Results 1 to 10 of about 7,562 (136)

APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling [PDF]

Nature Communications
The APOBEC3 family of RNA and single stranded DNA cytidine deaminases contribute prominently to the mutagenesis of certain cancers including urothelial carcinoma of the bladder (UC).
Michael S. Sturdivant, Andrew S. Truong, Mi Zhou, Elliott D. Toomer, Wolfgang Beckabir, John Raupp, Ujjawal Manocha, Ibardo A. Zambrano, Hung-Jui Tan, Marc A. Bjurlin, Angela B. Smith, Tracy L. Rose, Matthew I. Milowsky, Sara E. Wobker, Kathryn H. Gessner, Jeffrey S. Damrauer, William Y. Kim   +16 more
doaj   +2 more sources

Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions [PDF]

Frontiers in Immunology
The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family was first defined as an innate antiviral defense system, but the APOBEC3 subfamily (APOBEC3s) is now recognized as a major endogenous source of somatic mutagenesis in cancer ...
Qiaoxi Li, Qiaoxi Li, Wenyu Wan, Wenyu Wan, Zihan Zhu, Zihan Zhu, Xuanduo Lin, Xuanduo Lin, Fei Wang, Fei Wang, Mengmeng Li, Mengmeng Li, Hao Guo, Hao Guo, Yang Yang, Yang Yang   +15 more
doaj   +2 more sources

MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing [PDF]

Journal of Virology
The 2022 outbreak of monkeypox virus (MPXV), a double-stranded DNA virus, is remarkable for an unusually high number of single-nucleotide substitutions compared to earlier strains, with a strong bias toward C→T and G→A transitions consistent with the ...
Alisa O. Lyskova, Ruslan Kh. Abasov, Anna Pavlova, Evgenii V. Matveev, Alexandra V. Madorskaya, Fedor M. Kazanov, Daria V. Garshina, Anna E. Smolnikova, Gennady V. Ponomarev, Elena I. Sharova, Dmitry N. Ivankov, Ogun Adebali, Mikhail S. Gelfand, Marat D. Kazanov   +13 more
doaj   +2 more sources

DHX15 inhibits mouse APOBEC3 deamination. [PDF]

PLoS Pathogens
APOBEC3 family proteins are critical host factors that counteract and prevent the replication of retroviruses and other viruses through cytidine deamination.
Wenming Zhao, Ayan Modak, Susan R Ross
doaj   +2 more sources

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model [PDF]

Frontiers in Genetics
IntroductionThe APOBEC3 family of cytidine deaminases induces somatic mutations that are highly prevalent in cancers, but the functional consequences remain largely unknown.MethodsTo determine these consequences, we exposed MCF7 tumorigenic breast ...
Milaid Granadillo Rodríguez, Lai Wong, Arzhang Shayeganmehr, Diogo Pellegrina, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Franco J. Vizeacoumar, Mohamed Helmy, Mohamed Helmy, Mohamed Helmy, Linda Chelico   +10 more
doaj   +2 more sources

Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]

, 2013
Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi, A Lassaux, A Reymond, AM Sheehy, AM Sheehy, B Jia, B Pacheco, B Song, BK Ganser-Pornillos, C Aberham, CA Virgen, CA Virgen, CH Liao, D Blanco-Melo, D Perez-Caballero, D Perez-Caballero, E Battivelli, EE Nakayama, F Zhang, F Zhang, G Brennan, GB Mortuza, GJ Towers, H Yang, HL Wiegand, Jeremy Luban, JW Bainbridge, K Hrecka, KR McCarthy, L Yin, M Pizzato, M Stremlau, M Stremlau, M Stremlau, M Stremlau, M Veillette, MJ Perron, MJ Perron, MR Auerbach, MW McNatt, MW Yap, MW Yap, N Van Damme, O Pornillos, Paul D. Bieniasz, R Mariani, RM Newman, S Cowan, S Ohkura, S Ohkura, S Sebastian, Sam J. Wilson, SB Kutluay, Sebla B. Kutluay, SJ Neil, SJ Rihn, SJ Wilson, SJ Wilson, SJ Wilson, SL Sawyer, Steven J. Soll, SY Lim, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, Theodora Hatziioannou, V Zennou, X Yu, Y Soneoka, YH Zheng, YJ Zhang, Z Ambrose, Z Keckesova, Z Kratovac   +75 more
core   +20 more sources

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead [PDF]

Open Biology, 2020
Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous
Milaid Granadillo Rodríguez, Ben Flath, Linda Chelico   +2 more
doaj   +1 more source

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells

Viruses, 2022
Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao, Masaaki Miyazawa   +8 more
doaj   +1 more source

B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells

Blood Cancer Journal, 2022
Constitutively activated B cell receptor (BCR) signaling is a primary biological feature of chronic lymphocytic leukemia (CLL). The biological events controlled by BCR signaling in CLL are not fully understood and need investigation. Here, by analysis of
Zhiquan Wang, Huihuang Yan, Justin C. Boysen, Charla R. Secreto, Renee C. Tschumper, Dania Ali, Qianqian Guo, Jian Zhong, Jiaqi Zhou, Haiyun Gan, Chuanhe Yu, Diane F. Jelinek, Susan L. Slager, Sameer A. Parikh, Esteban Braggio, Neil E. Kay   +15 more
doaj   +1 more source

APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types

BMC Biology, 2022
Background The APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide 3) family of cytidine deaminases is responsible for two mutational signatures (SBS2 and SBS13) found in cancer genomes.
G. Maria Jakobsdottir, Daniel S Brewer, Colin Cooper, Catherine Green, David C Wedge   +4 more
doaj   +1 more source