Results 51 to 60 of about 7,631 (195)
Effect of Vif in doxorubicin treated breast cancer cells
Annals of Medicine, 2021 Introduction Several studies linked DNA cytosine deaminase APOBEC3 to mutational process driving carcinogenesis [1]. However, APOBEC3 expression varies in breast cancer cells [2] and their role in breast cancer treatment remains elusive.
Susana Bandarra +4 more
doaj +1 more source
APOBEC3 genes: retroviral restriction factors to cancer drivers [PDF]
Trends in Molecular Medicine, 2015 The APOBEC3 cytosine deaminases play key roles in innate immunity through their ability to mutagenize viral DNA and restrict viral replication. Recent advances in cancer genomics, together with biochemical characterization of the APOBEC3 enzymes, have now implicated at least two family members in somatic mutagenesis during tumor development.
Henderson, S, Fenton, TR
openaire +4 more sources
Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?
Viruses, 2018 The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified.
Zeli Zhang +6 more
doaj +1 more source
The APOBEC3 Family of Retroelement Restriction Factors [PDF]
, 2013 The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids.
Eric W, Refsland, Reuben S, Harris
openaire +2 more sources
Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles
Nature Communications, 2023 Antiretroviral APOBEC3 may contribute to HIV-1 latency. In this study, Ajoge and Renner et al. identify a previously undescribed function of human APOBEC3 proteins in redirecting integrations of HIV-1 DNA into more transcriptionally inactive regions of ...
Hannah O. Ajoge +10 more
doaj +1 more source
Structural Insights into APOBEC3-Mediated Lentiviral Restriction
Viruses, 2020 Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of intrinsic restriction factors is the APOBEC3 (A3) family of cytidine deaminases.
Krista A. Delviks-Frankenberry +2 more
openaire +3 more sources
Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance
Heliyon, 2019 The APOBEC3 enzymes can induce mutagenesis of HIV-1 proviral DNA through the deamination of cytosine. HIV-1 overcomes this restriction through the viral protein Vif that induces APOBEC3 proteasomal degradation.
Nazanin Mohammadzadeh +5 more
doaj +1 more source
APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model. [PDF]
PLoS Pathogens, 2014 Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral ...
Kei Sato +13 more
doaj +1 more source
Codon pairs of the HIV-1 vif gene correlate with CD4+T cell count [PDF]
, 2013 Background: the human APOBEC3G (A3G) protein activity is associated with innate immunity against HIV-1 by inducing high rates of guanosines to adenosines (G-to-A) mutations (viz., hypermutation) in the viral DNA. If hypermutation is not enough to disrupt
Bizinoto, Maria Clara +8 more
core +2 more sources
Heliyon, 2022 Background: Kidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of renal cell cancer. APOBEC3 activity has been identified in a variety of human cancers.
Ting Peng +9 more
doaj +1 more source