Studies on new substituted pyridazinones: synthesis and biological evaluation [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2018 We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif +3 more
doaj +3 more sources
Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities [PDF]
Molecules, 2020 Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally.
Afzal B. Shaik +6 more
doaj +3 more sources
Development of Pseudomembranous Colitis Four Months after Initiation of Rifampicin [PDF]
Case Reports in Gastroenterology, 2011 Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin.
Jeong Moon Choi +4 more
doaj +4 more sources
Causality assessment, severity and preventability of adverse drug reactions due to first-line antitubercular agents [PDF]
Pharmaciana, 2022 TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions is one of the major concerns for the management of TB.
Gunjan Upadhyay +2 more
doaj +1 more source
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]
, 2013 Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
A Alahari +44 more
core +6 more sources
Inhalable spray-dried chondroitin sulphate microparticles: effect of different solvents on particle properties and drug activity [PDF]
, 2020 Spray-drying stands as one of the most used techniques to produce inhalable microparticles, but several parameters from both the process and the used materials affect the properties of the resulting microparticles.
Buttini, Francesca +6 more
core +1 more source
Tricyanated Ferrocenes; Isolation, structure, electrochemistry and DFT calculations
Zeitschrift für anorganische und allgemeine Chemie, Volume 649, Issue 1, January 2, 2023., 2023 Abstract 1,2,3‐ Tricyanoferrocene and 1,3‐dibromo‐2,4,5‐tricyanoferrocene have been synthesized via metallation and usage of dimethylmalononitrile (DMMN) as cyanating agent. They are the first compounds where three nitrile functions could be introduced into the ferrocene sceleton.
Tobias Blockhaus +4 more
wiley +1 more source
Journal of Nepal Medical Association, 2021 Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs ...
Naveen Prakash Shah +5 more
doaj +1 more source
Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies [PDF]
, 2022 A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Bhandare, R. R. +15 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source