Results 1 to 10 of about 15,994 (195)

Discovery of dipiperidines as new antitubercular agents [PDF]

Bioorganic & Medicinal Chemistry Letters, 2009
As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for activity against Mycobacteriumtuberculosis. Structure-activity relationship (SAR) evaluation identified
Elena Bogatcheva, Colleen F. Hanrahan, Ping Chen, Jacqueline Gearhart, Katherine A. Sacksteder, Leo Einck, Carol A. Nacy, Marina Protopopova   +7 more
openalex   +4 more sources

Culture conversion at six months in patients receiving bedaquiline- and delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

International Journal of Infectious Diseases, 2021
Rifampicin-resistant/multidrug-resistant (RR/MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis (TB) are serious public health problem in Kazakhstan.
Shynar M. Maretbayeva, Anar S. Rakisheva, Malik M. Adenov, Lyazzat T. Yeraliyeva, Yerkebulan Zh. Algozhin, Assel T. Stambekova, Elmira A. Berikova, Askar Yedilbayev, Michael L. Rich, Kwonjune J. Seung, Assiya M. Issayeva   +10 more
doaj  

Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents [PDF]

, 2010
Kunal Kumar, Divya Awasthi, Seung-Yub Lee, Ilaria Zanardi, Bela Ruzsicska, Susan E. Knudson, Peter J. Tonge, Richard A. Slayden, Iwao Ojima   +8 more
openalex   +1 more source

Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent d -Cycloserine Produced by Streptomyces lavendulae [PDF]

, 2010
Takanori Kumagai, Yusuke Koyama, Kosuke Oda, Masafumi Noda, Yasuyuki Matoba, Masanori Sugiyama   +5 more
openalex   +1 more source

Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents. [PDF]

Eur J Med Chem, 2023
Wen Y, Lun S, Jiao Y, Zhang W, Liu T, Yang F, Tang J, Bishai WR, Yu LF.   +8 more
europepmc   +1 more source

Antitubercular Agents: Quantitative Structure Activity Relationships and Drug Design [PDF]

, 2012
Mushtaque S. Shaikh, Vijay M. Khedkar, Evans C. Coutinho   +2 more
openalex   +1 more source

Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents. [PDF]

Mol Divers, 2023
Jesumoroti OJ, Beteck RM, Jordaan A, Warner DF, Legoabe LJ.   +4 more
europepmc   +1 more source

Multidrug-resistant tuberculosis

Revista Ciencias Biomédicas, 2013
Introduction: tuberculosis is an increasing problem of global health and the microbialdrug resistance a generating element of worry.Clinical case: 19 year-old patient, who admitted to the emergency room for presentinghemoptysis and who had history of ...
Álvarez-Gaviria Manuel, De-la-Vega Fernando, Bello-Espinosa Ariel, Lora-Hurtado Merle, Navas-Torrejano Diana, Herazo-Bustos Cherina   +5 more
doaj  

Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents [PDF]

, 2013
Namrata Anand, K. Kumar G. Ramakrishna, Munna Prasad Gupt, Vinita Chaturvedi, Shubhra Singh, Kishore K. Srivastava, Prapunjika Sharma, Niyati Rai, Ravishankar Ramachandran, Anil Kumar Dwivedi, Varsha Gupta, Brijesh Kumar, Smriti Pandey, Praveen Kumar Shukla, Shailandra K. Pandey, Jawahar Lal, Rama P. Tripathi   +16 more
openalex   +1 more source

Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents. [PDF]

ACS Bio Med Chem Au, 2023
Konas DW, Cho S, Thomas OD, Bhatti MM, Leon Hernandez K, Moran C, Booter H, Candela T, Lacap J, McFadden P, van den Berg S, Welter AM, Peralta A, Janson CA, Catalano J, Goodey NM.   +15 more
europepmc   +1 more source