Results 41 to 50 of about 8,136 (194)
Arenavirus Concentration by Molecular Filtration [PDF]
Applied and Environmental Microbiology, 1977 Liter volumes of a human arenavirus pathogen (Machupo) and a nonpathogen (Tacaribe) were concentrated 30 to 100 times in less than 90 min without significant loss of particle infectivity.
J D, Gangemi +3 more
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Annual Review of Virology, 2017 Hemorrhagic fevers caused by viruses were identified in the late 1950s in South America. These viruses have existed in their hosts, the New World rodents, for millions of years. Their emergence as infectious agents in humans coincided with changes in the environment and farming practices that caused explosions in their host rodent populations ...
Nicolás, Sarute, Susan R, Ross
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Endangered wild salmon infected by newly discovered viruses
eLife, 2019 The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known
Gideon J Mordecai +11 more
doaj +1 more source
Arenavirus Phylogeny: A New Insight
Virus Genes, 1998 Arenaviridae is a worldwide distributed family, of enveloped, single stranded, RNA viruses. The arenaviruses were divided in two major groups (Old World and New World), based on serological properties and genetic data, as well as the geographic distribution. In this study the phylogenetic relationship among the members of the Arenaviridae was examined,
Albariño, César G. +4 more
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DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.
PLoS Pathogens, 2018 Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed ...
María Eugenia Loureiro +15 more
doaj +1 more source
Pathogenesis of arenavirus hemorrhagic fevers [PDF]
Expert Review of Anti-infective Therapy, 2011 Viral hemorrhagic fevers (VHFs) caused by arenaviruses belong to the most devastating emerging human diseases and represent serious public health problems. Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages associated with a shock syndrome in the terminal stage. Over the past years,
Marie-Laurence, Moraz, Stefan, Kunz
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Mopeia Virus–related Arenavirus in Natal Multimammate Mice, Morogoro, Tanzania
Emerging Infectious Diseases, 2009 A serosurvey involving 2,520 small mammals from Tanzania identified a hot spot of arenavirus circulation in Morogoro. Molecular screening detected a new arenavirus in Natal multimammate mice (Mastomys natalensis), Morogoro virus, related to Mopeia virus.
Stephan Günther +12 more
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The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.
PLoS Pathogens, 2021 Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). The mechanisms of GPC-mediated membrane fusion and of virus targeting to late endosomes are not well ...
Ruben M Markosyan +4 more
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Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform
Viruses, 2021 Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild ...
Stephen R. Welch +9 more
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Frontiers in Microbiology, 2019 The majority of emerging and reemerging zoonotic viral pathogens are RNA viruses. Pathogen discovery programs of emerging infectious diseases (EIDs) in wildlife have implicated rodents and shrews as hosts of diverse human pathogens, such as hantaviruses,
Samson Omondi Onyuok +24 more
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