Results 1 to 10 of about 3,165,159 (259)
Novel Pyrimidines as Antitubercular Agents [PDF]
Antimicrobial Agents and Chemotherapy, 2018 Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics.
Daigo Inoyama +13 more
semanticscholar +5 more sources
Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents [PDF]
International Journal of Nanomedicine, 2016 Multi- and extensively drug-resistant tuberculosis (TB) is a global threat to human health. It requires immediate action to seek new antitubercular compounds and devise alternate strategies. Nanomaterials, in the present scenario, have opened new avenues in medicine, diagnosis, and therapeutics.
Balu A. Chopade +7 more
europepmc +8 more sources
Discovery of dipiperidines as new antitubercular agents [PDF]
Bioorganic & Medicinal Chemistry Letters, 2009 As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for activity against Mycobacteriumtuberculosis. Structure-activity relationship (SAR) evaluation identified
Elena Bogatcheva +7 more
openalex +4 more sources
Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents. [PDF]
ACS Med Chem Lett, 2022 The 6-trifluoro substituted 8-nitrobenzothiazinones (BTZs) represent a novel type of antitubercular agents, and their high antimycobacterial activity is related to the inhibition of decaprenylphosphoryl-β-d-ribose 2'-oxidase (DprE1), an enzyme essential ...
Rui Shi +9 more
semanticscholar +2 more sources
New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling [PDF]
Pharmaceuticals (Basel), 2022 A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step.
Rashmika Moodley +9 more
semanticscholar +2 more sources
Synthesis of functionalized sulfonamides as antitubercular agents
Phosphorus, Sulfur, and Silicon and the Related Elements, 2023 Using up-to-date methods for synthesis and analysis, 51 sulfonamides were prepared for use as tools in antitubercular drug discovery. The synthetic efforts were centered on varying substituents at three key structural units implicated in antimicrobial activity, namely the sulfonyl group, nitrogen N1 and nitrogen N4.
Michael J. Hearn +2 more
openalex +3 more sources
Second-line antitubercular agents and their adverse effects
Vojnosanitetski pregled, 2006 Uprkos cinjenici da su lekovi protiv tuberkuloze otkriveni pre vise od 50 godina i da je tuberkuloza izleciva bolest, ona i danas predstavlja veliki zdravstveni i socijalni problem kako u zemljama u razvoju, tako i u visokorazvijenim zemljama. Prema podacima Svetske zdravstvene organizacije (SZO) u svetu se godisnje registruje 8−10 miliona novoobolelih,
Vesna Škodrić-Trifunović +1 more
openalex +6 more sources
Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug- Resistant Tuberculosis
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016 The developing countries are having an abruptly growing number of drug resistant tuberculosis cases. Multidrug-resistant tuberculosis (MDR-TB) is a type of TB in which the strain of Mycobacterium tuberculosis is resistant to at least Isoniazid and Rifampicin, the two most effective of the four first-line TB drugs (the other two drugs being Ethambutol ...
Sankalp Yadav, Gautam Rawal, Mudit Baxi
openalex +4 more sources
Microbial glycosylation of antitubercular agent chlorflavonin [PDF]
Journal of Bioscience and Bioengineering, 2023 Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire +3 more sources
Improved Synthesis of the Antitubercular Agent SQ109 [PDF]
SynOpen, 2021 AbstractWe present here an improved procedure for the preparation of the promising antitubercular drug SQ109 that is currently in phase Ib/III of clinical trials against Mycobacterium tuberculosis. We investigated and tested the literature synthetic procedure that enables the development of structure–activity relationships and report the observed ...
Antonios Kolocouris, Marianna Stampolaki
openaire +2 more sources