Results 21 to 30 of about 7,631 (195)

APOBEC3s: DNA‐editing human cytidine deaminases [PDF]

Protein Science, 2019
AbstractNucleic acid editing enzymes are essential components of the human immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins. Among these enzymes are cytidine deaminases of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide‐like (APOBEC) super family, each with unique target sequence specificity and ...
Tania V. Silvas, Celia A. Schiffer
openaire   +3 more sources

Mice Deficient in APOBEC2 and APOBEC3 [PDF]

Molecular and Cellular Biology, 2005
The activation-induced deaminase/apolipoprotein B-editing catalytic subunit 1 (AID/APOBEC) family comprises four groups of proteins. Both AID, a lymphoid-specific DNA deaminase that triggers antibody diversification, and APOBEC2 (function unknown) are found in all vertebrates examined.
Marie C, Mikl, Ian N, Watt, Mason, Lu, Wolf, Reik, Sarah L, Davies, Michael S, Neuberger, Cristina, Rada   +6 more
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Biochemical and Biological Studies of Mouse APOBEC3 [PDF]

Journal of Virology, 2014
ABSTRACT Many murine leukemia viruses (MLVs) are partially resistant to restriction by mouse APOBEC3 (mA3) and essentially fully resistant to induction of G-to-A mutations by mA3. In contrast, Vif-deficient HIV-1 (ΔVif HIV-1) is profoundly restricted by mA3, and the restriction includes high levels of G-to-A mutation.
Smita, Nair, Silvia, Sanchez-Martinez, Xinhua, Ji, Alan, Rein   +3 more
openaire   +2 more sources

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

Retrovirology, 2017
Background APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a potent type I ...
Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo, Karl J. Heilman, Ross M. Kedl, Kim J. Hasenkrug, Mario L. Santiago   +7 more
doaj   +1 more source

Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation [PDF]

, 2006
APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G!92A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known.
Pace, C., Keller, J., Nolan, D., James, I., Gaudieri, S., Moore, C., Mallal, S.   +6 more
core   +2 more sources

APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition [PDF]

Journal of Biological Chemistry, 2006
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that has been shown to be active against a variety of retroviruses. Here we examined whether members of the APO-BEC3 family have an impact on retrotransposition of human long interspersed nuclear elements (LINE-1s or L1s).
Heide, Muckenfuss, Matthias, Hamdorf, Ulrike, Held, Mario, Perković, Johannes, Löwer, Klaus, Cichutek, Egbert, Flory, Gerald G, Schumann, Carsten, Münk   +8 more
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APOBEC3 mutagenesis drives therapy resistance in breast cancer. [PDF]

Nat Genet
Abstract Acquired genetic alterations drive resistance to endocrine and targeted therapies in metastatic breast cancer; however, the underlying processes engendering these alterations are largely uncharacterized.
Gupta A, Gazzo A, Selenica P, Safonov A, Pareja F, da Silva EM, Brown DN, Shao H, Zhu Y, Patel J, Blanco-Heredia J, Stefanovska B, Carpenter MA, Chen Y, Vegas I, Pei X, Frosina D, Jungbluth AA, Ladanyi M, Curigliano G, Weigelt B, Riaz N, Powell SN, Razavi P, Harris RS, Reis-Filho JS, Marra A, Chandarlapaty S.   +27 more
europepmc   +5 more sources

APOBEC3 enzymes restrict marginal zone B cells [PDF]

European Journal of Immunology, 2015
In general, a long‐lasting immune response to viruses is achieved when they are infectious and replication competent. In the mouse, the neutralizing antibody response to Friend murine leukemia virus is contributed by an allelic form of the enzyme Apobec3 (abbreviated A3). This is counterintuitive because A3 directly controls viremia before the onset of
Beck‐Engeser, Gabriele B, Winkelmann, Rebecca, Wheeler, Matthew L, Shansab, Maryam, Yu, Philipp, Wünsche, Sarah, Walchhütter, Anja, Metzner, Mirjam, Vettermann, Christian, Eilat, Dan, DeFranco, Anthony, Jäck, Hans‐Martin, Wabl, Matthias   +12 more
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Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis [PDF]

, 2017
The human genome displays a rich fossil record of past gamma-retrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells in vitro.
Ahmad, Shamim, Cameron, Ewan, Kilbey, Anna, Levy, Laura S., Mackay, Nancy, Naseer, Asif, Neil, James C., Terry, Anne, Watts, Ciorsdaidh, Wilson, Sam   +9 more
core   +1 more source

Restriction of MMTV by APOBEC3 [PDF]

Retrovirology, 2011
Background Host cells have developed a broad range of mechanisms to counteract retroviral infection. Besides Trim5a (tripartite motif-containing protein 5alpha) and Tetherin, APOBEC3 proteins (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3), especially APOBEC3G and APOBEC3F, are major factors in the post entry inhibition of ...
Kraase Martin, Konstantoulas Constantine, Indik Stanislav   +2 more
openaire   +2 more sources