Results 81 to 90 of about 181,531 (180)
Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene [PDF]
, 2014 Argininosuccinate lyase deficiency (ASLD) is caused by a defect of the urea cycle enzyme argininosuccinate lyase (ASL) encoded by the ASL gene. Patients often present early after birth with hyperammonemia but can also manifest outside the neonatal period
Rüfenacht, Véronique +14 more
core +1 more source
MedComm, Volume 7, Issue 11, November 2026.This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production
Microbial Biotechnology, Volume 19, Issue 11, November 2026.This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri +2 more
wiley +1 more source
, 2010 The present invention is based in part on the discovery that the upstream open reading frame (uORF) in the extended 5′-untranslated region (5′-UTR) argininosuccinate synthase (AS) mRNA species is functional, and when functional, limits overall AS ...
Pendleton, Laura C. +2 more
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Advanced Science, Volume 13, Issue 58, 19 October 2026.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
The Role and Regulation of Argininosuccinate Synthase in Endothelial Function
, 2005 While cellular levels of arginine greatly exceed the apparent Km for endothelial nitric oxide synthase (eNOS), nitric oxide (NO) production is limited by availability of arginine. Results from this work have provided a unique understanding of endothelial
Goodwin, Bonnie L
core
The effects of quercetin on the gene expression of arginine metabolism key enzymes in human embryonic kidney 293 cells [PDF]
, 2021 Background: Arginine metabolism is an important factor involved in tumorigenesis, progression, and survival of tumor cells. Besides, other metabolites produced in the arginine metabolism process, such as polyamines, nitric oxide, argininosuccinate, and ...
Farivar, S. +5 more
core
Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy
MedComm, Volume 7, Issue 10, October 2026.Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu +6 more
wiley +1 more source
, 2014 Enzymes that are involved in these pathways are labeled with colors that indicate the fold change (log2) in their transcript levels in urea-grown cells relative to nitrate-grown cells (color code is provided in the figure).
Jing-Yi Cen (648108) +5 more
core +1 more source
Early cirrhosis in a patient with type I citrullinaemia (CTLN1)
, 2004 A 17-month-old girl with type I classical citrullinaemia (CTLN1) presenting with early cirrhosis and unusual ultrastructural features of the liver is reported.
E. Aşan +9 more
core +1 more source