Results 1 to 10 of about 133 (87)

A Pan-Cancer Analysis of the Role of Argininosuccinate Synthase 1 in Human Tumors

Frontiers in Oncology, 2023
AimThere is accumulating evidence indicating that ASS1 is closely related to tumors. No pan-cancer analysis of ASS1 was available.MethodsHere we explored the gene expression and survival analysis of ASS1 across thirty-three tumors based on the datasets ...
Qiang Ding, Qiang Ding, Qiang Ding, Ruiqi Li, Ruiqi Li, Ruiqi Li, Qingming Wang, Qingming Wang, Qingming Wang, Li Yu, Li Yu, Li Yu, Fuming Zi, Fuming Zi, Fuming Zi   +14 more
exaly   +3 more sources

Heterologous Expression of Argininosuccinate Synthase From Oenococcus oeni Enhances the Acid Resistance of Lactobacillus plantarum

Frontiers in Microbiology, 2019
Oenococcus oeni can survive well in wine (an acid-stress environment) and dominate malolactic fermentation (MLF). To demonstrate a possible role of argininosuccinate synthase gene (argG) in the acid tolerance response of O.
Longxiang Liu, Lin Yuan, Hua Wang
exaly   +3 more sources

Indexes of citrulline metabolism in rat liver under the toxic injury against the background of alimentary protein deficiency [PDF]

The Ukrainian Biochemical Journal, 2020
It is known that citrulline is converted into arginine in the series of metabolic transformations. Results of our previous studies showed that acetaminophen-induced toxic injury on the background of the alimentary deprivation of protein is accompanied by
H. P. Kopylchuk, I. M. Nykolaichuk, I. S. Lylyk   +2 more
doaj   +1 more source

Argininosuccinate synthase 1, arginine deprivation therapy and cancer management

Frontiers in Pharmacology, 2022
Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in the nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide sufficient energy and build biomass to sustain their transformed state and ...
Naihui Sun, Xing Zhao
doaj   +1 more source

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Nature Communications, 2021
Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is
Zizheng Zou, Xiyuan Hu, Tiao Luo, Zhengnan Ming, Xiaodan Chen, Li Xia, Wensong Luo, Jijia Li, Na Xu, Ling Chen, Dongsheng Cao, Min Wen, Fanrong Kong, Kunjian Peng, Yuanzhu Xie, Xuan Li, Dayou Ma, Chuanyu Yang, Ceshi Chen, Wenjun Yi, Ousheng Liu, Suyou Liu, Junli Luo, Zhiyong Luo   +23 more
doaj   +1 more source

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

Cancer & Metabolism, 2021
Background Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes.
Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith, M. Celeste Simon   +7 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience

Journal of Pediatric Research, 2023
Aim:Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes ...
Ayşe Ergül Bozacı, Emine Göksoy, Aysel Tekmenuray Ünal, Hatice Mutlu Albayrak, İbrahim Taş, Berat Kanar, Mehmet Nuri Özbek, Melis Köse   +7 more
doaj   +1 more source

The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

Cancer & Metabolism, 2021
Background Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response.
Alexandra Giatromanolaki, Adrian L. Harris, Michael I. Koukourakis   +2 more
doaj   +1 more source

In Search of Antioxidant Peptides from Porcine Liver Hydrolysates Using Analytical and Peptidomic Approach

Antioxidants, 2021
The search for antioxidant peptides as health-promoting agents is of great scientific interest for their biotechnological applications. Thus, the main goal of this study was to identify antioxidant peptides from pork liver using alcalase, bromelain ...
María López-Pedrouso, José M. Lorenzo, Paula Borrajo, Daniel Franco   +3 more
doaj   +1 more source