Results 11 to 20 of about 7,631 (195)
Mouse APOBEC3 Restriction of Retroviruses [PDF]
Viruses, 2020 Apolipoprotein B mRNA editing enzyme, catalytic peptide 3 (APOBEC3) proteins are critical host proteins that counteract and prevent the replication of retroviruses.
Karen Salas-Briceno +2 more
doaj +3 more sources
Insights into the motif preference of APOBEC3 enzymes. [PDF]
PLoS ONE, 2014 We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT.
Diako Ebrahimi +2 more
doaj +5 more sources
APOBEC3 Mediates Resistance to Oncolytic Viral Therapy [PDF]
Molecular Therapy: Oncolytics, 2018 Tumor cells frequently evade applied therapies through the accumulation of genomic mutations and rapid evolution. In the case of oncolytic virotherapy, understanding the mechanisms by which cancer cells develop resistance to infection and lysis is ...
Amanda L. Huff +14 more
doaj +5 more sources
APOBEC3 Interference during Replication of Viral Genomes [PDF]
Viruses, 2015 Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of
Luc Willems, Nicolas Albert Gillet
doaj +3 more sources
HIV restriction by APOBEC3 in humanized mice.
PLoS Pathogens, 2013 Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit.
John F Krisko +3 more
doaj +4 more sources
The coevolution between APOBEC3 and retrotransposons in primates
Mobile DNA, 2022 Retrotransposons are genetic elements with the ability to replicate in the genome using reverse transcriptase: they have been associated with the development of different biological structures, such as the Central Nervous System (CNS), and their high ...
Giorgia Modenini +2 more
doaj +4 more sources
Foamy Viruses, Bet, and APOBEC3 Restriction [PDF]
Viruses, 2021 Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are occasionally detected in bushmeat hunters or ...
Ananda Ayyappan Jaguva Vasudevan +4 more
openaire +4 more sources
Human APOBEC3 Variations and Viral Infection [PDF]
Viruses, 2021 Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes are capable of inhibiting a wide range of endogenous and exogenous viruses using deaminase and deaminase-independent mechanisms. These enzymes are essential components of our innate immune system, as evidenced by (a) their strong positive selection and expansion in ...
Shiva Sadeghpour +4 more
openaire +3 more sources
APOBEC3 Proteins in Viral Immunity [PDF]
The Journal of Immunology, 2015 Abstract Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Spyridon Stavrou, Susan R Ross
openaire +2 more sources
The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present
Viruses, 2021 The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Keiya Uriu +3 more
doaj +1 more source