Results 61 to 70 of about 35,652 (265)

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

mLife, EarlyView.
Abstract The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research.
Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen   +12 more
wiley   +1 more source

Antitubercular Triazines: Optimization and Intrabacterial Metabolism [PDF]

Cell Chemical Biology, 2020
The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases in addition to Ddn.
Xin Wang, Daigo Inoyama, Riccardo Russo, Shao-Gang Li, Ravindra Jadhav, Thomas P. Stratton, Nisha Mittal, Joseph A. Bilotta, Eric Singleton, Thomas Kim, Steve D. Paget, Richard S. Pottorf, Yong-Mo Ahn, Alejandro Davila-Pagan, Srinivasan Kandasamy, Courtney Grady, Seema Hussain, Patricia Soteropoulos, Matthew D. Zimmerman, Hsin Pin Ho, Steven Park, Véronique Dartois, Sean Ekins, Nancy Connell, Pradeep Kumar, Joel S. Freundlich   +25 more
openaire   +2 more sources

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Quinoline: A promising antitubercular target

Biomedicine & Pharmacotherapy, 2014
Tuberculosis (TB) remains a global public health problem in recent years. TB originated mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic disease with high infection rate since ancient times. Since the last 50 years, the same long-duration, multidrug treatment plan is being followed for the treatment of ...
Rangappa S. Keri, Siddappa A. Patil
openaire   +3 more sources

Intracellular Penetration of Atazanavir, Ritonavir and Dolutegravir With Concomitant Rifampicin: A Dose Escalation Study

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1393-1402, May 2025.
Ritonavir‐boosted atazanavir is a victim of drug–drug interaction with rifampicin, a key component of antitubercular treatment. In a recent dose escalation clinical trial, we showed that increasing atazanavir/ritonavir to 300/100 mg b.i.d. compensates for reduced drug exposure in plasma due to rifampicin, but the intracellular effects remained ...
Amedeo De Nicolò, Alice Palermiti, Henry Mugerwa, Shamim Nakabuye, Josephine Namusanje, Josephine Kobusingye, Denis Odoch, Mohammed Lamorde, Allan Kengo, Paolo Denti, Kamunkhwala Gausi, Gary Maartens, Helen McIlleron, Lubbe Wiesner, Saye Khoo, Catriona Waitt, Antonio D'Avolio   +16 more
wiley   +1 more source

Triterpenes and antitubercular activity of Byrsonima crassa [PDF]

Química Nova, 2008
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone.
Higuchi, Célio Takashi, Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Sannomiya, Miriam, Vilegas, Wagner, Leite, Sergio Roberto de Andrade, Sacramento, Luis Vitor S., Sato, Daisy Nakamura   +7 more
openaire   +6 more sources

Paradoxical Worsening of Tubercular Serpiginous-Like Choroiditis after Initiation of Antitubercular Therapy

Türk Oftalmoloji Dergisi, 2016
In this study, a case with tubercular choroiditis showing severe macular edema and progression of choroidal lesions following initiation of antitubercular treatment is presented and the management of posterior uveitis associated with tuberculosis is ...
Ebru Esen, Selçuk Sızmaz, Zeynep Kunt, Nihal Demircan   +3 more
doaj   +1 more source

Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages

Advanced Therapeutics, Volume 8, Issue 4, April 2025.
Tackling the problem of tuberculosis (TB) and human immunodeficiency virus (HIV) co‐infection is a serious global health concern affecting people of all ages. This review presents the characteristics of both diseases, current treatment and diagnostic guidelines, associated problems, innovations in disease management, and overall effects on global ...
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
wiley   +1 more source

Clinical Features and Outcomes of Patients With Tubercular Uveitis Treated With Antitubercular Therapy in the Collaborative Ocular Tuberculosis Study (COTS)–1

JAMA ophthalmology, 2017
Importance Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence of systemic TB, the existing uncertainty in the diagnosis of TB ...
Rupesh V Agrawal, D. Gunasekeran, R. Grant, A. Agarwal, O. Kon, Q. Nguyen, C. Pavesio, Vishali Gupta   +7 more
semanticscholar   +1 more source

Erythema nodosum and antitubercular therapy

Journal of Dermatological Treatment, 2004
To establish the efficacy of antitubercular therapy in patients with erythema nodosum with a highly positive Mantoux test.A retrospective analysis of all patients diagnosed with idiopathic erythema nodosum with a highly positive Mantoux reaction between 1988 and 2001 was undertaken.
Bhushan Kumar, Kamaldeep Sandhu
openaire   +2 more sources