Šlechta, Miroslav Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

A Randomized Double‐Blind, Placebo‐Controlled Trial of Artesunate and Curcumin in Patients With Crohn's Disease: A Pilot Study

JGH Open, Volume 9, Issue 7, July 2025.
ABSTRACT Aim Less than half of all patients with Crohn's disease remain in remission with long‐term use of azathioprine. Our aim was to assess the efficacy of Artesunate and Curcumin in maintaining remission in patients with Crohn's disease, who had ongoing evidence of disease activity despite taking azathioprine.
Devinder Kumar, Uday C Ghoshal, Vamika Mansi Saigal, Moni Chaudhary, Shikha Sahu, Vishruti Pandya, Ujjala Ghoshal   +6 more
wiley   +1 more source

Paradoxical Worsening of Tubercular Serpiginous-Like Choroiditis after Initiation of Antitubercular Therapy

Türk Oftalmoloji Dergisi, 2016
In this study, a case with tubercular choroiditis showing severe macular edema and progression of choroidal lesions following initiation of antitubercular treatment is presented and the management of posterior uveitis associated with tuberculosis is ...
Ebru Esen, Selçuk Sızmaz, Zeynep Kunt, Nihal Demircan   +3 more
doaj   +1 more source

Chylothorax in Uncommon Contexts: Pulmonary Tuberculosis and Mantle Cell Lymphoma

Respirology Case Reports, Volume 13, Issue 7, July 2025.
We present a series of three cases, which emphasises the diverse causes and treatment of chylothorax. ABSTRACT Chylothorax, characterised by the accumulation of chyle in the pleural space, is a rare yet clinically significant condition. This lymphatic fluid, rich in fats absorbed from the intestine, can be caused by various factors including trauma ...
Guru Prasad T J, Athish Kannan Karur, Spurthy Padmanabha, K. R. Harshitha, Suggula Vamsi Krishna, Rashmi Priya Murthy, Samuel Olaniyan, Adewale Oyeneye, Anwadevi Arun, Franklin John   +9 more
wiley   +1 more source

Erythema nodosum and antitubercular therapy

Journal of Dermatological Treatment, 2004
To establish the efficacy of antitubercular therapy in patients with erythema nodosum with a highly positive Mantoux test.A retrospective analysis of all patients diagnosed with idiopathic erythema nodosum with a highly positive Mantoux reaction between 1988 and 2001 was undertaken.
Bhushan Kumar, Kamaldeep Sandhu
openaire   +2 more sources

Ionophoric effects of the antitubercular drug bedaquiline [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Antibiotics generally target one of five essential cellular functions in bacteria, but many of these targets are now compromised through rapidly spreading antibiotic resistance. Bedaquiline (BDQ), a new FDA-approved antitubercular drug, targets energy metabolism: defining cellular energetics as a new target space for
Holger Lill, Duncan G. G. McMillan, Gregory M. Cook, Gregory M. Cook, Lici A. Schurig-Briccio, Dirk Bald, Kiel Hards, Robert B. Gennis   +7 more
openaire   +6 more sources

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source