Results 51 to 60 of about 8,136 (194)

Entry inhibitors as arenavirus antivirals. [PDF]

Front Microbiol
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options, the search for effective antivirals is imperative.
Iyer K, Yan Z, Ross SR.
europepmc   +4 more sources

Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia

Virulence, 2023
Mammarenaviruses, a genus of the family Arenaviridae, are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is ...
Brigitte Flannery, Michaela Cain, Hinh Ly   +2 more
doaj   +1 more source

Analyzing Machupo virus-receptor binding by molecular dynamics simulations [PDF]

, 2014
In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Ellington, Andrew D., Meyer, Austin G., Sawyer, Sara L., Wilke, Claus O.   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Envelope Glycoprotein of Arenaviruses

Viruses, 2012
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for ...
Antonella Pasquato, Stefan Kunz, Dominique J. Burri, Joel Ramos da Palma   +3 more
doaj   +1 more source

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]

PLoS Pathogens, 2009
Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin   +11 more
doaj   +1 more source

Viral RNA and infectious virus in mucosal specimens from guinea pigs modelling early phases of lethal and non-lethal Lassa fever

Emerging Microbes and Infections, 2022
Lassa fever (LF) is endemic to broad regions of West Africa. Infection with Lassa virus (LASV), the etiologic agent of LF, results in a spectrum of clinical signs in humans, including severe and lethal hemorrhagic disease.
Stephen R. Welch, Sarah C. Genzer, JoAnn D. Coleman-McCray, Jessica R. Harmon, Florine E.M. Scholte, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler   +7 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source