Results 31 to 40 of about 181,531 (180)

Functional profiling of 2,193 ASS1 missense variants: Insights into variant pathogenicity and epistatic interactions in citrullinemia type I. [PDF]

PLoS Genetics
Sequence variants in the urea cycle gene argininosuccinate synthase (ASS1) cause Citrullinemia type 1 (CTLN1), a rare autosomal recessive disease. Mechanistically, reduction in argininosuccinate synthetase (ASS) enzyme activity impairs the urea cycle ...
Russell S Lo, Gareth A Cromie, Michelle Tang, Amy Sirr, Ljubica Caldovic, Hiroki Morizono, Nicholas Ah Mew, Andrea Gropman, Aimée M Dudley   +8 more
doaj   +2 more sources

Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway

Frontiers in Pharmacology, 2021
Background: Pulmonary Fibrosis (PF) is an interstitial lung disease characterized by excessive accumulation of extracellular matrix in the lungs, which disrupts the structure and gas exchange of the alveoli.
Lili Zhang, Sihao Qu, Lu Wang, Chunguo Wang, Qinghe Yu, Zhimin Zhang, Yirui Diao, Binbin Zhang, Yadong Li, Yuanyuan Shi, Yuanyuan Shi, Peng Wang   +11 more
doaj   +1 more source

l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung

Frontiers in Immunology, 2017
Activation, recruitment, and effector function of T lymphocytes are essential for control of mycobacterial infection. These processes are tightly regulated in T cells by the availability of l-arginine within the microenvironment.
Shannon M. Lange, Shannon M. Lange, Melanie C. McKell, Melanie C. McKell, Stephanie M. Schmidt, Austin P. Hossfeld, Vandana Chaturvedi, Jeremy M. Kinder, Jaclyn W. McAlees, Ian P. Lewkowich, Sing Sing Way, Joanne Turner, Joanne Turner, Joseph E. Qualls   +13 more
doaj   +1 more source

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. [PDF]

PLoS ONE, 2014
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown.
Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka   +6 more
doaj   +1 more source

L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia

Respiratory Research, 2012
Background Hyperoxia is shown to impair airway relaxation via limiting L-arginine bioavailability to nitric oxide synthase (NOS) and reducing NO production as a consequence. L-arginine can also be synthesized by L-citrulline recycling.
Sopi Ramadan B, Zaidi Syed IA, Mladenov Mitko, Sahiti Hazbije, Istrefi Zahide, Gjorgoski Icko, Lajçi Azem, Jakupaj Muharrem   +7 more
doaj   +1 more source

Structure of human argininosuccinate synthetase

, 2008
Argininosuccinate synthetase catalyzes the transformation of citrulline and aspartate into argininosuccinate and pyrophos­phate using the hydrolysis of ATP to AMP and pyrophos­phate.
Karlberg, T., van den Berg, S., Flores, A., Hammarstrom, M., Collins, R., Uppenberg, J., Holmberg Schiavone, L., Hogbom, M., Karlberg, T,, Flores, A, Schiavone, LH, Collins, R,, Hammarstrom, M, Hogbom, M, van, den Berg S,, Uppenberg, J   +15 more
core   +2 more sources

The central metabolism of M. alcaliphilum 20Z.

, 2023
1 –hexulose 6-phosphate synthase, 2 –phosphohexuloisomerase 3 –PPi-dependent 6-phosphofructokinase, 4 –glyceraldehyde-3-phosphate dehydrogenase, 5 –pyruvate dehydrogenase complex, 6 –citrate synthase, 7 –aconitase, 8 –isocitrate dehydrogenase, 9 – α ...
Valentina N. Khmelenina (7878662), Ildar I. Mustakhimov (7878653), Alexander S. Reshetnikov (17290975), Maxim V. Molchanov (17290978), Oleg I. Melnikov (17290972), Andrey V. Machulin (7300226), Olga N. Rozova (7878650)   +6 more
core   +1 more source

Dietary N-carbamylglutamate supplementation improves ammonia tolerance of juvenile yellow catfish Pelteobagrus fulvidraco

Frontiers in Physiology, 2023
Introduction: Ammonia has been of concern for its high toxicity to animals. N-carbamylglutamate (NCG) can reduce blood ammonia levels in mammals, but studies on ammonia tolerance in fish are insufficient.Methods: Juvenile yellow catfish were fed two ...
Dexiang Feng, Zhiguo Yang, Ming Li
doaj   +1 more source

The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis

RNA Biology, 2023
The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Haiyang Wang, Bin Tang, Guoping Zhu, Xiangting Wang   +4 more
doaj   +1 more source

An assay for argininosuccinate synthetase in Neurospora [PDF]

, 1965
An assay for argininosuccinate synthetase in ...
Fairley, J. L., J. L. Fairley, Wampler, D. E., D. E. Wampler   +3 more
core   +1 more source