Results 1 to 10 of about 23,589 (259)

Exploration of Piperidinols as Potential Antitubercular Agents [PDF]

Molecules, 2014
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J. Russell, Garrett M. Morris, Paul W. Finn, Edith Sim   +6 more
doaj   +8 more sources

Design and synthesis of 3-(4-aminophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide/carbothioamide analogues as antitubercular agents

Beni-Suef University Journal of Basic and Applied Sciences, 2015
Emergence of multi-drug resistant tuberculosis (MDR-TB) and HIV-TB co-infections potentiate the development of newer antitubercular agents to combat against tuberculosis, a dreadful disease.
Mohamed Jawed Ahsan, Veerendra Saini
doaj   +2 more sources

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents [PDF]

Pharmaceuticals, 2021
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established ...
Matteo Mori, Giovanni Stelitano, Laurent R. Chiarelli, Giulia Cazzaniga, Arianna Gelain, Daniela Barlocco, Elena Pini, Fiorella Meneghetti, Stefania Villa   +8 more
doaj   +2 more sources

Novel Pyrimidines as Antitubercular Agents. [PDF]

Antimicrob Agents Chemother, 2018
ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Inoyama D, Paget SD, Russo R, Kandasamy S, Kumar P, Singleton E, Occi J, Tuckman M, Zimmerman MD, Ho HP, Perryman AL, Dartois V, Connell N, Freundlich JS.   +13 more
europepmc   +4 more sources

Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents [PDF]

Data in Brief, 2017
Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out.
Amit S. Tapkir, Sohan S. Chitlange, Ritesh P. Bhole   +2 more
doaj   +2 more sources

Papulonecrotic tuberculid caused by Bacille Calmette-Guerin vaccination requiring no antitubercular agents. [PDF]

IDCases, 2021
Araki K, Inamine I, Aoki T, Magota M.
europepmc   +2 more sources

Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents. [PDF]

RSC Med Chem, 2021
Haranahalli K, Tong S, Kim S, Awwa M, Chen L, Knudson SE, Slayden RA, Singleton E, Russo R, Connell N, Ojima I.   +10 more
europepmc   +3 more sources

Structure-Activity Relationships of Pyrazolo[1,5-<i>a</i>]pyrimidin-7(4<i>H</i>)-ones as Antitubercular Agents. [PDF]

ACS Infect Dis, 2021
Oh S, Libardo MDJ, Azeeza S, Pauly GT, Roma JSO, Sajid A, Tateishi Y, Duncombe C, Goodwin M, Ioerger TR, Wyatt PG, Ray PC, Gray DW, Boshoff HIM, Barry CE.   +14 more
europepmc   +3 more sources

Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents [PDF]

International Journal of Nanomedicine, 2016
Richa Singh,1 Laxman Nawale,2 Manisha Arkile,2 Sweety Wadhwani,1 Utkarsha Shedbalkar,1 Snehal Chopade,1 Dhiman Sarkar,2 Balu Ananda Chopade1,3 1Department of Microbiology, Savitribai Phule Pune University, 2Combichem-Bioresource Center, Organic ...
Singh R, Nawale L, Arkile M, Wadhwani S, Shedbalkar U, Chopade S, Sarkar D, Chopade BA   +7 more
doaj   +2 more sources

Identification of benzothiazones containing a hexahydropyrrolo[3,4-c]pyrrol moiety as antitubercular agents against MDR-MTB. [PDF]

RSC Adv, 2020
Ma X, Han B, Wang A, Yang L, Huang M, Chowdhury K, Gu J, Zhang K, Lv K.   +8 more
europepmc   +3 more sources