Results 61 to 70 of about 25,061 (213)
ChemistrySelect, Volume 10, Issue 25, July 4, 2025.Piperazine derivatives 2b, 2f, and 2h reduce neuroinflammation, oxidative stress, and memory impairment by modulating COX‐2, p‐NF‐κB, and TNF‐α pathways, showing promise as lead compounds for neurodegenerative disease drug development. Abstract Oxidative stress‐induced neuro‐inflammatory events are common in neurodegenerative illnesses, addressing ...
Sadaf Fardoos +8 more
wiley +1 more source
Antitubercular activity of trifluoperazine, a calmodulin antagonist [PDF]
FEMS Microbiology Letters, 1992 Trifluoperazine, a calmodulin antagonist, completely inhibited the growth of mycobacteria. The minimum inhibitory concentrations in shake cultures in a synthetic medium containing 0.2% Tween 80 were 5 and 8 micrograms/ml, respectively, for the human pathogenic strain Mycobacterium tuberculosis H37Rv and M. tuberculosis resistant to isoniazid.
P. Ratnakar, P. Suryanarayana Murthy
openaire +3 more sources
Frontiers in Pharmacology, 2018 Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of drug resistant strains. Antitubercular peptides may provide an alternate approach to combat antibiotic tolerance.
Salman Sadullah Usmani +4 more
doaj +1 more source
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar +10 more
wiley +1 more source
PYRAZINAMIDE INDUCED ACUTE GOUTY ARTHRITIS
Journal of Nepal Medical Association, 2003 A typical case of pyrazinamide induced acute gouty arthritis in a tuberculous patient with antitubercular therapy including pyrazinamide was reported.
U N Pathak, B O Shrestha, R R Shrestha
doaj +1 more source
Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential
ChemBioEng Reviews, Volume 12, Issue 3, June 2025.This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona +2 more
wiley +1 more source
Atypical clinical and imaging manifestation in neurocysticercosis
Annals of Indian Academy of Neurology, 2011 A 20-year-old man presented with left-sided headache and seizures of three years duration. Conglomerate ring-enhancing lesions were seen in the first magnetic resonance imaging study. He was initially treated with anticonvulsants for two years.
L Dayananda +4 more
doaj +1 more source
Novel Metronidazole Conjugates as Antimicrobial Agents
Drug Development Research, Volume 86, Issue 4, June 2025.ABSTRACT Metronidazole (MTZ) is one of the oldest and still used anti‐infective nitroimidazole group drug. Although it is effective against anaerobic bacteria, protozoa, and parasites in clinical settings, it lacks efficacy against aerobic microorganisms.
Erol Akgün +4 more
wiley +1 more source
TOWARDS NEW ANTITUBERCULAR DRUGS
Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze, 2015 Tuberculosis, with million new cases every year, still represents a worldwide health threat. This infectious disease is caused by Mycobacterium tuberculosis and affects primarily the lungs, although it can spread to other organs. The peculiar mycobacterial cell wall makes these bacteria resistant to most of the antibiotics and for this reason the first-
Binda, Claudia +3 more
openaire +2 more sources
Multiple Bilateral Erythematous and Suppurative Cutaneous Nodules in a 40‐Year‐Old Indian Female
JEADV Clinical Practice, EarlyView.
Aditi Anand +2 more
wiley +1 more source