Results 61 to 70 of about 7,631 (195)

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins [PDF]

Journal of Virology, 2009
Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins Rebecca S. LaRue, Valgerdur Andresdottir, Yannick Blanchard, Silvestro G. Conticello, David Derse, Michael Emerman, Warner C. Greene, Stefan R. Jonsson, Nathaniel R. Landau, Martin Lochelt, Harmit S. Malik, Michael H. Malim, Carsten Munk, Stephen J. O’Brien, Vinay K.
Larue, Rebecca S., Andrésdóttir, Valgerdur, Blanchard, Yannick, Conticello, Silvestro G., Derse, David, Emerman, Michael, Greene, Warner C., Jónsson, Stefán R., Landau, Nathaniel R., Löchelt, Martin, Malik, Harmit S., Malim, Michael H., Münk, Carsten, O'Brien, Stephen J., Pathak, Vinay K., Strebel, Klaus, Wain-Hobson, Simon, Yu, Xiao-Fang, Yuhki, Naoya, Harris, Reuben S.   +19 more
openaire   +3 more sources

Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys

Retrovirology, 2011
Background The cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) are innate cellular factors that inhibit replication of a number of viruses, including HIV-1. Since antiviral activity of APOBEC3 has been mainly confirmed by in vitro data, we examined
Stahl-Hennig Christiane, Motzkus Dirk, Sauermann Ulrike, Mußil Bianka, Sopper Sieghart   +4 more
doaj   +1 more source

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [PDF]

, 2017
Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Bieniasz, Paul D., Blanco-Melo, Daniel, Gifford, Robert J.   +2 more
core   +2 more sources

APOBEC3 proteins and genomic stability [PDF]

Cell Cycle, 2012
The human APOBEC3 family of cytidine deaminases constitutes a cellular intrinsic defense mechanism that is effective against a range of viruses and retro-elements. While it is well established that these enzymes are powerful mutators of viral DNA, the possibility that their activity could threaten the integrity of the host genome has only recently ...
Iñigo, Narvaiza, Sébastien, Landry, Matthew D, Weitzman   +2 more
openaire   +2 more sources

Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements

Retrovirology, 2008
Background APOBEC3 cytosine deaminases have been demonstrated to restrict infectivity of a series of retroviruses, with different efficiencies depending on the retrovirus.
Heidmann Odile, Ribet David, Priet Stéphane, Esnault Cécile, Heidmann Thierry   +4 more
doaj   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Viral infection, APOBEC3 dysregulation, and cancer

Frontiers in Genetics
Viral infection plays a significant role in the development and progression of many cancers. Certain viruses, such as Human Papillomavirus (HPV), Epstein-Barr Virus (EBV), and Hepatitis B and C viruses (HBV, HCV), are well-known for their oncogenic potential.
Jake Lehle, Mohadeseh Soleimanpour, Samira Mokhtari, Diako Ebrahimi, Diako Ebrahimi, Diako Ebrahimi   +5 more
openaire   +3 more sources

Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A

Beilstein Journal of Organic Chemistry
Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the quick ...
Maksim V. Kvach, Stefan Harjes, Harikrishnan M. Kurup, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev   +5 more
doaj   +1 more source

Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

PLoS Pathogens, 2014
Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition.
Eun-Young Kim, Ramon Lorenzo-Redondo, Susan J Little, Yoon-Seok Chung, Prabhjeet K Phalora, Irina Maljkovic Berry, John Archer, Sudhir Penugonda, Will Fischer, Douglas D Richman, Tanmoy Bhattacharya, Michael H Malim, Steven M Wolinsky   +12 more
doaj   +1 more source

Urothelial Carcinoma of the Bladder Following BK Virus Infection in a Pediatric Kidney Transplant Recipient

Pediatric Transplantation, Volume 30, Issue 3, March 2026.
ABSTRACT Background Urothelial bladder carcinoma is extremely rare in children and its association with BK virus infection remains unclear. Methods We describe the case of an 11‐year‐old girl who developed a urothelial carcinoma of the bladder four years after receiving her first kidney transplant.
Martina Ichas, Lise Allard, Luke Harper, Mokrane Yacoub, Iona Madden, Cécile Vérité, Astrid Godron‐Dubrasquet, Jérôme Harambat   +7 more
wiley   +1 more source