Results 91 to 100 of about 181,531 (180)

Requirement of argininosuccinate lyase for systemic nitric oxide production [PDF]

, 2011
Nitric oxide (NO) is crucial in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (encoded by Asl) deficiency has a distinct phenotype of multiorgan dysfunction and NO deficiency.
Nagamani, Sandesh CS., Garg, Harsha K., Terry K Bertin, Bertin, Terry K., Ayelet Erez, William E O'Brien, William E Mitch, O’Brien, William E., Mian, Asad, Harrison, David G., Summar, Marshall, Marshall Summar, Harsha K Garg, Premkumar, Muralidhar H., Tang, Yaoping, Yuqing Chen, Juan C Marini, Brendan Lee, Muralidhar H Premkumar, Philippe M Campeau, Li Li, Zeng, Heng, Bryan, Nathan S., Li, Li, Mitch, William E., Yaoping Tang, Nathan S Bryan, Judy L Aschner, Chen, Yuqing, Erez, Ayelet, Shchelochkov, Oleg A., Sandesh C S Nagamani, Marini, Juan C., Campeau, Philippe M. Campeau, Reddy, Anilkumar K., Oleg A Shchelochkov, Anilkumar K Reddy, David G Harrison, Jennifer O Black, Black, Jennifer O., Lee, Brendan, Aschner, Judy L., Asad Mian, Heng Zeng   +43 more
core   +1 more source

The two major pathways metabolizing ammonia: the urea cycle (periportal), and glutamine synthesis (pericentral).

, 2014
In the urea cycle: ammonia and bicarbonate form carbamoylphosphate via carbamoyl phosphate synthetase1 (CPS1). This reaction requires N-acetylglutamate (acquired via a reaction catalysed by N-acetylglutamate synthase (NAGS)), Mg2+ and MgATP ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Absolute abundances of transcripts related to N assimilation pathway and the urea cycle.

, 2014
The transcript abundance that was obtained from RNA-seq data is indicated as RPKM (see Methods). The abundance of NasB transcript is shown on the right Y axis, while that of other transcripts is shown on the left Y axis.
Jing-Yi Cen (648108), Kai-Xuan Huang (648105), Yue-Lei Dong (648109), Hua-Long Wang (648106), Song-Hui Lu (648107), Hong-Po Dong (648104)   +5 more
core   +1 more source

Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension

Cell Reports, 2017
Fumarase catalyzes the interconversion of fumarate and L-malate in the tricarboxylic acid cycle. The Dahl salt-sensitive (SS) rat, a model of salt-sensitive hypertension, exhibits fumarase insufficiencies.
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang, Zhongmin Tian   +6 more
doaj   +1 more source

l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo

Journal of Pharmacological Sciences, 2015
l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production.
Asami Mori, Masahiko Morita, Koji Morishita, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii   +5 more
doaj   +1 more source

Detection of homozygous genotypes for a putatively lethal recessive mutation in the porcine argininosuccinate synthase 1 (ASS1) gene [PDF]

, 2019
The sequencing of the pig genome revealed the existence of homozygous individuals for a nonsense mutation in the argininosuccinate synthase 1 (ASS1) gene (rs81212146, c.944T>A, L315X).
Luigi‐Sierra, M.G., Luigi-Sierra, Maria Gracia, Luigi Sierra, Maria Gracia, Quintanilla, R., Mármol-Sánchez, Emilio, Amills, Marcel, R. Quintanilla, E. Mármol‐Sánchez, Mármol‐Sánchez, E., Amills, M., M.G. Luigi‐Sierra, Quintanilla, Raquel, Amills i Eras, Marcel, M. Amills   +13 more
core   +1 more source

Citrin-deficient patient-derived induced pluripotent stem cells as a pathological liver model for congenital urea cycle disorders

Molecular Genetics and Metabolism Reports
Citrin deficiency is a congenital secondary urea cycle disorder lacking useful disease models for effective treatment development. In this study, human induced pluripotent stem cells (iPSCs) were generated from two patients with citrin deficiency and ...
Mai Okano, Masahiro Yasuda, Yui Shimomura, Yoshikazu Matsuoka, Yasumasa Shirouzu, Tatsuya Fujioka, Masatoshi Kyo, Shoji Tsuji, Kazunari Kaneko, Hirofumi Hitomi   +9 more
doaj   +1 more source

Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma

Acta Biochimica et Biophysica Sinica, 2019
Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely correlated with poor prognosis in HCC ...
Xuemei, Tao, Qiaozhu, Zuo, Haoyu, Ruan, Hui, Wang, Haojie, Jin, Zhuoan, Cheng, Yuanyuan, Lv, Wenxin, Qin, Cun, Wang   +8 more
openaire   +2 more sources

Transcript levels of genes encoding either urea cycle enzymes or enzymes in linked pathways determined at 400 ppm and 100 ppm CO₂ and standardized to PP2A.

, 2019
Data are the mean of five biological replicates ± SD. Significance was tested according to the two-tailed Student's t-test (* p2 ratios to allow this test.
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis

BMC Microbiology
The availability of nutrients is closely linked to the protein expression profile of microorganisms. In this study, a comparative investigation has been performed to examine the expression patterns of cell associated proteins and secreted proteins in ...
Wanting Zhu, Yujing Wang, Yanxin Li, Changjiang Zang, Hongning Jiang, Qijing Du, Jun Wang, Rongbo Fan, Rongwei Han, Yongxin Yang   +9 more
doaj   +1 more source