Heat increases the editing efficiency of human papillomavirus E2 gene by inducing upregulation of APOBEC3A and 3G [PDF]
, 2017 Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3 proteins have been identified as potent viral DNA mutators and have broad antiviral activity.
Chen, Hongduo +9 more
core +1 more source
A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif
Retrovirology, 2017 Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication.
Yusuke Nakano +7 more
doaj +1 more source
Footprint of the host restriction factors APOBEC3 on the genome of human viruses.
PLoS Pathogens, 2020 APOBEC3 enzymes are innate immune effectors that introduce mutations into viral genomes. These enzymes are cytidine deaminases which transform cytosine into uracil.
Florian Poulain +3 more
doaj +1 more source
Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs) [PDF]
, 2017 Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination of viral DNA and a not fully
Amorena, Beatriz +7 more
core +2 more sources
Mechanisms of APOBEC3 mutagenesis in human cancer cells
Nature, 2022 Abstract The APOBEC3 family of cytosine deaminases has been implicated in some of the most prevalent mutational signatures in cancer 1–3 . However, a causal link between endogenous APOBEC3 enzymes and mutational signatures in human cancer genomes has not been established ...
Mia Petljak +11 more
openaire +2 more sources
Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.
PLoS Pathogens, 2011 Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand ...
Diana S Smith +7 more
doaj +1 more source
Dolutegravir-based regimen maintains virological success in a patient with archived mutations to integrase inhibitors [PDF]
, 2017 no abstract ...
Falasca, Francesca +3 more
core +1 more source
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
Frontiers in Microbiology, 2014 The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to suppress replication of viruses with a single-stranded DNA intermediate by inducing mutagenesis and functional inactivation of the virus.
Yuqing eFeng +3 more
doaj +1 more source
Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]
, 2018 Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John +13 more
core +1 more source
APOBEC3-mediated restriction of RNA virus replication [PDF]
Scientific Reports, 2018 AbstractAPOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus. Although effects of APOBEC3 members on viral DNA have been demonstrated, it is not known whether they edit RNA ...
Aleksandra Milewska +7 more
openaire +5 more sources