Results 161 to 170 of about 16,306 (216)

Insightful chemistry of molecular docking studies and ADMET profiling of 4-amino-1,2,4-triazole scaffolds as potential inhibitor of DprE1 enzymes as antitubercular agents

Santosh Prasad Chaudhary Kurmi, Dipanjan Karati   +1 more
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Furan–thiazole hydrazone scaffolds as promising antitubercular and antibacterial agents: synthesis, characterization, bioevaluation and computational analysis

Yuvraj R. Sable, Rahul A. Shinde, Haya Yasin, Niraj Ghanwate, Suraj N. Mali, Suresh Ghotekar, Dhanesh P. Gawari, Dinesh A. Sasane, Vishnu A. Adole   +8 more
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Design, Synthesis, In Vitro Evaluation, Multitargeted Molecular Docking, and In Silico Analysis of Some Azo-Linked 1,3,4-Thiadiazole and 1,2,4-Triazole Heterocyclic Hybrids as Potent Antitubercular Agents

Debadash Panigrahi, Susanta Kumar Sahu
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5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent

Václav Pflégr, Jiřina Stolaříková, Galina Karabanovich, Jana Maixnerová, Adrian Pál, Jana Korduláková, Zuzana Šanderová, Michaela Liegertová, Jaroslav Roh, František Trejtnar, Jarmila Vinšová, Martin Krátký   +11 more
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Triazole: A Promising Antitubercular Agent

Chemical Biology & Drug Design, 2015
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Srinivasa Budagumpi, Siddappa A. Patil, Bhari Mallanna Nagaraja, Rangappa S. Keri   +3 more
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Thiophene containing triarylmethanes as antitubercular agents

Bioorganic & Medicinal Chemistry Letters, 2008
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.
Vinita Chaturvedi, Gautam Panda, Maloy Kumar Parai, Y.K. Manju, Sudhir Sinha   +4 more
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Synthesis and Investigation of Phthalazinones as Antitubercular Agents

Chemistry – An Asian Journal, 2019
AbstractA series of 2‐ and 7‐substituted phthalazinones was synthesised and their potential as anti‐tubercular drugs assessed via Mycobacterium tuberculosis (mc26230) growth inhibition assays. All phthalazinones tested showed growth inhibitory activity (MIC <100 μm), and those compounds containing lipophilic and electron‐withdrawing groups generally
Kristiana T. Santoso, Kristiana T. Santoso, Bridget L. Stocker, Bridget L. Stocker, Gregory M. Cook, Gregory M. Cook, Kiel Hards, Kiel Hards, Chen-Yi Cheung, Mattie S. M. Timmer, Mattie S. M. Timmer   +10 more
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New Hydroxamic Acids as Antitubercular Agents

Nature, 1952
PREVIOUSLY, one of us suggested using salicylhydroxamic acid as an antitubercular agent1. The substance was subjected to clinical examination by another of us (S.H.) and showed promising results in fifteen cases of pulmonary tuberculosis. The substance was well tolerated by the patients, when large doses of 10–20 gm./day were administered.
Venulet J, Urbanski T, Hornung S, Slopek S   +3 more
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Antitubercular Agents. Part 1. Synthesis of Phthalimido‐ and Naphthalimido‐Linked Phenazines as New Prototype Antitubercular Agents.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Rakesh Kumar Sinha, A. Venkata Ramana, Ahmed Kamal, Jhillu S. Yadav, Sudarshan K. Arora, A. Hari Babu   +5 more
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Salicylhydroxamic Acid as an Antitubercular Agent

Nature, 1950
SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous investigations seem to indicate that most of the antitubercular compounds contain amino-groups.
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