Results 31 to 40 of about 7,631 (195)

APOBEC3 as a driver of genetic intratumor heterogeneity [PDF]

Molecular & Cellular Oncology, 2022
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F. Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton   +6 more
openaire   +4 more sources

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I

Viruses, 2023
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different efficiencies. The HIV-1 Vif protein combats APOBEC3-mediated restriction by inducing
Maria Yousefi, Arun Kumar Annan Sudarsan, Amit Gaba, Linda Chelico   +3 more
doaj   +1 more source

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer [PDF]

, 2016
BACKGROUND: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their ...
Bartek, J, Bartkova, J, Cerone, MA, Dietzen, M, Goh, G, Gromova, I, Harris, RS, Kanu, N, Kschischo, M, Law, EK, McGranahan, N, Rogers, R, Rossanese, OW, Swanton, C, Venkatesan, S, Walton, MI, Zalmas, L-P   +16 more
core   +8 more sources

APOBEC3 signature mutations in chronic lymphocytic leukemia [PDF]

Leukemia, 2014
Cytidine deaminases of the APOBEC family (ApoB mRNA editing catalytic subunit) generate targeted damage in nucleic acids by deaminating cytosins to uracils. The catalytically active family members are APOBEC1, APOBEC3 proteins (which comprise APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H) and activation-induced deaminase (AID ...
Rebhandl, S, Huemer, M, Gassner, F J, Zaborsky, N, Hebenstreit, D, Catakovic, K, Grössinger, E M, Greil, R, Geisberger, R   +8 more
openaire   +2 more sources

A novel role for APOBEC3: Susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice

Retrovirology, 2012
Background APOBEC3 proteins are host factors that restrict infection by retroviruses like HIV, MMTV, and MLV and are variably expressed in hematopoietic and non-hematopoietic cells, such as macrophages, lymphocytes, dendritic, and epithelia cells ...
Jones Philip H, Mehta Harshini V, Okeoma Chioma M   +2 more
doaj   +1 more source

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation [PDF]

, 2015
Macrophages are key targets of HIV-1 infection. We have previously described that the expressionof CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is furtherup-modulated by HIV-1 exposure.
Andreotti, Mauro, Bona, Roberta, Cara, Andrea, Covino, Daniela Angela, Covino, Daniela Angela, Fantuzzi, Laura, Federico, Maurizio, Gessani, Sandra, Lu, Jing, Mallano, Alessandra, Michelini, Zuleika, Pellegrini, Matteo, Purificato, Cristina, Rinaldi, Arturo Ottavio, Sabbatucci, Michela, Vella, Stefano   +15 more
core   +3 more sources

Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).

PLoS ONE, 2008
BackgroundThe dead-end (Dnd1) gene is essential for maintaining the viability of germ cells. Inactivation of Dnd1 results in sterility and testicular tumors. The Dnd1 encoded protein, DND1, is able to bind to the 3'-untranslated region (UTR) of messenger
Chitralekha Bhattacharya, Sita Aggarwal, Madhu Kumar, Amatul Ali, Angabin Matin   +4 more
doaj   +1 more source

部位特異的変異導入によるCBFβと相互作用するHIV-1 Vif残基の決定 [PDF]

, 2015
京都大学0048新制・課程博士博士(医学)甲第18881号医博第3992号新制||医||1009(附属図書館)31832京都大学大学院医学研究科医学専攻(主査)教授 小柳 義夫, 教授 松岡 雅雄, 教授 朝長 啓造学位規則第4条第1項該当Doctor of Medical ScienceKyoto ...
Matsui, Yusuke
core   +1 more source

Species-Specific Restriction of Apobec3-Mediated Hypermutation [PDF]

Journal of Virology, 2008
ABSTRACT Apobec proteins are a family of cellular cytidine deaminases, among which several members have been shown to have potent antiviral properties. This antiviral activity is associated with the ability to cause hypermutation of retroviral cDNA.
Edward P, Browne, Dan R, Littman
openaire   +2 more sources

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
A Gerrits, Albertina Ausema, Alice Gerrits, AR Whiteley, B Wang, Bert Dontje, Bruno M. Tesson, D Bryder, E Petretto, EC Forsberg, EE Schadt, EE Schadt, EJ Chesler, EJ Chesler, Ellen Weersing, G Dennis Jr, Gerald de Haan, Greg Gibson, HH Goring, J Wang, JD Storey, JJ Keurentjes, JL Peirce, JY Wu, KH Wang, L Bystrykh, Leonid V. Bystrykh, M Morley, MA West, MJ Anderson, MJ Kiel, MV Rockman, N Hubner, NB Ivanova, R Alberts, R Breitling, Rainer Breitling, RC Jansen, Ritsert C. Jansen, SA Monks, SM Chambers, V Emilsson, Xusheng Wang, Y Chen, Y Katoh, Y Li, Y Li, Y Liang, Yang Li   +48 more
core   +11 more sources