Results 11 to 20 of about 3,562 (156)

Urinary virome perturbations in kidney transplantation [PDF]

, 2018
The human microbiome is important for health and plays a role in essential metabolic functions and protection from certain pathogens. Conversely, dysbiosis of the microbiome is seen in the context of various diseases. Recent studies have highlighted that
Carrie D. Nicora, Kristin Burnum-Johnson, Minnie M. Sarwal, Neil Mercer, Sharvin Nandoe, Sharvin Nandoe, Tara K. Sigdel, Wei-Jun Qian   +7 more
core   +19 more sources

Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]

Small Sci
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc   +2 more sources

Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. [PDF]

, 2015
Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions.
Chang, Li-Wen, DeRisi, Joseph L, Drazenovich, Tracy, Dunker, Freeland, Fisher, Debbie, Guzman, David S-M, Hawkins, Michelle G, Jacobson, Elliott R, Kamaka, Elizabeth K, Levens, Gregory, Meola, Linda F, Reavill, Drury R, Sanders, Chris, Stenglein, Mark D   +13 more
core   +6 more sources

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining. [PDF]

Adv Sci (Weinh)
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Wang H, Meng Y, Chen X, Cui X, Zuo Q, Han N, Liang X, Shen X, Li C, Li D, Wang F, He L, Chen R, Lu X, You W, Wu A, Chen RA, Chen W, Ding C, Shen Y.   +19 more
europepmc   +2 more sources

Prevalence of inclusion body disease and associated comorbidity in captive collections of boid and pythonid snakes in Belgium [PDF]

, 2020
Inclusion body disease (IBD) is caused by reptarenaviruses and constitutes one of the most notorious viral diseases in snakes. Although central nervous system disease and various other clinical signs have been attributed to IBD in boid and pythonid ...
Hellebuyck, Tom, Leineweber, Christoph, Marschang, Rachel E, Simard, Jules   +3 more
core   +1 more source

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities

Health Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem, Shafaq Zahid, Muhammad Hassan Hafeez, Arifa Bibi, Shehroze Tabassum, Aymar Akilimali   +5 more
wiley   +1 more source

Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)

Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023
Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo, Zhengrun Li, Shike Dong, Xiaoyan Si, Na Ta, Hanwei Liang, Lei Xu   +6 more
wiley   +1 more source

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Viruses, 2020
Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health.
Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre   +6 more
doaj   +1 more source

Lassa fever vaccine candidates: A scoping review of vaccine clinical trials

Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023
Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis, Alexandra Peebles, Nicole E. Basta   +2 more
wiley   +1 more source