Results 21 to 30 of about 181,531 (180)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Background Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to liver cancer because it was detected at an advanced stages in patients with liver dysfunction, making HCC ...
Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo   +9 more
doaj   +2 more sources

Reciprocal Changes of Renal Neuronal Nitric Oxide Synthase-α and -β Associated With Renal Progression in a Neonatal 5/6 Nephrectomized Rat Model

Pediatrics and Neonatology, 2011
Nitric oxide (NO) deficiency contributes to chronic kidney disease progression. NO deficiency could occur for many reasons, one of which is decreased NO synthase (NOS) abundance and/or activity.
You-Lin Tain, Sid Ghosh, Richard J. Krieg, Chris Baylis   +3 more
doaj   +2 more sources

Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function [PDF]

Biochemical and Biophysical Research Communications, 2012
Diminished vascular endothelial cell nitric oxide (NO) production is a major factor in the complex pathogenesis of diabetes mellitus. In this report, we demonstrate that insulin not only maintains endothelial NO production through regulation of endothelial nitric oxide synthase (eNOS), but also via the regulation of argininosuccinate synthase (AS ...
Ricci J, Haines, Karen D, Corbin, Laura C, Pendleton, Cynthia J, Meininger, Duane C, Eichler   +4 more
openaire   +3 more sources

Dual Urea Cycle Dysfunction Caused by Coexisting Argininosuccinic Aciduria and Citrin Deficiency: Clinical, Biochemical, and Molecular Insights From an Exceptional Case [PDF]

JIMD Reports, Volume 67, Issue 6, November 2026.
ABSTRACT Dual inherited defects affecting urea cycle function are exceptionally rare. We report the first case, to our knowledge, of the coexistence of argininosuccinic aciduria (ASA) and citrin deficiency (CD). A girl born to consanguineous Tunisian parents presented at 6 months of age with recurrent seizures, vomiting, developmental delay, and severe
Mouna Zribi, Mariem Bhouri, Safa Khatrouch, Hela Boudabous, Johannes Häberle, Mohamed Slim Abdelmoula, Amel Ben Chehida   +6 more
wiley   +2 more sources

Etoposide-induced protein 2.4 homolog promotes argininosuccinate synthase 1 and cancer cell survival upon arginine deprivation [PDF]

Cellular & Molecular Biology Letters
Background Arginine auxotrophy has been reported in a subset of cancers with inherently defective de novo arginine synthesis. However, the use of arginine deprivation therapy seems to be unequally effective, partially owing to the resistance acquired by ...
Vu T. A. Vo, Le Nhat Tran, Thu Thanh Bui, Han-Woong Lee, Yangsik Jeong   +4 more
doaj   +2 more sources

Inadvertent gene silencing of argininosuccinate synthase ( bcass1 ) in Botrytis cinerea by the pLOB1 vector system [PDF]

Molecular Plant Pathology, 2010
SUMMARY For several years, researchers working on the plant pathogen Botrytis cinerea and a number of other related fungi have routinely used the pLOB1 vector system, based on hygromycin resistance, under the control of the Aspergillus nidulans oliC
Patel, R.M., van Kan, J.A.L., Bailey, A.M., Foster, G.D.   +3 more
openaire   +5 more sources

Argininosuccinate synthase: at the center of arginine metabolism. [PDF]

International journal of biochemistry and molecular biology, 2011
The levels of L-arginine, a cationic, semi-essential amino acid, are often controlled within a cell at the level of local availability through biosynthesis. The importance of this temporal and spatial control of cellular L-arginine is highlighted by the tissue specific roles of argininosuccinate synthase (argininosuccinate synthetase) (EC 6.3.4.5), as ...
Ricci J, Haines, Laura C, Pendleton, Duane C, Eichler   +2 more
openaire   +2 more sources

NITRIC OXIDE (NO), CITRULLINE - NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN

International Journal of Medical Sciences, 2010
Nitric oxide is postulated to be involved in the pathophysiology of neurological disorders due to hypoxia/ anoxia in brain due to increased release of glutamate and activation of N-methyl-D-aspartate receptors.
M. Swamy, Mohd Jamsani Mat Salleh, K. N .S. Sirajudeen, Wan Roslina Wan Yusof, G. Chandran
doaj   +1 more source

Role of Argininosuccinate Synthase 1 ‐Dependent L‐Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis [PDF]

Advanced Science
Atherosclerosis is initiated with endothelial cell (EC) dysfunction and vascular inflammation under hyperlipidemia. Sirtuin 3 (SIRT3) is a mitochondrial deacetylase.
Xiaoyun Cao, Vivian Wei Yan Wu, Yumeng Han, Huiling Hong, Yalan Wu, Alice Pik Shan Kong, Kathy O Lui, Xiao Yu Tian   +7 more
doaj   +2 more sources

Retraction: Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management. [PDF]

PLoS Neglected Tropical Diseases, 2023
PLOS Neglected Tropical Diseases Editors
doaj   +2 more sources