Results 1 to 10 of about 3,270,661 (190)

QSAR modeling, molecular docking, dynamic simulation and ADMET study of novel tetrahydronaphthalene derivatives as potent antitubercular agents [PDF]

Beni-Suef University Journal of Basic and Applied Sciences, 2023
Tuberculosis is an air-borne contagious disease caused by slow-growing Mycobacterium tuberculosis (Mtb). According to Global Tuberculosis Report 2022, 1.6 million people were infected by tuberculosis in 2021.
Anguraj Moulishankar, T. Sundarrajan
semanticscholar   +2 more sources

Design and synthesis of 3-(4-aminophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide/carbothioamide analogues as antitubercular agents

Beni-Suef University Journal of Basic and Applied Sciences, 2015
Emergence of multi-drug resistant tuberculosis (MDR-TB) and HIV-TB co-infections potentiate the development of newer antitubercular agents to combat against tuberculosis, a dreadful disease.
Mohamed Jawed Ahsan, Veerendra Saini
doaj   +2 more sources

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

Pharmaceuticals, 2021
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established ...
Matteo Mori, Giovanni Stelitano, Laurent R. Chiarelli, Giulia Cazzaniga, Arianna Gelain, Daniela Barlocco, Elena Pini, Fiorella Meneghetti, Stefania Villa   +8 more
doaj   +2 more sources

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents [PDF]

ACS Infectious Diseases, 2021
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of ...
Sangmi Oh, M. D. Libardo, Shaik Azeeza, G. Pauly, J. S. Roma, Andaleeb Sajid, Yoshitaka Tateishi, C. Duncombe, Michael B. Goodwin, T. Ioerger, P. Wyatt, Peter C. Ray, David W. Gray, H. Boshoff, C. Barry   +14 more
semanticscholar   +2 more sources

Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents.

RSC Medicinal Chemistry, 2020
Filamenting temperature sensitive protein Z (FtsZ) is an essential bacterial cell division protein and a promising target for the development of new antibacterial therapeutics.
Krupanandan Haranahalli, Simon Tong, Saerom Kim, Monaf Awwa, Lei Chen, Susan E. Knudson, R. Slayden, E. Singleton, Riccardo Russo, N. Connell, I. Ojima   +10 more
semanticscholar   +3 more sources

Exploration of Piperidinols as Potential Antitubercular Agents [PDF]

Molecules, 2014
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J. Russell, Garrett M. Morris, Paul W. Finn, Edith Sim   +6 more
doaj   +6 more sources

Synthesis of fluoro-rich pyrimidine-5-carbonitriles as antitubercular agents against H37Rv receptor

Heterocyclic Communications, 2022
The purpose of this study was to prepare various derivatives of 4-amino-2-(3-fluoro-5-(trifluoromethyl)phenyl)-6-arylpyrimidine-5-carbonitrile (6a–6h) using a three-step procedure. The derivatives were screened in vitro for activity against Mycobacterium
Kapadiya Khushal M., Kavadia Kishor M., Khedkar Vijay M., Dholaria Piyush V., Jivani Amita J., Khunt Ranjan C.   +5 more
doaj   +2 more sources

Synthesis and biological evaluation of some 4-aminoquinoline derivatives as potential antitubercular agents [PDF]

Future Journal of Pharmaceutical Sciences, 2020
Based on bioisosteric similarities with thiacetazone, a series of 7-chloro-4-aminoquinoline derivatives have been designed and synthesized. The target compounds were elucidated by NMR, mass, and FTIR spectral data.
Shankar G. Alegaon, Kamlesh Kashniyal, Sanket Kuncolienkar, R. Kavalapure, P. Salve, M. Palled, S. Suryawanshi, S. Jalalpure   +7 more
semanticscholar   +2 more sources

Computational and Photophysical Probing Interactions of Newly Synthesized Benzothiazole Azo-Bonded Molecules Acting as Potent Antitubercular Agents

Journal of Molecular Structure, 2023
Chethana B. Krishnamurthy, J. Keshavayya, Chinnaraj Yesudhasan, A. Siva   +3 more
semanticscholar   +2 more sources

New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies [PDF]

Molecules, 2020
A series of 1,2,4-triazole derivatives were synthesized and assigned as potential anti-tuberculosis substances. The molecular and crystal structures for the model compounds C1, C12, and C13 were determined using X-ray analysis.
Z. Karczmarzyk, Marta Swatko-Ossor, W. Wysocki, M. Drózd, G. Ginalska, A. Pachuta-Stec, M. Pitucha   +6 more
semanticscholar   +2 more sources