Results 11 to 20 of about 181,531 (180)

Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Gene expression analysis in Leishmania donovani (Ld) identified an orthologue of the urea cycle enzyme, argininosuccinate synthase (LdASS), that was more abundantly expressed in amastigotes than in promastigotes.
Ines Lakhal-Naouar, Armando Jardim, Rona Strasser, Shen Luo, Yukiko Kozakai, Hira L Nakhasi, Robert C Duncan   +6 more
doaj   +6 more sources

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.

PLoS Neglected Tropical Diseases, 2016
Reactive oxygen and nitrogen species (ROS and RNS) produced by the phagocytic cells are the most common arsenals used to kill the intracellular pathogens.
Abul Hasan Sardar, Armando Jardim, Ayan Kumar Ghosh, Abhishek Mandal, Sushmita Das, Savita Saini, Kumar Abhishek, Ruby Singh, Sudha Verma, Ajay Kumar, Pradeep Das   +10 more
doaj   +5 more sources

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency [PDF]

Stem Cell Research & Therapy, 2017
Background Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal recessive disorder characterized ...
Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta, Giovanni Camussi   +13 more
doaj   +7 more sources

Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis [PDF]

Molecular Therapy, 2021
Argininosuccinate synthase 1 (ASS1) serves as a critical enzyme in arginine biosynthesis; however, its role in interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF), remains largely unknown. This study aims at characterization and targeting of ASS1 deficiency in pulmonary fibrosis.
Li, Ji-Min, Yang, David C, Oldham, Justin, Linderholm, Angela, Zhang, Jun, Liu, Jun, Kenyon, Nicholas J, Chen, Ching-Hsien   +7 more
core   +6 more sources

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 [PDF]

Cell Reports, 2016
Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expression is lost in a range of tumor types, including 50% of malignant pleural mesotheliomas.
Matthew Locke, Essam Ghazaly, Marta O. Freitas, Mikaella Mitsinga, Laura Lattanzio, Cristiana Lo Nigro, Ai Nagano, Jun Wang, Claude Chelala, Peter Szlosarek, Sarah A. Martin   +10 more
doaj   +5 more sources

Argininosuccinate synthase 1 (ASS1) orchestrates arginine metabolism and ornithine production to modulate CHIKV infection [PDF]

Journal of Virology
Viruses reprogram the host metabolic machinery to ensure a continuous supply of macromolecules and energy for their own survival. Important cellular pathways are impacted during infection, resulting in changes in key metabolic precursors that influence ...
Nimisha Mishra, Mothe Sravya, Sonali Hanjankar, Anjali Singh, Yash Chaudhary, Ranjan Kumar Nanda, Sujatha Sunil   +6 more
doaj   +5 more sources

Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice [PDF]

Hepatology, 2012
AbstractArgininosuccinate synthase (ASS) is the rate-limiting enzyme in both the urea and the l-citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels, and NO· generation. Because a proteomics analysis identified ASS and nitric oxide synthase-2 (NOS2) as coinduced in rat hepatocytes by chronic ethanol consumption, which also
Tung Ming, Leung, Yongke, Lu, Wei, Yan, Jose A, Morón-Concepción, Stephen C, Ward, Xiaodong, Ge, Laura, Conde de la Rosa, Natalia, Nieto   +7 more
core   +4 more sources

Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53 [PDF]

Science Advances, 2017
ASS1 bridges a gap between p53 and Akt.
Takafumi Miyamoto, Paulisally Hau Yi Lo, Naomi Saichi, Koji Ueda, Makoto Hirata, Chizu Tanikawa, Koichi Matsuda   +6 more
openaire   +3 more sources

Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity

ACS Chemical Biology, 2017
Like many cancer types, colorectal cancers have dysregulated metabolism that promotes their pathogenic features. In this study, we used the activity-based protein profiling chemoproteomic platform to profile cysteine-reactive metabolic enzymes that are upregulated in primary human colorectal tumors.
Leslie A. Bateman, Wan-Min Ku, Martin J. Heslin, Carlo M. Contreras, Christine F. Skibola, Daniel K. Nomura   +5 more
core   +4 more sources

Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development

Human Cell, 2023
Argininosuccinate synthase (ASS1) is involved in nitric oxide production, which has a key role in placental development improving pregnancy outcomes. Syncytiotrophoblast and extravillous trophoblast differentiations are milestones of placental development and their impairment can cause pathologies, such as preeclampsia (PE) and fetal growth restriction
Fantone, Sonia, Ermini, Leonardo, Piani, Federica, Di Simone, Nicoletta, Barbaro, Greta, Giannubilo, Stefano Raffaele, Gesuita, Rosaria, Tossetta, Giovanni, Marzioni, Daniela   +8 more
core   +7 more sources