Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
ChemistrySelect, Volume 11, Issue 3, 22 January 2026.Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala +5 more
wiley +1 more source
Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]
, 2019 The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde +1 more
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International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.Objective To evaluate the therapeutic efficacy and safety of pyrazinamide compared with pasiniazid in elderly patients with pulmonary tuberculosis (PTB) and to investigate their effects on serum inflammatory markers, including interferon‐gamma (IFN‐γ) and tumor necrosis factor‐alpha (TNF‐α).
Juan Liu +5 more
wiley +1 more source
Quality of the life of the TB patients
Кубанский научный медицинский вестник, 2015 In the article the results of studying the quality of the life of patients with tuberculosis are represented. By the authors were interviewed 500 patients GBUz SK «Boundary antitubercular dispensary» (g. Stavropol').
V. B. Zafirova +3 more
doaj
Frontiers in Pharmacology, 2018 Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of drug resistant strains. Antitubercular peptides may provide an alternate approach to combat antibiotic tolerance.
Salman Sadullah Usmani +4 more
doaj +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, Volume 90, Issue 12, December 10, 2025.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
(E)-N'-(2, 4-dihydroxybenzylidene)nicotinohydrazide and its Metal Complexes: Synthesis, Characterisation and Antitubercular Activity [PDF]
, 2016 Nicotinic acid hydrazide and 2,4-dihydoxylbenzaldehyde were condensed at 20 °C to form an acylhydrazone (H3L1) with ONO coordination pattern. The structure of the acylhydrazone was elucidated by using CHN analyzer, ESI mass spectrometry, IR, 1H NMR, 13C ...
Adekoya, J. A.
core
Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance. [PDF]
, 2015 In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4 ...
Cabrera, JL +12 more
core +3 more sources
Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era [PDF]
, 2021 Alina Minias +7 more
openalex +1 more source