Results 131 to 140 of about 3,270,661 (190)

Development and Evaluation of Bis-benzothiazoles as a New Class of Benzothiazoles Targeting DprE1 as Antitubercular Agents.

ACS Infectious Diseases
Benzothiazole-bearing compounds have emerged as potential noncovalent DprE1 (decaprenylphosphoryl-β-d-ribose-2'-epimerase) inhibitors active against Mycobacterium tuberculosis.
Rabiya Samoon, Shashikanta Sau, Arnab Roy, Kishan Kumar Parida, Kalicharan Sharma, P. A. Yakkala, R. P. Dewangan, Malik Zainul Abdin, N. P. Kalia, Syed Shafi   +9 more
semanticscholar   +1 more source

Thiophene containing triarylmethanes as antitubercular agents

Bioorganic & Medicinal Chemistry Letters, 2008
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.
Maloy Kumar, Parai, Gautam, Panda, Vinita, Chaturvedi, Y K, Manju, Sudhir, Sinha   +4 more
openaire   +2 more sources

Pyrazole-coumarin and pyrazole-quinoline chalcones as potential antitubercular agents.

Archiv der Pharmazie, 2020
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole-coumarin chalcones and pyrazole-quinoline chalcones were synthesized using multiple-step reactions.
Gautam Kumar, Vagolu Siva Krishna, D. Sriram, S. Jachak   +3 more
semanticscholar   +1 more source

[Antitubercular agents].

Minerva medica, 1984
Author resume the most important stages of the antitubercular struggle. Then they consider the action mechanisms of single drugs, often not well known, such the action mechanism of pyrazinamide. At present, the criteria of effectiveness, tolerance, availability and economy allow to use rationally and not arbitrarily the antitubercular drugs and these ...
M, Eandi, M, Buraglio
openaire   +1 more source

Synthesis, In-Silico and biological studies of thiazolyl-2h-chromen-2-one derivatives as potent antitubercular agents.

Current Computer - Aided Drug Design, 2020
BACKGROUND A series of new six thiazolyl-2-amine based Schiff base derivatives (4a-4f) were synthesized by a sequential multistep reactions starting with Salicylaldehyde.
Bhagwat Jadhav, R. Yamgar, R. Kenny, Suraj N. Mali, H. K. Chaudhari, Mustapha Mandewale   +5 more
semanticscholar   +1 more source

New Hydroxamic Acids as Antitubercular Agents

Nature, 1952
PREVIOUSLY, one of us suggested using salicylhydroxamic acid as an antitubercular agent1. The substance was subjected to clinical examination by another of us (S.H.) and showed promising results in fifteen cases of pulmonary tuberculosis. The substance was well tolerated by the patients, when large doses of 10–20 gm./day were administered.
T, URBANSKI, S, HORNUNG, S, SLOPEK, J, VENULET   +3 more
openaire   +2 more sources

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

Drug development research (Print), 2020
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug‐resistant tuberculosis
Mi Yan, Linlin Xu, Yinhu Wang, Jianhua Wan, Ting Liu, Wenjie Liu, Yichao Wan, Bin Zhang, Rongmei Wang, Qiang Li   +9 more
semanticscholar   +1 more source

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Future Medicinal Chemistry, 2019
AIM In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis.
Vitthal B. Makane, V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Chopra, D. Sriram, Vijayan N Azger Dusthackeer, H. Rode   +9 more
semanticscholar   +1 more source

Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents.

Journal of Natural Products, 2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities
P. Bangalore, S. K. Vagolu, R. K. Bollikanda, Dileep K. Veeragoni, P. Choudante, S. Misra, D. Sriram, B. Sridhar, S. Kantevari   +8 more
semanticscholar   +1 more source

Synthesis, structural, biological andin silicostudies of new 5-arylidene-4-thiazolidinone derivatives as possible anticancer, antimicrobial and antitubercular agents

New Journal of Chemistry, 2019
Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.
A. Sunil Kumar, Jyothi Kudva, B. Bharath, K. Ananda, Rajitha Sadashiva, S. Madan Kumar, B. Revanasiddappa, Vasantha Kumar, P. Rekha, Damodara Naral   +9 more
semanticscholar   +1 more source