Molecular characterization of arenavirus defective viral genomes reveals sequence features associated with their formation [PDF]
Journal of VirologyDefective viral genomes (DVGs) are byproducts of replication that arise during infection with diverse RNA viruses and can impact virus infection and disease outcome.
Thomas Hoenen +5 more
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Interaction of silver nanoparticles with Tacaribe virus [PDF]
Journal of Nanobiotechnology, 2010 Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is promising in light
Speshock Janice L +4 more
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Characterization of non-standard viral genomes during arenavirus infections identifies prominent S RNA intergenic region deletions [PDF]
mBioArenaviruses, a family of negative-sense RNA viruses spread by rodents, are a leading cause of severe hemorrhagic fever in humans. Due to a paucity of antivirals and vaccines for arenaviruses, there is a need to identify new mechanisms for interfering ...
Matthew Hackbart, Carolina B. López
doaj +2 more sources
Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties [PDF]
Cell Reports MedicineSummary: The non-cytopathic arenavirus lymphocytic choriomeningitis virus (LCMV) induces strong anti-tumor responses. To generate an optimized arenavirus for tumor therapy, we passage LCMV in human or murine tumor cells.
Philipp A. Lang +21 more
doaj +2 more sources
Novel Oliveros-like Clade C Mammarenaviruses from Rodents in Argentina, 1990–2020 [PDF]
VirusesFollowing an Argentine Hemorrhagic Fever (AHF) outbreak in the early 1990s, a rodent survey for Junín virus, a New World Clade B arenavirus, in endemic areas of Argentina was conducted.
Elizabeth Shedroff +12 more
doaj +2 more sources
Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates [PDF]
VaccinesArenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the immunogenicity of replicating (artPICV and artLCMV) and non-replicating (rPICV and rLCMV ...
Bhawna Sharma +19 more
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Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex [PDF]
mBioThe spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell ...
Guido C. Paesen +5 more
doaj +2 more sources
Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison
Viruses, 2022 Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant +3 more
doaj +1 more source
Viruses, 2022 Arenaviruses include important zoonotic pathogens that cause hemorrhagic fever (e.g., Junín virus; JUNV) as well as other viruses that are closely related but apathogenic (e.g., Tacaribe virus; TCRV).
Julia Holzerland +2 more
doaj +1 more source
Highly Diverse Arenaviruses in Neotropical Bats, Brazil
Emerging Infectious Diseases, 2022 We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes +14 more
doaj +1 more source